Endometrial cells in cervical cytology: Review of cytological features and clinical assessment

Journal of Lower Genital Tract Disease

Volumn 10, Issue 2, 2006, Pages 111-122

  Greenspan, David L ^a   Cardillo, Marina ^b   Davey, Diane D ^c   Heller, Debra S ^d   Moriarty, Ann T ^e  

^a UNIVERSITY OF ARIZONA COLLEGE OF MEDICINE   (United States)

^b QUEST DIAGNOSTICS NICHOLS INSTITUTE   (United States)

^c UNIVERSITY OF KENTUCKY MEDICAL CENTER   (United States)

^d RUTGERS NEW JERSEY MEDICAL SCHOOL   (United States)

^e Ameripath Inc   (United States)

Author keywords

Atypical glandular cells; Bethesda System; Cervical cytology(Pap test); Endometrial adenocarcinoma; Endometrial cells; Transvaginal ultrasound

Indexed keywords

ESTROGEN; MEDROXYPROGESTERONE ACETATE; ORAL CONTRACEPTIVE AGENT; TAMOXIFEN;

CANCER CYTODIAGNOSIS; CLINICAL PRACTICE; ENDOMETRIUM BIOPSY; ENDOMETRIUM CARCINOMA; ENDOMETRIUM CELL; ESTROGEN DEFICIENCY; ESTROGEN THERAPY; HORMONAL CONTRACEPTION; HORMONE SUBSTITUTION; HUMAN; INTRAUTERINE CONTRACEPTIVE DEVICE; MENOPAUSAL SYNDROME; MENSTRUAL CYCLE; ORAL CONTRACEPTION; PAPANICOLAOU TEST; POSTMENOPAUSE; PRACTICE GUIDELINE; PREMENOPAUSE; REVIEW; RISK FACTOR; STROMA CELL; TRANSVAGINAL ECHOGRAPHY; UTERINE CERVIX CYTOLOGY;

CONTRACEPTIVE AGENTS, FEMALE; DILATATION AND CURETTAGE; ENDOMETRIUM; ESTROGEN ANTAGONISTS; FEMALE; HORMONE REPLACEMENT THERAPY; HUMANS; MENSTRUAL CYCLE; PRACTICE GUIDELINES; PRECANCEROUS CONDITIONS; RISK FACTORS; STROMAL CELLS; TAMOXIFEN; UTERINE CERVICAL NEOPLASMS; VAGINAL SMEARS;

EID: 33747469453     PISSN: 10892591     EISSN: None     Source Type: Journal    
DOI: 10.1097/01.lgt.0000210130.01016.ad     Document Type: Review

References (67)

