A confidence interval for the maximal mean QT interval change caused by drug effect

Drug Information Journal

Volumn 40, Issue 3, 2006, Pages 267-271

  Eaton, Morris L ^a   Muirhead, Robb J ^b   Mancuso, Jessica Y ^b   Kolluri, Sheela ^b  

^a UNIVERSITY OF MINNESOTA   (United States)

^b PFIZER GLOBAL RESEARCH AND DEVELOPMENT   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

DRUG; PLACEBO;

ARTICLE; CONFIDENCE INTERVAL; DRUG EFFECT; DRUG SCREENING; PRIORITY JOURNAL; PROBABILITY; QT INTERVAL; QT PROLONGATION; SAMPLING; STATISTICAL ANALYSIS;

EID: 33747589471     PISSN: 00928615     EISSN: None     Source Type: Journal    
DOI: 10.1177/009286150604000304     Document Type: Article

References (3)

1. International Conference on Harmonisation. ICH (E14) Guidance. The Clinical Evaluation of QT/QTc Interval Prolongation and Proarrhythmic Potential for Non-Antiarrhythmic Drugs. Geneva, Switzerland: International Conference on Harmonisation; May 2005.
2. Eaton ML, Muirhead RJ. An approximate confidence interval for the maximum coordinate of a mean vector. Pfizer Technical Report. Available from the authors. 2004.
3. Chung KL. A Course in Probability Theory. 2nd ed. New York: Academic Press; 1974.