Model of radiation-impaired healing of a deep excisional wound

Wound Repair and Regeneration

Volumn 14, Issue 4, 2006, Pages 498-505

  Werier, Joel ^a   Ferguson, Peter ^b   Bell, Robert ^b   Hill, Richard ^c   Wunder, Jay ^b   O'Sullivan, Brian ^c   Kandel, Rita ^b  

^a UNIVERSITY OF OTTAWA   (Canada)

^b MOUNT SINAI HOSPITAL   (Canada)

^c PRINCESS MARGARET HOSPITAL   (Canada)

Author keywords

[No Author keywords available]

Indexed keywords

BIOMATERIAL;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; CONTROLLED STUDY; DISEASE MODEL; FEMALE; IONIZING RADIATION; IRRADIATION; NONHUMAN; PRIORITY JOURNAL; RADIATION DOSE; RADIATION EXPOSURE; RADIATION INJURY; RAT; REPRODUCIBILITY; SKIN INJURY; SMALL INTESTINE; SUBMUCOSA; WOUND HEALING IMPAIRMENT;

ANIMALS; BIOLOGICAL DRESSINGS; DISEASE MODELS, ANIMAL; FASCIA; FEMALE; RADIOTHERAPY; RATS; RATS, INBRED LEW; WOUND HEALING; WOUNDS, PENETRATING;

EID: 33747608374     PISSN: 10671927     EISSN: 1524475X     Source Type: Journal    
DOI: 10.1111/j.1743-6109.2006.00145.x     Document Type: Article

References (60)

