Immune response in humans to a nasal boost with Streptococcus mutans antigens

Oral Microbiology and Immunology

Volumn 21, Issue 5, 2006, Pages 309-313

  Childers, N K ^a   Li, F ^a,d   Dasanayake, A P ^a,e   Li, Y ^a   Kirk, K ^b   Michalek, S M ^c  

^a UNIVERSITY OF ALABAMA AT BIRMINGHAM   (United States)

^b UNIVERSITY OF ALABAMA SCHOOL OF MEDICINE   (United States)

^c University of Alabama at Birmingham   (United States)

^d BOSTON UNIVERSITY   (United States)

^e NEW YORK UNIVERSITY   (United States)

Author keywords

Dental caries; Nasal immunization; Secretory immunoglobulin A; Streptococcus mutans

Indexed keywords

BACTERIAL ENZYME; BACTERIUM ANTIBODY; ENRICHED GLUCOSYLTRANSFERASE; GLUCOSYLTRANSFERASE; IMMUNOGLOBULIN A; STREPTOCOCCUS ANTIGEN; STREPTOCOCCUS MUTANS ANTIGEN; UNCLASSIFIED DRUG;

ABSENCE OF SIDE EFFECTS; ADULT; ARTICLE; CLINICAL TRIAL; CONTROLLED CLINICAL TRIAL; CONTROLLED STUDY; DOUBLE BLIND PROCEDURE; DRUG ADMINISTRATION ROUTE; HUMAN; HUMAN EXPERIMENT; IMMUNE RESPONSE; IMMUNIZATION; IMMUNOGLOBULIN BLOOD LEVEL; INTRATONSILLAR DRUG ADMINISTRATION; NORMAL HUMAN; NOSE CAVITY; RANDOMIZED CONTROLLED TRIAL; REVACCINATION; SALIVA; SECONDARY IMMUNE RESPONSE; SERUM; STREPTOCOCCUS MUTANS; TONSIL;

ADMINISTRATION, INTRANASAL; ADMINISTRATION, ORAL; ADULT; ANTIBODIES, BACTERIAL; ANTIGENS, BACTERIAL; DENTAL CARIES; GLYCOSYLTRANSFERASES; HUMANS; IMMUNIZATION, SECONDARY; IMMUNOGLOBULIN A; MIDDLE AGED; SALIVA; STREPTOCOCCAL VACCINES; STREPTOCOCCUS MUTANS;

EID: 33747620721     PISSN: 09020055     EISSN: 1399302X     Source Type: Journal    
DOI: 10.1111/j.1399-302X.2006.00302.x     Document Type: Article

References (28)

