Association of paradoxical sleep deprivation and ecstasy (MDMA) enhances genital reflexes in male rats

Behavioural Brain Research

Volumn 170, Issue 2, 2006, Pages 287-292

  Andersen, M L ^a   Perry, J C ^a   Battisti, M C ^a   Calzavara, M B ^a   Costa, J L ^b   Neto, O N ^b   Frussa Filho, R ^a   Tufik, S ^a  

^a FEDERAL UNIVERSITY OF SÃO PAULO   (Brazil)

^b Instrumental Analysis Laboratory   (Brazil)

Author keywords

Cocaine; Ecstasy; Ejaculation; Erection; Serotonin; Sleep deprivation

Indexed keywords

3,4 METHYLENEDIOXYMETHAMPHETAMINE; COCAINE; ILLICIT DRUG; SODIUM CHLORIDE;

ANIMAL EXPERIMENT; ARTICLE; COMPARATIVE STUDY; CONTROLLED STUDY; DOSE CALCULATION; DRUG EFFECT; EJACULATION; MALE; NONHUMAN; PENIS ERECTION; PRIORITY JOURNAL; RAT; REM SLEEP DEPRIVATION; SEROTONINERGIC NERVE CELL; SLEEP DEPRIVATION;

ADRENERGIC UPTAKE INHIBITORS; ANALYSIS OF VARIANCE; ANIMALS; COCAINE; DOPAMINE UPTAKE INHIBITORS; DOSE-RESPONSE RELATIONSHIP, DRUG; EJACULATION; MALE; N-METHYL-3,4-METHYLENEDIOXYAMPHETAMINE; PENILE ERECTION; RATS; RATS, WISTAR; SLEEP DEPRIVATION; SLEEP, REM;

EID: 33747485298     PISSN: 01664328     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.bbr.2006.03.005     Document Type: Article

References (46)

