Cox7a2 mediates steroidogenesis in TM3 mouse Ley dig cells

Asian Journal of Andrology

Volumn 8, Issue 5, 2006, Pages 589-594

  Chen, Liang ^a   Xin, Zhong Cheng ^a   Li, Xin ^b   Tian, Long ^a   Yuan, Yi Ming ^a   Liu, Gang ^a   Jiang, Xue Jun ^c   Guo, Ying Lu ^a  

^a PEKING UNIVERSITY FIRST HOSPITAL   (China)

^b People's Hospital of Zhangqiu   (China)

^c INSTITUTE OF MICROBIOLOGY   (China)

Author keywords

Cox7a2; Fusion protein; Leydig cell; Reactive oxygen species; Steroidogenesis; Steroidogenicacute regulatory protein

Indexed keywords

COMPLEMENTARY DNA; CYTOCHROME 7A2; CYTOCHROME C OXIDASE; HYBRID PROTEIN; LUTEINIZING HORMONE; REACTIVE OXYGEN METABOLITE; STEROIDOGENIC ACUTE REGULATORY PROTEIN; TESTOSTERONE; UNCLASSIFIED DRUG;

ANALYSIS OF VARIANCE; ANIMAL CELL; ARTICLE; CELL CULTURE; CELL LINE; CONTROLLED STUDY; DNA SEQUENCE; ENZYME LINKED IMMUNOSORBENT ASSAY; FLUOROMETRY; GENE EXPRESSION REGULATION; GENE OVEREXPRESSION; GENETIC TRANSFECTION; HORMONE INHIBITION; LEYDIG CELL; MALE; MOLECULAR CLONING; MOUSE; MOUSE STRAIN; NONHUMAN; PLASMID; PROTEIN ANALYSIS; PROTEIN EXPRESSION; PROTEIN FUNCTION; REGULATORY MECHANISM; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; STEROIDOGENESIS; STUDENT T TEST; TESTOSTERONE RELEASE; WESTERN BLOTTING;

ANIMALS; CELL LINE; CLONING, MOLECULAR; ELECTRON TRANSPORT COMPLEX IV; LEYDIG CELLS; LUTEINIZING HORMONE; MALE; MICE; PHOSPHOPROTEINS; PLASMIDS; REACTIVE OXYGEN SPECIES; RECOMBINANT PROTEINS; TESTOSTERONE; TRANSFECTION;

EID: 33747626532     PISSN: 1008682X     EISSN: 17457262     Source Type: Journal    
DOI: 10.1111/j.1745-7262.2006.00178.x     Document Type: Article

References (20)

1. Lunenfeld B. Aging men-challenges ahead. Asian J Androl 2001; 3: 161-8.
2. Morales A, Heaton JP, Carson, CC 3rd. Andropause: A misnomer for a true clinical entity. J Urol 2000; 163: 705-12.
3. Wang C, Leung A, Sinha-Hikim AP. Reproductive aging in the male Brown Norway rat: A model for the human. Endocrinology 1993; 133: 2773-81.
4. Walker DW, Benzer S. Mitochondrial "swirls" induced by oxygen stress and in the Drosophila mutant hyperswirl. Proc Natl Acad Sci USA 2004; 101: 10290-5.
5. Hoffmann S, Spitkovsky D, Radicella JP, Epe B, Wiesner RJ. Reactive oxygen species derived from the mitochondrial respiratory chain are not responsible for the basal levels of oxidative base modifications observed in nuclear DNA of Mammalian cells. Free Radic Biol Med 2004; 36: 765-73.
6. Zirkin BR, Chen H. Regulation of Leydig cell steroidogenic function during aging. Bio Reprod 2000; 63: 977-81.
7. Christenson LK, Strauss, JF 3rd. Steroidogenic acute regulatory protein (StAR) and the intramitochondrial translocation of cholesterol. Biochim Biophys Acta 2000; 1529: 175-87.
8. Stocco DM. Recent advances in the role of StAR. Rev Reprod 1998; 3: 82-5.
9. Stocco DM. StARTing to understand cholesterol transfer. Nat Struct Biol 2000; 7: 445-7.
10. Xin Z, Liu W, Tian L, Yuan Y, Xin H, Fu J, et al. Studies on the testis regression related gene profile in aged male. Beijing Da Xue Xue Bao 2003; 35: 364-8.
11. Chrzanowska-Lightowlers ZM, Turnbull DM, Bindoff LA, Lightowlers RN. An antisense oligodeoxynucleotide approach to investigate the function of the nuclear-encoded subunits of human cytochrome c oxidase. Biochem Biophys Res Commun 1993; 196: 328-35.
12. Musa FR, Takenaka I, Konishi R, Tokuda M. Effects of luteinizing hormone, follicle-stimulating hormone, and epidermal growth factor on expression and kinase activity of cyclin-dependent kinase 5 in Leydig TM3 and Sertoli TM4 cell lines. J Androl 2000; 21: 392-402.
13. Mather JP. Establishment and characterization of two distinct mouse testicular epithelial cell lines. Biol Reprod 1980; 23: 243-52.
14. Zheng Y, Zhou ZM, Min X, Li JM, Sha JH. Identification and characterization of the BGR-like gene with a potential role in human testicular development/spermatogenesis. Asian J Androl 2005; 7: 21-32.
15. Diemer T, Allen JA, Hales KH, Hales DB. Reactive oxygen disrupts mitochondria in MA-10 tumor Leydig cells and inhibits steroidogenic acute regulatory (StAR) protein and steroidogenesis. Endocrinology 2003; 144: 2882-91.
16. Margolin Y, Aten RF, Behrman HR. Antigonadotropic and antisteroidogenic actions of peroxide in rat granulosa cells. Endocrinology 1990; 127: 245-50.
17. Sultana T, Svechnikov KV, Gustafsson K, Wahlgren A, Tham E, Weber G, et al. Molecular identity, expression and functional analysis of interleukin-1 alpha and its isoforms in rat testis. Asian J Androl 2004; 6: 149-53.
18. Moundipa PF, Beboy NS, Zelefack F, Ngouela S, Tsamo E, Schill WB, et al. Effects of Basella alba and Hibiscus macranthus extracts on testosterone production of adult rat and bull Leydig cells. Asian J Androl 2005; 7: 411-7.
19. Hauet T, Yao ZX, Bose HS, Wall CT, Han Z, Li W, et al. Peripheral-type benzodiazepine receptor-mediated action of steroidogenic acute regulatory protein on cholesterol entry into leydig cell mitochondria. Mol Endocrinol 2005; 19: 540-54.
20. Hauet T, Liu J, Li H, Gazouli M, Culty M, Papadopoulos V. PBR, StAR, and PKA: Partners in cholesterol transport in steroidogenic cells. Endocr Res 2002; 28: 395-401.