1. Brandtzaeg P, Baekkevold ES, Farstad IN, Jahnsen FL, Johansen F-E, Nilsen EM, Yamanaka T. Regional specialization in the mucosal immune system: what happens in the microcompartments? Immunol Today 1999: 20: 141-151.
2. Challacombe SJ, Percival RS, Marsh PD. Age-related changes in immunoglobulin isotypes in whole and parotid saliva and serum in healthy individuals. Oral Microbiol Immunol 1995: 10: 202-207.
3. Childers NK, Miller KL, Tong G, Llarena JC, Greenway T, Ulrich JT, Michalek SM. Adjuvant activity of monophosphoryl lipid A for nasal and oral immunization with soluble or liposome-associated antigen. Infect Immun 2000: 68: 5509-5516.
4. Childers NK, Tong G, Li F, Dasanayake AP, Kirk K, Michalek SM. Humans immunized with Streptococcus mutans antigens by mucosal routes. J Dent Res 2002: 81: 48-52.
5. Childers NK, Tong G, Michalek SM. Nasal immunization of humans with dehydrated liposomes containing Streptococcus mutans antigen. Oral Microbiol Immunol 1997: 12: 329-335.
6. Childers NK, Tong G, Mitchell S, Kirk K, Russell MW, Michalek SM. A controlled clinical study of the effect of nasal immunization with a Streptococcus mutans antigen alone or incorporated into liposomes on induction of immune responses. Infect Immun 1999: 67: 618-623.
7. Childers NK, Zhang SS, Harokopakis E, Harmon CC, Michalek SM. Properties of practical oral liposome Streptococcus mutans glucosyltransferase vaccines for effective induction of caries protection. Oral Microbiol Immunol 1996: 11: 172-180.
8. Childers NK, Zhang SS, Michalek SM. Oral immunization of humans with dehydrated liposomes containing Streptococcus mutans glucosyltransferase induces salivary immunoglobulin A2 antibody responses. Oral Microbiol Immunol 1994: 9: 146-153.
9. Fukuizumi T, Inoue H, Anzai Y, Tsujisawa T, Uchiyama C. Sheep red blood cell instillation at palatine tonsil effectively induces specific IgA class antibody in saliva in rabbits. Microbiol Immunol 1995: 39: 351-359.
10. Fukuizumi T, Inoue H, Tsujisawa T, Uchiyama C. Streptococcus sobrinus antigens that react to salivary antibodies induced by tonsillar application of formalin-killed S. sobrinus in rabbits. Infect Immun 2000: 68: 725-731.
11. Fukuizumi T, Inoue H, Tsujisawa T, Uchiyama C. Tonsillar application of formalin-killed cells of Streptococcus sobrinus reduces experimental dental caries in rabbits. Infect Immun 1999: 67: 426-428.
12. Fukuizumi T, Inoue H, Tsujisawa T, Uchiyama C. Tonsillar application of killed Streptococcus mutans induces specific antibodies in rabbit saliva and blood plasma without inducing a cross-reacting antibody to human cardiac muscle. Infect Immun 1997: 65: 4558-4563.
13. Kantele A, Hakkinen M, Moldoveanu Z, Lu A, Savilahti E, Alvarez RD, Michalek S, Mestecky J. Differences in immune responses induced by oral and rectal immunizations with Salmonella typhi Ty21a: evidence for compartmentalization within the common mucosal immune system in humans. Infect Immun 1998: 66: 5630-5635.
14. Katz J, Russell MW, Harmon CC, Buckner GP, White PL, Richardson GJ, Michalek SM. Induction of salivary IgA responses to Streptococcus mutans antigen I/II after intranasal immunization. Adv Exp Med Biol 1995: 371B: 1153-1156.
15. Li F, Michalek SM, Dasanayake AP, Li Y, Kirk K, Childers NK. Intranasal immunization of humans with Streptococcus mutans antigens. Oral Microbiol Immunol 2003: 18: 271-277.
16. Loesche WJ. Role of Streptococcus mutans in human dental decay. Microbiol Rev 1986: 50: 353-380.
17. Mestecky J. The common mucosal immune system and current strategies for induction of immune responses in external excretions. J Clin Immunol 1987: 7: 265-275.
18. Mestecky J, McGhee JR, Arnold RR, Michalek SM, Prince SJ, Babb JL. Selective induction of an immune response in human external secretions. J Clin Invest 1978: 61: 731-737.
19. Michalek SM, McGhee JR, Mestecky J, Arnold RR, Bozzo L. Ingestion of Streptococcus mutans induces secretory immunoglobulin A and caries immunity. Science 1976: 192: 1238-1240.
20. Russell MW, Childers NK, Michalek SM, Smith DJ, Taubman MA. A Caries vaccine? The state of the science of immunization against dental caries. Caries Res 2004: 38: 230-235.
21. Schaefer ME, Rhodes M, Prince S, Michalek SM, McGhee JR. A plastic intraoral device for the collection of human parotid saliva. J Dent Res 1977: 56: 728-733.
22. Scheie AA. The role of antimicrobials. In: Fejerskov O, Kidd EAM, ed. Dental caries: the disease and its clinical management. Oxford: Blackwell Munksgaard, 2003: 179-188.
23. Smith DJ. Dental caries vaccines: prospects and concerns. Crit Rev Oral Biol Med 2002: 13: 335-349.
24. Smith DJ, King WF, Barnes LA, Peacock Z, Taubman MA. Immunogenicity and protective immunity induced by synthetic peptides associated with putative immunodominant regions of Streptococcus mutans glucan-binding protein B. Infect Immun 2003: 71: 1179-1184.
25. Smith DJ, Taubman MA. Effect of local deposition of antigen on salivary immune responses and reaccumulation of mutans streptococci. J Clin Immunol 1990: 10: 273-281.
26. Smith DJ, Taubman MA. Oral immunization of humans with Streptococcus sobrinus glucosyltransferase. Infect Immun 1987: 55: 2562-2569.
27. Smith DJ, Taubman MA, Ebersole JL. Ontogeny and senescence of salivary immunity. J Dent Res 1987: 66: 451-456.
28. Tinanoff N. The early childhood caries conference-October 18-19, 1997. Pediatr Dent 1997: 19: 453-454.