1. Solomon D, Davey D, Kurman R, Moriarty A, O'Connor D, Prey M, et al. The 2001 Bethesda System. Terminology for reporting cervical cytology. JAMA 2002;287:2114-9.
2. Mount SL, Wegner EK, Eltabbakh GH, Olmstead JI, Drejet AE. Significant increase of benign endometrial cells on Papanicolaou smears in women using hormone replacement therapy. Obstet Gynecol 2002;100:445-50.
3. Saad RS, Mahdavy M, Takei H, Ruiz B. Endometrial cells in cervical specimens of women 940 years of age (abstract). Acta Cytol 2004;48:678-9.
4. Bean S, Connolly K, Roberson J, et al. Incidence and clinical significance of normal endometrial cells in patients 40 years and older (abstract). Acta Cytol 2004;48:677.
5. Kerpsack JT, Finan MA, Kline RC. Correlation between endometrial cells on Papanicolaou smear and endometrial carcinoma. Southern Medical Journal 1998;91:749-52.
6. Thrall MJ, Kjeidahl KS, Savik K, Gulbahce HE, Pambuccian SE. Significance of benign endometrial cells in Papanicolaou Tests from women aged 940 years. Cancer Cytopathol 2005;105:207-16.
7. Cherkis RC, Patten SF, Andrews TJ, Dickinson JC, Patten FW. Significance of normal endometrial cells detected by cervical cytology. Obstet Gynecol 1988;71:242-4.
8. Webster SD, Cason Z, Lemos LB, Benghuzzi H. Cytohistologic correlation in patients with clinical symptoms of postmenopausal bleeding. Biomed Sci Instru 2000;36:367-72.
9. Davey DD, Neal MH, Wilbur DC, Colgan TJ, Styer PE, Mody DR. Bethesda 2001 implementation and reporting rates: 2003 practices of participants in the College of American Pathologists interlaboratory comparison program in cervicovaginal cytology. Arch Pathol Lab Med 2004;128:1224-9.
10. Chhieng DC, Elgert P, Cohen JM, Cangiarella JF. Clinical implications of atypical glandular cells of undetermined significance, favor endometrial origin. Cancer (Cancer Cytopathol) 2001;93:351-6.
11. Moriarty AT, Cibas ES. Endometrial cells: the how and when of reporting. In: Solomon D, Nayar R eds. The Bethesda System for Reporting Cervical Cytology, 2nd Ed. New York: Springer-Verlag, Inc, 2004:57-65.
12. DeMay RM. The Pap Smear. In: The Art and Science of Cytopathology. Chicago: ASCP Press, 1996:120-9.
13. Cangiarella JF, Chhieng DC. Atypical glandular cells - an update. Diagn Cytopathol 2003;29:271-9.
14. Covell JL, Wilbur DC, Guidos B, Lee KR, Chhieng DC, Mody DR. Epithelial abnormalities: glandular. In: Solomon D, Nayar Reds. The Bethesda System for Reporting Cervical Cytology, 2nd Ed. New York: Springer-Verlag, Inc, 2004:123-155.
15. Raab SS, Snider TE, Potts SA, McDaniel HL, Robinson RA, Nelson DL, et al. Atypical glandular cells of undetermined significance: diagnostic accuracy and interobserver variability using select cytologic criteria. Am J Clin Pathol 1997;107:299-307.
16. Simsir A, Hwang S, Cangiarella J, Elgert P, Levine P, Sheffield MV, et al. Glandular cells atypical atypical on Papanicoloau smears: interobserver variabilitiy in the diagnosis and prediction of the cell of origin. Cancer (Cancer Cytopathol) 2003;99:323-30.
17. Salom!o DR, Hughes JH, Raab SS. Atypical glandular cells of undetermined significance favor endometrial origin: criteria for separating low grade endometrial adenocarcinoma from benign endometrial lesions. Acta Cytol 2002;46:458-64.
18. DuBeshter B, Warshal DP, Angel C, Dvoretsky PM, Lin JY, Raubertas RF. Endometrial carcinoma: the relevance of cervical cytology. Obstet Gynecol 1991;77:458-62.
19. Eddy GL, Wojtowycz MA, Priaino PS, Mazur MT. Papanicoaou smears by the Bethesda System in endometrial malignancy: utility and prognostic importance. Obstet Gynecol 1997;90:999-1003.
20. Blumenfeld W, Holly EA, Mansur DL, King EB. Histiocytes and the detection of endometrial adenocarcinoma. 29:317-22.
21. Zucker PK, Kasdon EJ, Feldstein ML. The validity of pap smear parameters as predictors of endometrial pathology in menopausal women. Cancer 1985;56:2256-63.
22. Nguyen TN, Bourdeau J, Ferenczy A, Franco EL. Clinical significance of histiocytes in the detection detection of endometrial adenocarcinoma and hyperplasia. Diagn Cytopathol 1998;19:89-93.