1. Robinson MH, Keus RB, Shasha D, Harrison LB. Is preoperative radiotherapy superior to postoperative radiotherapy in the treatment of soft tissue sarcoma? Eur J Cancer 1998; 34: 1309-16.
2. Suit H, Spiro IJ. Soft tissue sarcomas: radiation as a therapeutic option. Ann Acad Med Singapore 1996; 25: 855-61.
3. Spiro IJ, Rosenberg AE, Springfield D, Suit H. Combined surgery and radiation therapy for limb preservation in soft tissue sarcoma of the extremity: the Massachusetts general hospital experience. Cancer Invest 1995; 13: 86-95.
4. Alho A, Alvegard TA, Berlin O, Ranstam J, Rydholm A, Rooser B, Stener B. Surgical margin in soft tissue sarcoma. The Scandinavian Sarcoma Group experience. Acta Orthop Scand 1989; 60: 687-92.
5. Stotter A, McLean NR, Fallowfield ME, Breach NM, Westbury G. Reconstruction after excision of soft tissue sarcomas of the limbs and trunk. Br J Surg 1988; 75: 774-8.
6. Suit HD, Spiro I. Role of radiation in the management of adult patients with sarcoma of soft tissue. Semin Surg Oncol 1994; 10: 347-56.
7. Tepper JE, Suit HD. Radiation therapy of soft tissue sarcomas. Cancer 1985; 55 (Suppl.): 2273-7.
8. Suit HD, Proppe KH, Mankin HJ, Wood WC. Preoperative radiation therapy for sarcoma of soft tissue. Cancer 1981; 47: 2269-74.
9. Bell RS, O'Sullivan B, Langer F, Mahoney JL, Lichtenstein SV, Moffat FL, Cummings BJ, Hawkins NV, Fornasier VL. Complications and functional results after limb-salvage surgery and radiotherapy for difficult mesenchymal neoplasms: a prospective analysis. Can J Surg 1989; 32: 69-73.
10. Bell RS, O'Sullivan B, Davis A, Langer F, Cummings B, Fornasier VL. Functional outcome in patients treated with surgery and irradiation for soft tissue tumours. J Surg Oncol 1991; 48: 224-31.
11. Ngan SY. Radiotherapy in soft tissue sarcoma of the extremities. Acta Orthop Scand 1997; 273 (Suppl.): 112-6.
12. Nielsen OS, Cummings B, O'Sullivan B, Catton C, Bell RS, Fornasier VL. Preoperative and postoperative irradiation of soft tissue sarcomas: effect of radiation field size. Int J Radiat Oncol Biol Phys 1991; 21: 1595-9.
13. Cheng EY, Dusenbery KE, Winters MR, Thompson RC. Soft tissue sarcomas: preoperative versus postoperative radiotherapy. J Surg Oncol 1996; 61: 90-9.
14. Sadoski C, Suit HD, Rosenberg A, Mankin H, Efird J. Preoperative radiation, surgical margins and local control of extremity sarcomas of soft tissues. J Surg Oncol 1993; 52: 223-30.
15. Wilson AN, Davis A, Bell RS, O'Sullivan B, Catton C, Madadi F, Kandel R, Fornasier VL. Local control of soft tissue sarcoma of the extremity: the experience of a multidisciplinary sarcoma group with definitive surgery and radiotherapy. Eur J Cancer 1994; 30A: 746-51.
16. Tokarek R, Bernstein EF, Sullivan F, Uitto J, Mitchell JB. Effect of therapeutic radiation on wound healing. Clin Dermatol 1994; 12: 57-70.
17. Karasek K, Constine LS, Rosier R. Sarcoma therapy: functional outcome and relationship to treatment parameters. Int J Radiat Oncol Biol Phys 1992; 24: 651-6.
18. Peat BG, Bell RS, Davis A, O'Sullivan B, Mahoney J, Manktelow RT, Bowen V, Catton C, Fornasier VL, Langer F. Wound-healing complications after soft-tissue sarcoma surgery. Plast Reconstr Surg 1994; 93: 980-7.
19. Bujko K, Suit HD, Springfield DS, Convery K. Wound healing after preoperative radiation for sarcoma of soft tissues. Surg Gynecol Obstet 1993; 176: 124-34.
20. Saddegh MK, Bauer HC. Wound complication in surgery of soft tissue sarcoma. Analysis of 103 consecutive patients managed without adjuvant therapy. Clin Orthop 1993; 289: 247-53.
21. Skibber JM, Lotze MT, Seipp CA, Salcedo R, Rosenberg SA. Limb-sparing surgery for soft tissue sarcomas: wound related morbidity in patients undergoing wide local excision. Surgery 1987; 102: 447-52.
22. Quill G, Gitelis S, Morton T, Piasecki P. Complications associated with limb salvage for extremity sarcomas and their management. Clin Orthop 1990; 260: 242-50.
23. O'Sullivan B, Davis AM, Turcotte R, Bell R, Catton C, Chabot P, Wunder J, Kandel R, Goddard K, Sadura A, Pater J, Zee B. Preoperative versus postoperative radiotherapy in soft-tissue sarcoma of the limbs: a randomised trial. Lancet 2002; 359: 2235-41.
24. Davis A, O'Sullivan B, Bell R, Turcotte R, Catton C, Wunder J, Chabot P, Hammond A, Benk V, Isler M, Freeman C, Goddard K, Bezjak A, Kandel R, Sadura A, Day A, James K, Tu D, Pater J, Zee B. Function and health status outcomes in a randomized trial comparing preoperative and postoperative radiotherapy in extremity soft tissue sarcomas. J Clin Oncol 2002; 20: 4472-7.
25. Ferguson PC, Boynton EL, Wunder JS, Hill RP, O'Sullivan B, Sandhu JS, Bell RS. Intradermal injection of autologous dermal fibroblasts improves wound healing in irradiated skin. J Surg Res 1999; 85: 331-8.
26. Shalhav AL, Elbahnasy AM, Bercowsky E, Kovacs G, Brewer A, Maxwell KL, McDougall EM, Clayman RV. Laparoscopic replacement of urinary tract segments using biodegradable materials in a large-animal model. J Endourol 1999; 13: 241-4.
27. Hiles MC, Badylak SF, Lantz GC, Kokini K, Geddes LA, Morff RJ. Mechanical properties of xenogeneic small-intestinal submucosa when used as an aortic graft in the dog. J Biomed Mater Res 1995; 29: 883-91.
28. Chen M, Badylak SF. Small bowel tissue engineering using small intestinal submocusa as a scaffold. J Surg Res 2001; 99: 352-8.
29. Badylak S, Kokini K, Tullius B, Simmons-Byrd A, Morff R. Morphologic study of small intestinal submucosa as a body wall repair device. J Surg Res 2002; 103: 190-202.
30. Badylak S, Tullius R, Kokini K, Shelbourne K, Klootwyk T, Voytik S, Kraine M, Simmons C. The use of xenogenic small intestinal submucosa as a biomaterial for Achilles tendon repair in a dog model. J Biomed Mater Res 1995; 29: 977-85.