1. Adams D.H., Hanson G.R., and Keefe K.A. Differential effects of cocaine and methamphetamine on neurotensin/neuromedin N and preprotachykinin messenger RNA expression in unique regions of the striatum. Neuroscience 102 (2001) 843-851
2. Almeida S.P., and Silva M.T.A. Ecstasy (MDMA): effects and patterns of use reported by users in São Paulo. Rev Brasil Psiquiatria 25 (2003) 11-17
3. Andersen M.L., Bignotto M., and Tufik S. Facilitation of ejaculation after methamphetamine administration in paradoxical sleep deprived rats. Brain Res 978 (2003) 31-37
4. Andersen M.L., Bignotto M., and Tufik S. Cocaine-induced genital reflexes during paradoxical sleep deprivation and recovery. Physiol Behav 78 (2003) 255-259
5. Andersen M.L., D'Almeida V., Ko G.M., Kawakami R., Martins P.J.F., Magalhães L.E., et al. Experimental procedure. Ethical and practical principles of the use of laboratory animals (2004), Univ. Fed. São Paulo, São Paulo, Brazil 45-69
6. Andersen M.L., Perry J.C., and Tufik S. Acute cocaine effects in paradoxical sleep deprived male rats. Prog Neuro-Psychopharmacol Biol Psych 29 (2005) 245-251
7. Andersen M.L., Martins P.J.F., D'Almeida V., Bignotto M., and Tufik S. Endocrinological alterations during sleep deprivation and recovery in male rats. J Sleep Res 14 (2005) 83-90
8. Andersen M.L., Papale L.A., Hipólide D.C., Nobrega J., and Tufik S. Involvement of dopamine receptors in cocaine-induced genital reflexes after paradoxical sleep deprivation. Behav Brain Res 160 (2005) 44-50
9. Andersen M.L., Antunes I.B., and Tufik S. Effects of paradoxical sleep deprivation on genital reflexes in five rat strains. Horm Behav 49 (2006) 173-180
10. Andersen M.L., and Tufik S. Premature ejaculation - dopaminergic control of ejaculation. Drug Discov Today: Ther Strategies 2 (2005) 41-46
11. Antunes I.B., Andersen M.L., Baracat E., and Tufik S. The effects of paradoxical sleep deprivation on estrous cycles of the female rats. Horm Behav 47 (2006) 433-440
12. Bengel D., Murphy D.L., Andrews A.M., Wichems C.H., Feltner D., Heils A., et al. Altered brain serotonin homeostasis and locomotor insensitivity to 3,4-methylenedioxymethamphetamine ("Ecstasy") in serotonin transporter-deficient mice. Mol Pharmacol 53 (1998) 649-655
13. Bilsky E.J., Hubbell C.L., Delconte J.D., and Reid L.D. MDMA produced a conditioned place preference and elicits ejaculation in male rats: a modulatory role for the endogenous opioids. Pharmacol Biochem Behav 40 (1991) 443-447
14. Boyd C.J., McCabe S.E., and d'Arcy H. Ecstasy use among college undergraduates: gender, RACE and sexual identity. J Subst Abuse Treat 24 (2003) 209-215
15. Buffum J., and Moser C. MDMA and human sexual function. J Psychoactive Drugs 18 4 (1986) 355-359
16. Christophersen A.S. Amphetamine designer drugs - an overview and epidemiology. Toxicol Lett 112-113 (2000) 127-131
17. de Paula H.M.G., and Hoshino K. Correlation between the fighting rates of REM sleep-deprived rats and susceptibility to the "wild running" of audiogenic seizures. Brain Res 926 (2002) 80-85
18. Dornan W.A., Katz J.L., and Ricaurte G.A. The effects of repeated administration of MDMA on the expression of sexual behavior in the male rat. Pharmacol Biochem Behav 39 (1991) 813-816
19. Foreman M.M., and Hall J.L. Effects of D2-dopaminergic receptor stimulation on male rat sexual behavior. J Neural Transm 68 (1987) 153-170
20. Frussa-Filho R., Gonçalves M.T.M., Andersen M.L., de Araujo N.P., Chinen C.C., and Tufik S. Paradoxical sleep deprivation potentiates amphetamine-induced behavioural sensitization by increasing its conditioned components. Brain Res 1003 (2004) 188-193
21. Green A.R., Cross A.J., and Goodwin G.M. Review of the pharmacology and clinical pharmacology of 3,4-methylenedioxymethamphetamine (MDMA or "ecstasy"). Psychopharmacology 119 (1995) 247-260
22. Green A.R., Sanchez V., O'Shea E., Saadat K.S., and Elliot J.M. Colado MIEffect of ambient temperature and a prior neurotoxic dose of 3,4-methylenedioxymethamphetamine (MDMA) on the hypertermic response of rats to a single or repeated ('binge' ingestion) low dose of MDMA. Psychopharmacology 173 (2004) 264-269
23. Gorzalka B.B., Mendelson S.D., and Watson N.V. Serotonin receptor subtypes and sexual behavior. Ann NY Acad Sci 600 (1990) 435-446