23. Tambouret R, Bell DA, Centeno BA. Significance of histiocytes in cervical smear from postmenopausal wwomen. Diagn Cytopathol 2001;24:271-5.
24. Nassar A, Fleisher SR, Nasuti JF. Value of histiocyte detection in pap smears for predicting endometrial pathology. An institutional experience. Acta Cytol 2003;47:762-7.
25. Wen P, Abramovich CM, Wang N, Knop N, Mansbacher S, Abdul-Karim FW. Significance of histiocytes on otherwise-normal cervical smears from postmenopausal women...A retrospective study of 108 cases. A retrospective study of 108 cases. Acta Cytol 2003;47:135-40.
26. Silver SA, Sherman ME. Morphologic and immunophenotypic characterization of foam cells in endometrial lesions. Int J Gynecol Pathol 1998;17:140-5.
27. Liu W, Barrow MJ, Spitzer MF, Kochis AF. Normal exfoliation of endometrial cells in premenopausal women. Acta Cytolo 1963;11:211-4.
28. de Peralta-Venturino MN, Purslow MJ, Kini SR. Endometrial cells of the "Lower Uterine Segment" (LUS) in cervical smears obtained by endocervical brushings: a source of potential diagnostic pitfall. Diagnostic Cytopathol 1995;12:263-8.
29. Ng AB, Reagan JW, Hawliczek S, Wentz BW. Significance of endometrial cells in the detection of endometrial carcinoma and its precursors. 1974 Acta Cytol 1974;18:356-61.
30. Ng AB, Reagan JW, Cechner RL. The precursors of endometrial cancer: a study of their cellular manifestations. Acta Cytol 1973;17:437-48.
31. Demirkiran F, Arvas M, Erkun E, Kosebay D, Isiloglu H, Aktas E, et al. The prognostic significance of cervico-vaginal cytology in endometrial cancer. Eur J Gynaec Oncol 1995;16:403-9.
32. Gu M, Shi W, Barakat R, Thaler HT, Saigo PE. Pap smears in women with endometrial carcinoma. Acta Cytol 2001;45:555-60.
33. Chang A, Sandweiss L, Rose S. Cytologically benign endometrial cells in the Papanicoulaou smears of postmenopausal women. Gynecol Oncol 2001;80:37-43.
34. Gomez-Fernandez CR, Ganjei-Azar P, Behshid K, Averette HE, Nadji M. Normal endometrial cells in Papanicoulaou smears: prevalence in women with and without endometrial disease. Obstet Gynecol 2000;96:874-8.
35. Yancey M, Magelssen D, Demaurez A, Lee RB. Classification of endometrial cells on cervical cytology. Obstet Gynecol 1990;76:1000-5.
36. Gondos B, King E. Significance of endometrial cells in cervico-vaginal smears. Annals of clinical and Lab Science 1977;7:486-90.
37. Sarode VR, Rader AE, Rose PG, Rodriguez M, Abdul-Karim FW. Significance of cytologically normal endometrial cells in cervical smears from postmenopausal women. Acta Cytologica 2001;45:153-6.
38. Wu HH, Schuetz MJ, Cramer H. Significance of benign endometrial cells in Pap smears from postmenopausal women. J Repro Med 2001;46:795-8.
39. Montz FJ. Significance of "normal" endometrial cells in cervical cytology from asymptomatic postmenopausal women receiving hormone replacement therapy. Gynecol Oncol 2001;81:33-9.
40. Brogi E, Tambouret R, Bell DA. Classification of benign endometrial glandular cells in cervical smears from postmenopausal women. Cancer Cytopathol 2002;96:60-6.
41. Simsir A, Carter W, Elgert P, Cangiarella J. Reporting endometrial cells in women 40 years and older-Assessing the clinical usefulness of Bethesda 2001. Am J Clin Pathol 2005;123:571-5.
42. Gomez_Fernandez CR, Ganjei_Azar P, Capote-Sishaw J, Averette HE, Nadji M. Reporting normal endometrial cells in Pap smears: an outcome appraisal. Gynecol Oncol 1999;74:381-4.
43. Karim BO, Burroughs FH, Rosenthal DL, Ali SZ. Endometrial-type cells in cervico-vaginal smears: clinical significance and cytopathologic correlates. Diagn Cytopathol 2002;26:123-7.
44. Ely KA, Bregman S, Arnott CK. Clinical Significance of reporting endometrial cells in patients over the age of 40 and its influence on the decision to biopsy (abstract). Acta Cytol 2004;48:678.
45. Long KD, Biscotti C. An analysis of the Bethesda System 2001 guideline for reporting benign endometrial cells (abstract). Acta Cytol 2004;48:676-7.