31. Dejardin LM, Arnoczky SP, Ewers BJ, Haut RC, Clarke RB. Tissue-engineered rotator cuff tendon using porcine small intestine submucosa. Histologic and mechanical evaluation in dogs. Am J Sports Med 2001; 29: 175-84.
32. Cobb MA, Badylak SF, Janas W, Boop FA. Histology after dural grafting with small intestinal submucosa. Surg Neurol 1996; 46: 389-93.
33. Hodde J, Record R, Liang H, Badylak S. Vascular endothelial growth factor in porcine-derived extracellular matrix. Endothelium 2001; 8: 11-24.
34. Allman AJ, McPherson TB, Badylak SF, Merrill LC, Kallakury B, Sheehan C, Raeder RH, Metzger DW. Xenogeneic extracellular matrix grafts elicit a TH2-restricted immune response. Transplantation 2001; 71: 1631-40.
35. McDevitt CA, Wildey GM, Cutrone RM. Transforming growth factor-beta1 in a sterilized tissue derived from the pig small intestine submucosa. J Biomed Mater Res 2003; 67A: 637-40.
36. Voytik-Harbin SL, Brightman AO, Kraine MR, Waisner B, Badylak SF. Identification of extractable growth factors from small intestinal submucosa. J Cell Biochem 1997; 67: 478-91.
37. Hodde JP, Hiles MC. Bioactive FGF-2 in sterilized extracellular matrix. Wounds 2001; 13: 195-201.
38. Badr el Din A, Coibion M, Guenier C, Nogaret JM, Lorent I, Van Houtte P, Tueni E, Mattheiem W. Local postoperative morbidity following pre-operative irradiation in locally advanced breast cancer. Eur J Surg Oncol 1989; 15: 486-9.
39. Guenier C, Coibion M, Badr el Din A, Nogaret JM, Lorent I, Toueni E, Vanhoute P, Mattheiem W. Morbidity of surgical treatment for advanced cancer of the breast after irradiation. Ann Chir 1990; 44: 392-5.
40. Griffin TW, Weisberger EC, Laramore GE, Tong D, Blasko JC. Complications of combined surgery and neutron radiation therapy in patients with advanced carcinoma of the head and neck. Radiology 1979; 132: 177-8.
41. Whiting JF, Howes A, Osteen RT. Preoperative irradiation for unresectable carcinoma of the rectum. Surg Gynecol Obstet 1993; 176: 203-7.
42. Gorodetsky R, Mou XD, Fisher DR, Taylor JM, Withers HR. Radiation effect in mouse skin: dose fractionation and wound healing. Int J Radiat Oncol Biol Phys 1990; 18: 1077-81.
43. Suit H, Spiro I. Preoperative radiation therapy for patients with sarcoma of the soft tissues. In: Verweij J, Pinedo H, Suit H, editors. Multidisciplinary treatment of soft tissue sarcomas. Norwell, MA: Kluwer Academic Publishers, 1993: 99-105.
44. Chow LW, Loo WT, Yuen KY, Cheng C. The study of cytokine dynamics at the operation site after mastectomy. Wound Rep Reg 2003; 11: 326-30.
45. Zhou LJ, Matsui R, Ono I. Development of a chronic skin defect model and a study of cytokine secretion using the model. Wound Rep Reg 2000; 8: 304-18.
46. Rudolph R, Vande Berg J, Schneider JA, Fisher JC, Poolman WL. Slowed growth of cultured fibroblasts from human radiation wounds. Plast Reconstr Surg 1988; 82: 669-77.
47. Lombard-Vignon N, Lafuma C, Godeau G, Masse R. Early modifications of outgrowth and metallo-endopeptidase activity in fibroblasts from rat cutaneous explants after local gamma-iradiation: dermis cellularity and collagen fibre alterations. Int J Radiat Biol 1990; 58: 325-40.
48. De Loecker W, Van der Schueren E, Stas ML, Doms D. The effects of x-irradiation on collagen metabolism in rat skin. Int J Radiat Biol Relat Stud Phys Chem Med 1976; 29: 351-8.
49. Wang Q, Dickson GR, Abram WP, Carr KE. Electron irradiation slows down wound repair in rat skin: a morphological investigation. Br J Dermatol 1994; 130: 551-60.
50. Dantzer D, Ferguson P, Hill RP, Keating A, Kandel RA, Wunder JS, O'Sullivan B, Sandhu J, Waddell J, Bell RS. Effect of radiation and cell implantation on wound healing in a rat model. J Surg Oncol 2003; 83: 185-90.
51. Clark R. Wound Repair: overview and general considerations. In: Clark RA, editor. The molecular and cellular biology of wound repair. New York: Plenum Press, 1996: 3-50.
52. Springfield D. Surgical wound healing. In: Verweij J, Pinedo H, Suit H, editors. Multidisciplinary treatment of soft tissue sarcomas. Norwell, MA: Kluwer Academic Publishers, 1993.
53. Fu K. Normal tissue effects of combined radiotherapy and chemotherapy for head and neck cancer. Front Radiat Ther Oncol 1979; 13: 113-32.
54. Ariyan S, Marfuggi RA, Harder G, Goodie MM. An experimental model to determine the effects of adjuvant therapy on the incidence of postoperative wound infection: I. Evaluating preoperative radiation therapy. Plast Reconstr Surg 1980; 65: 328-37.
55. Langstein HN, Chang DW, Miller MJ, Evans GR, Reece GP, Kroll SS, Robb GL. Limb salvage for soft-tissue malignancies of the foot: an evaluation of free-tissue transfer. Plast Reconstr Surg 2002; 109: 152-9.
56. Lane Jr, Gibbs J, McGrath B, Loree T, Kraybill W. Large, deep high-grade extremity sarcomas: when is a myocutaneous flap reconstruction necessary? Surg Oncol 1999; 8: 205-10.
57. Kunisada T, Ngan SY, Powell G, Choong P. Wound complications following pre-operative radiotherapy for soft tissue sarcoma. Eur J Surg Oncol 2002; 28: 75-9.
58. Gu Y, Dai K. Substitution of porcine small intestinal submucosa for rabbit Achilles tendon, an experimental study. Zhonghua Yi Xue Za Zhi 2002; 82: 1279-82.
59. Prevel C, Eppley BL, Summerlin DJ, Sidner R, Jackson JR, McCarty M, Badylak SF. Small intestinal submucosa: utilization as a wound dressing in full-thickness rodent wounds. Ann Plast Surg 1995; 35: 381-8.
60. Xie H, Shaffer BS, Wadia Y, Gregory KW. Use of reconstructed small intestine submucosa for urinary tract replacement. ASAIO J 2000; 46: 268-72.