Assessment of methyl methacrylate vapor toxicity on the rat tracheal epithelium;Análise da toxicidade dos vapores de metil metacrilato sobre o epitélio traqueal de ratos

Brazilian Oral Research

Volumn 19, Issue 3, 2005, Pages 223-227

  Parizi, José Luiz Santos ^a   Nai, Gisele Alborghetti ^a   Batalha, Camila Fedatto ^b   Lopes, Carla Cristina Barbosa ^a   Rizzo, Mariana Fernandez ^b   Falcone, Ciro Eduardo ^a   Bertão, José Maria ^a  

^a SÃO PAULO STATE UNIVERSITY UNESP   (Brazil)

^b Graduate Program in Dentistry   (Brazil)

Author keywords

Methylmethacrylate; Toxicity; Trachea

Indexed keywords

BIOMEDICAL AND DENTAL MATERIALS; METHACRYLIC ACID METHYL ESTER;

ANIMAL; ARTICLE; DRUG EFFECT; EPITHELIUM; FEMALE; GAS; INHALATIONAL DRUG ADMINISTRATION; MALE; PATHOLOGY; RAT; TIME; TOOTH PROSTHESIS; TRACHEA; WISTAR RAT;

ADMINISTRATION, INHALATION; ANIMALS; DENTAL MATERIALS; DENTAL PROSTHESIS; EPITHELIUM; FEMALE; GASES; MALE; METHYLMETHACRYLATE; RATS; RATS, WISTAR; TIME FACTORS; TRACHEA;

EID: 33747572316     PISSN: 18068324     EISSN: 18073107     Source Type: Journal    
DOI: 10.1590/S1806-83242005000300012     Document Type: Article

References (22)

1. Aydin O, Attila G, Dogan A, Aydin MV, Canacankatan N, Kanik A. The effects of methyl methacrylate on nasal cavity, lung, and antioxidant system (an experimental inhalation study). Toxicol Pathol 2002;30(3):350-6.
2. Barash PG. Preparação para a anestesia. In: Manual de anestesiologia clínica. São Paulo: Manole; 1991. p. 45.
3. Bogdanffy MF, Randall HW, Morgan KT. Biochemical quantitation and histochemical localization of carboxylesterase in the nasal passages of the Fischer-344 rat and B6C3F1 mouse. Toxicol Appl Pharmacol 1987;88:183-94.
4. Deichmann W. Toxicity of methyl, ethyl and butyl methacrylate. J Ind Hyg Toxicol 1941;23(7):343-51.
5. Donaghy M, Rushworth G, Jacobs JM. Generalized peripheral neuropathy in a dental technician exposed to methyl methacrylate monomer. Neurology 1991;41:1112-6.
6. Gaskell BA, Hext PM, Pigott GH, Hodge MC, Tinston DJ. Olfactory and hepatic changes following inhalation of 3-trifluoromethyl pyridine in rats. Toxicology 1988;50:57-69.
7. Hext PM, Pinto PJ, Gaskell BA. Methyl methacrylate in rat nasal epithelium: investigation of the time course of lesion development and recovery from short term vapor inhalation. Toxicology 2001;156:119-28.
8. Hochman N, Zalkind M. Hypersensitivity to methyl methacrylate: mode of treatment. J Prosthet Dent 1997;77:93-6.
9. Holland CJ, Kim KC, Malik MI, Ritter MA. A histologic and hemodynamic study of the toxic effects of monomeric methyl methacrylate. Clin Orthop Relat Res 1973;90:262-70.
10. Hurtt ME, Morgan KT, Working PK. Histopathology of acute toxic responses in selected tissues from rats exposed by inhalation to methyl bromide. Fundam Appl Toxicol 1987;9:352-65.
11. Lomax LG, Krivanek ND, Frame SR. Chronic inhalation toxicity and oncogenicity of methyl methacrylate in rats and hamsters. Food Chem Toxicol 1997;35:393-407.
12. Lönnroth EC, Shahnavaz H. Use of polymer materials in dental clinics, case study. Sweed Dent J 1997;21:149-59.
13. Mainwaring G, Foster JR, Lund V, Green T. Methyl methacrylate toxicity in rat nasal epithelium: studies of the mechanism of action and comparisons between species. Toxicology 2001;158:109-18.
14. McLaughlin RE, Barkalow JA. Pulmonary toxicity of methyl methacrylate vapors: an environmental study. Arch Environ Health 1979;34(5):336-8.
15. Miller RR, Young JT, Kociba RJ, Keyes DG, Bodner KM, Calhoun LL, et al. Chronic toxicity and oncogenicity bioassay of inhaled ethyl acrylate in Fischer 344 rats and B6C3F1 mice. Drug Chem Toxicol 1985;8:1-42.
16. Mizunuma K, Kawai T, Yasugi T, Horigushi S, Takeda S, Miyashita K, et al. Biological monitoring and possible health effects in workers occupationally exposed to methyl methacrylate. Int Arch Occup Environ Health 1993;65:227-32.
17. Olson MJ, Martin JL, LaRosa AC, Brady AN, Pohl LR. Immunohistochemical localization of carboxylesterase in the nasal mucosa of rats. J Histochem Cytochem 1993;41:307-11.
18. Reininghaus W, Koestner A, Klimisch HJ. Chronic toxicity and oncogenicity of inhaled methyl acrylate and nbutyl acrylate in Sprague-Dawley rats. Food Chem Toxicol 1991;29:329-40.
19. Solomon HM, McLaughlin JE, Swenson RE, Hagan JV, Wanner FJ, O'Hara GP, et al. Methyl methacrylate: inhalation developmental toxicity study in rats. Teratology 1993;48:115-25.
20. Tansy MF, Hohenleitner FJ, White DK, Oberly R, Landin WE, Kendal FM. Chronic biological effects of methyl methacrylate vapor. III. Histopathology, blood chemistries, and hepatic and ciliary function in the rat. Environ Res 1980;21:117-25.
21. Tansy MF, Kendall FM. Update on the toxicity of inhaled methyl methacrylate vapor. Drug Chem Toxicol 1979;2(4):315-30.
22. Wittczak T, Palczynski C, Szulc B, Gorski P. Bronchial asthma with inflammation of the nose mucous membrane induced by occupational exposure to methyl methacrylate in a dental technician. Med Pr 1996;47:259-66.