46. Papillo JC, Harmon ML, Mount SL, Copley-Woods N. Reporting of endometrial cells in women 40Y50 results in increased endometrial biopsies with low yield (abstract). Acta Cytol 2004;48:677-8.
47. Cherkis RC, Patten S, Dickinson JC, Dekanich AS. Significance of atypical endometrial cells detected by cervical cytology. Obstet Gynecol 1987;69:786-9.
48. Van den Bosch T, Vandendael A, Wranz PA, Lombard CJ. Cervical cytology in menopausal women at high risk for endometrial disease. Eur J Cancer Prev 1998;7:149-52.
49. Cai N, Spitzer M, Wasserman PG. Endometrial cells in Pap smears of postmenopausal women: cytohistologic correlation. J Lower Gen Tract Dis 2003;7:250-3.
50. Ashfaq R, Sharma S, Dulley T, Saboorian MH, Siddiqui MT, Warner C. Clinical relevance of benign endometrial cells in postmenopausal women. Diagn Cytopathol 2001;25:235-8.
51. Kaptain S, Bloom LI, Weir MM. Hormonal effects of depo_povera in cervical smears A comparison with triphasil and postmenopausal effects. Cancer (Cancer Cytopathol) 2002;96:74-82.
52. Risse EJ, Beerthuizen RJ, Vooijs GP. Cytologic and histologic findings in women using IUD. Obstet Gynecol 1981;58:569-73.
53. Abadi MA, Barakat RR, Saigo PE. Effects of tamoxifen on cervicovaginal smears from patients with breast cancer. Acta Cytol 2000;44:141-6.
54. Dijkhuizen FP, Mol BW, Brolmann HA, Heintz AP. The accuracy of endometrial sampling in the diagnosis of patients with endometrial carcinoma and hyperplasia A meta_analysis. Cancer 2000;15:1765-72.
55. Stovall TG, Photopulos GJ, Poston WM, Ling FW, Sandles LG. Pipelle endometrial sampling in patients with known endometrial carcinoma. Obstet Gynecol 1991;77:954-6.
56. Ben BG, Seidman DS, Schiff E, Moran O, Menczer J. Outpatient endometrial sampling with the pipelle curette. Gynecol Obstet Invest 1994;37:260-2.
57. Batool T, Reginald PW, Hughes JH. Outpatient pipelle endometrial biopsy in the investigation of postmenopausal bleeding. Br J Obstet Gynaecol 1994;101:545-6.
58. Karlsson B, Granberg S, Wikland M, Ylostalo P, Torvid K, Marsal K, et al.Transvaginal ultrasonography of the endometrium in women with postmenopausal bleeding A Nordic multicenter study. Am J Obstet Gynecol 1995;172:1488-93.
59. Smith-Bindman R, Kerlikowske K, Feldstein VA, Subak L, Scheidler J, Segal M, et al. Endovaginal ultrasound to exclude endometrial cancer and other endometrial abnormalities. JAMA 1998;280:1510-7.
60. Lotfallah H, Farag K, Hassan I, Watson R. One_stop hysteroscopy clinic for postmenopausal bleeding. J Repro Med 2005;50:101-6.
61. Ferrazzi E, Torri V, Trio D, Zannoni E, Filiberto S, Dordoni D, et al. Sonographic endometrial thickness: a useful test to predict atrophy in patients with postmenopausal bleeding. An Italian multicenter study. Ultrasound Obstet Gynecol 1996;7:315-21.
62. Gambacciani M, Monteleone P, Ciaponi M, Sacco A, Genazzani AR. Clinical Usefulness of endometrial screening by ultrasound in asymptomatic postmenopausal women. Maturitas 2004;48:421-4.
63. Fleischer AC, Wheeler JE, Lindsay I, Hendrix SL, Grabill S, Kravitz B, et al. An assessment of the value of ultrasonographic screening for endometrial disease in postmenopausal women without symptoms. Am J Obstet Gynecol 2001;184:70-4.
64. Gerber B, Krause A, Muller H, Reimer T, Kulz T, Kundt G, et al. Ultrasonographic detection of asymptomatic endometrial cancer in postmenopausal patients offers no prognostic advantage over symptomatic disease discovered by uterine bleeding. Eur J Cancer 2001;37:64-71.
65. Langer RD, Pierce JJ, O'Hanlan K, Johnson SR, Espeland MA, Trabal JF, et al. Transvaginal ultrasonography compared with endometrial biopsy for the detection of endometrial disease. NEJM 1997;337:1792-8.
66. Kurman RJ, Solomon D. The Bethesda System for Reporting Cervical/Vaginal Cytologic Diagnoses: Definitions, Criteria, and Explanatory Notes for Terminology and Specimen Adequacy. New York: Springer-Verlag, 1994.
67. Fadare O, Ghofrani M, Chacho MS, Parkash V. The significance of benign endometrial cells in cervicovaginal smears. Adv Anat Pathol 2005;12:274-87.