24. 3H]dopamine in rat brain tissue slices. Biochem Pharmacol 24 (1975) 847-852
25. Hipólide D.C., Moreira K.M., Wilson A.A., Barlow K., Nobrega J.N., and Tufik S. Distinct effects of sleep deprivation on binding to serotonin and norepinephrine transporter in rat brain. Prog Neuro-Psychopharmacol Biol Psych 29 (2005) 297-303
26. Iravani M.M., Asari D., Patel J., Weiczorek W.J., and Kruk Z.L. Direct effects of methylenedioxymethamphetamine (MDMA) on serotonin or dopamine release and uptake in the caudate putamen, nucleus accumbens, substantia nigra pars reticulata, and the dorsal raphe nucleus slices. Synapse 36 (2000) 275-285
27. Jacobsen L.K., Mencl W.E., Pugh K.R., Skudlarski P., and Krystal J.H. Preliminary evidence of hipocampal dysfunction in adolescent MDMA ("ecstasy") users: possible relationship to neurotoxic effects. Psychopharmacology 173 (2004) 383-390
28. Johanson C.E., Roehrs T., Schuh K., and Warbasse L. The effects of cocaine on mood and sleep in cocaine-dependent males. Exp Clin Psychopharmacol 7 (1999) 338-346
29. Koppel B.S., Samkoff L., and Daras M. Relation of cocaine use to seizures and epilepy. Epilepsia 37 (1996) 875-878
30. Nash J.F., and Brodklin J. Microdialysis studies on 3,4-thylenedioxymethamphetamine-induced dopamine release: effect of dopamine uptake inhibitors. J Pharmacol Exp Ther 259 (1991) 820-825
31. 2 dopaminergic receptors in rat brain after paradoxical sleep deprivation. Brain Res Bull 34 (1994) 453-456
32. Peñalva R.G., Lancel M., Flachskamm C., Reul J.M., Holsboer F., and Linthorst A.C. Effect of sleep and sleep deprivation on serotonergic neurotransmission in the hippocampus: a combined in vivo microdialysis/EEG study in rats. Eur J Neurosci 17 (2003) 1896-1906
33. Pope H.G., Ionescu-Pioggia M., and Pope K. Drug use and life style among college undergraduates: a 30-year longitudinal study. Am J Psychiatry 158 (2001) 1519-1521
34. O'Hearn E., Battaglia G., De Souza E.B., Kuhar M.J., and Molliver M.E. Methylenedioxyamphetamine (MDA) and methylenedioxymethamphetamine (MDMA) cause selective ablation of serotonergic axon terminals in forebrain: immunocytochemical evidence for neurotoxicity. J Neurosci 8 (1988) 2788-2803
35. Randall J. Ecstasy-fueled "rave" parties become dances of death for English youths. JAMA 268 (1992) 1505-1506
36. Randall J. Rave scene, ecstasy use, leap Atlantic. JAMA 268 (1992) 1506
37. Ricaurte G.A., McCann U.D., Szabo Z., and Scheffel U. Toxicodynamics and long-term toxicity of the recreatinional drug, 3,4-methylenedioxymethamphetamine (MDMA, "ecstasy"). Toxicol Lett 112-113 (2000) 143-146
38. Ricaurte G.A., Yuan J., Hatziditriou G., Cord B.J., and McCann U.D. Severe dopaminergic neurotoxicity in primates after a common recreational dose regimen of MDMA ("ecstasy"). Science 297 (2002) 2260-2263
39. Semple D.M., Ebmeier K.P., Glabus M.F., O'Carroll R.E., and Johnstone E.C. Reduced in vivo bonding to the serotonin transporter in the cerebral cortex of MDMA ("ecstasy") users. Br J Psychiatry 175 (1999) 63-69
40. Schmidt C.J. Neurotoxicity of the psychodelic amphetamine, methylenedioxymethamphetamine. J Pharmacol Exp Ther 240 (1987) 1-7
41. Schwartz R.H., and Miller N.S. MDMA (ecstasy) and rave: a review. Pediatrics 1000 (1997) 705-708
42. Simantov R. Multiple molecular and neuropharmacological effects of MDMA (Ecstasy). Life Sci 74 (2004) 803-814
43. Solowij N., Hall W., and Lee N. Recreational MDMA use in Sydney: a profile of "Ecstasy" users and their experiences with the drug. Br J Addict 87 (1992) 1161-1172
44. Tufik S., Lindsey C.J., and Carlini E.A. Does REM sleep deprivation induce a supersensitivity of dopaminergic receptors in the rat brain?. Pharmacology 16 (1978) 95-108
45. Tufik S., Troncone L.R.P., Braz S., Silva-Filho A.R., and Neumann B.G. Does REM sleep deprivation induce subsensitivity of presynaptic dopamine or postsynaptic acetylcholine receptors in the rat brain?. Eur J Pharmacol 140 (1987) 215-219
46. Yamamoto B.K., Nash J.F., and Gudelsky G.A. Modulation of methylenedioxymethamphetamine-induced striatal dopamine release by the interaction between serotonin and gamma-aminobutyric acid in the substantia nigra. J Pharmacol Exp Ther 273 (1995) 1063-1070