Point of care management of heparin administration after heart surgery: A randomized, controlled trial

Intensive Care Medicine

Volumn 32, Issue 9, 2006, Pages 1357-1364

  Merlani, Paolo G ^a   Chenaud, Catherine ^a   Cottini, Silvia ^a   Reber, Guido ^a   Garnerin, Philippe ^a   De Moerloose, Philippe ^a   Ricou, Bara ^a  

^a GENEVA UNIVERSITY HOSPITALS   (Switzerland)

Author keywords

Cardiac surgery; Coagulation; Intensive care unit; Quality

Indexed keywords

HEPARIN;

ADULT; ANTICOAGULATION; ARTICLE; BLEEDING; BLOOD TRANSFUSION; CLINICAL ARTICLE; CLINICAL TRIAL; CONTROLLED CLINICAL TRIAL; CONTROLLED STUDY; CORONARY ARTERY BYPASS GRAFT; DIAGNOSTIC VALUE; EARLY DIAGNOSIS; FEMALE; HEALTH CARE QUALITY; HEART SURGERY; HEART VALVE SURGERY; HUMAN; INTERMETHOD COMPARISON; LABORATORY DIAGNOSIS; MALE; PARTIAL THROMBOPLASTIN TIME; POINT OF CARE TESTING; POSTOPERATIVE PERIOD; RANDOMIZED CONTROLLED TRIAL; THROMBOSIS;

BLOOD COAGULATION DISORDERS; CARDIAC SURGICAL PROCEDURES; DRUG ADMINISTRATION SCHEDULE; ERYTHROCYTE TRANSFUSION; HEPARIN; HUMANS; PARTIAL THROMBOPLASTIN TIME; POINT-OF-CARE SYSTEMS; POSTOPERATIVE COMPLICATIONS; POSTOPERATIVE HEMORRHAGE; REGRESSION ANALYSIS; TIME FACTORS; TREATMENT OUTCOME;

EID: 33747602994     PISSN: 03424642     EISSN: None     Source Type: Journal    
DOI: 10.1007/s00134-006-0220-8     Document Type: Article

References (22)

1. Despotis GJ, Goodnough LT (2000) Management approaches to platelet-related microvascular bleeding in cardiothoracic surgery. Ann Thorac Surg 70:S20-32
2. Becker RC, Cyr J, Corrao JM, Ball SP (1994) Bedside coagulation monitoring in heparin-treated patients with active thromboembolic disease - a coronarycare unit experience. Am Heart J 128:719-723
3. Reiner JS, Coyne KS, Lundergan CF, Ross AM (1994) Bedside monitoring of heparin-therapy - comparison of activated clotting time to activated partial thromboplastin time. Cath Cardiovasc Diag 32:49-52
4. Ruzicka K, Kapiotis S, Quehenberger P, Handler S, Hornykewycz S, Michitsch A, Huber K, Clemens D, Susan M, Pabinger I, Eichinger S, Jilma B, Speiser W (1997) Evaluation of bedside prothrombin time and activated partial thromboplastin time measurement by coagulation analyzer CoaguChek Plus(R) in various clinical settings. Thromb Res 87:431-440
5. Solomon HM, Mullins RE, Lyden P, Thompson P, Hudoff S (1998) The diagnostic accuracy of bedside and laboratory coagulation - procedures used to monitor the anticoagulation status of patients treated with heparin. Am J Clin Pathol 109:371-378
6. Nuttall GA, Oliver WC Jr., Beynen FM, Dull JJ, Murray MJ, Nichols WL (1993) Intraoperative measurement of activated partial thromboplastin time and prothrombin time by a portable laser photometer in patients following cardiopulmonary bypass. J Cardiothorac Vasc Anesth 7:402-409
7. Ferring M, Reber G, de Moerloose P, Merlani P, Diby M, Ricou B (2001) Point of care and central laboratory determinations of the aPTT are not interchangeable in surgical intensive care patients. Can J Anaesth 48:1155-1160
8. Nuttall GA, Oliver WC, Beynen FM, Santrach PJ, Strickland RA, Murray MJ (1995) Determination of normal versus abnormal activated partial thromboplastin time and prothrombin time after cardiopulmonary bypass. J Cardiothorac Vasc Anesth 9:355-361
9. Merlani P, Chenaud C, Cottini S, Reber G, De Moerloose P, Ricou B (2003) RCT of coagulation management by point of care vs. laboratory aPTT after cardiopulmonary bypass. Intensive Care Med 29:S115-S115
10. Capraro L, Kuitunen A, Salmenpera M, Kekomaki R (2001) On-site coagulation monitoring does not affect hemostatic outcome after cardiac surgery. Acta Anaesthesiol Scand 45:200-206
11. Despotis GJ, Levine V, Saleem R, Spitznagel E, Joist JH (1999) Use of point-of-care test in identification of patients who can benefit from desmopressin during cardiac surgery: a randomised controlled trial. Lancet 354:106-110
12. Despotis GJ, Santoro SA, Spitznagel E, Kater KM, Cox JL, Barnes P, Lappas DG (1994) Prospective evaluation and clinical utility of on-site monitoring of coagulation in patients undergoing cardiac operation. J Thorac Cardiovasc Surg 107:271-279
13. Nuttall GA, Oliver WC, Santrach PJ, Bryant S, Dearani JA, Schaff HV, Ereth MH (2001) Efficacy of a simple intraoperative transfusion algorithm for nonerythrocyte component utilization after cardiopulmonary bypass. Anesthesiology 94:773-781; discussion 775A-776A
14. Avidan MS, Alcock EL, Da Fonseca J, Ponte J, Desai JB, Despotis GJ, Hunt BJ (2004) Comparison of structured use of routine laboratory tests or near-patient assessment with clinical judgement in the management of bleeding after cardiac surgery. Br J Anaesth 92:178-186
15. Miller BE, Mochizuki T, Levy JH, Bailey JM, Tosone SR, Tam VK, Kanter KR (1997) Predicting and treating coagulopathies after cardiopulmonary bypass in children. Anesth Analg 85:1196-1202
16. Tuman KJ, Spiess BD, McCarthy RJ, Ivankovich AD (1989) Comparison of viscoelastic measures of coagulation after cardiopulmonary bypass. Anesth Analg 69:69-75
17. Bonow RO, Carabello B, de Leon AC Jr, Edmunds LH Jr, Fedderly BJ, Freed MD, Gaasch WH, McKay CR, Nishimura RA, O'Gara PT, O'Rourke RA, Rahimtoola SH, Ritchie JL, Cheitlin MD, Eagle KA, Gardner TJ, Garson A Jr, Gibbons RJ, Russell RO, Ryan TJ, Smith SC Jr (1998) Guidelines for the management of patients with valvular heart disease: executive summary. A report of the American College of Cardiology/American Heart Association Task Force on Practice Guidelines. Circulation 98:1949
18. Gohlke-Barwolf C, Acar J, Oakley C, Butchart E, Burckhart D, Bodnar E, Hall R, Delahaye JP, Horstkotte D, Kremer R, et al. (1995) Guidelines for prevention of thromboembolic events in valvular heart disease. Study Group of the Working Group on Valvular Heart Disease of the European Society of Cardiology. Eur Heart J 16:1320-1330
19. Kvasnicka J, Krska Z, Tosovsky J, Vackova I, Maslowska H (1993) Increase in fibrinogenemia in the postoperative period of open-heart surgery. Cor Vasa 35:194-199
20. Cannegieter SC, Rosendaal FR, Briet E (1994) Thromboembolic and bleeding complications in patients with mechanical heart valve prostheses. Circulation 89:635-641
21. Geiser T, Sturzenegger M, Genewein U, Haeberli A, Beer JH (1998) Mechanisms of cerebrovascular events as assessed by procoagulant activity, cerebral microemboli, and platelet microparticles in patients with prosthetic heart valves. Stroke 29:1770
22. Libman RB, Wirkowski E, Neystat M, Barr W, Gelb S, Graver M (1997) Stroke associated with cardiac surgery - determinants, timing, and stroke subtypes. Arch Neurol 54:83-87