Synthesis of 3H-spiro[benzofuran-2,1′-cyclohexane] derivatives from naturally occurring filifolinol and their classical complement pathway inhibitory activity

Bioorganic and Medicinal Chemistry Letters

Volumn 16, Issue 19, 2006, Pages 5097-5101

  Useglio, Mariana ^a   Castellano, Patricia M ^b   Operto, María A ^b   Torres, René ^c   Kaufman, Teodoro S ^a,b  

^a Universidad Nacional de Rosario   (Argentina)

^b UNIVERSIDAD NACIONAL DE ROSARIO   (Argentina)

^c UNIVERSIDAD DE SANTIAGO DE CHILE   (Chile)

Author keywords

3H spiro benzofuran 2,1 cyclohexanes ; Analogs of K76; Complement inhibition; Filifolinol

Indexed keywords

BENZOFURAN DERIVATIVE; COMPLEMENT INHIBITOR; FILIFOLINOL DERIVATIVE; UNCLASSIFIED DRUG;

ARTICLE; COMPLEMENT CLASSICAL PATHWAY; DRUG POTENCY; DRUG STRUCTURE; DRUG SYNTHESIS; HYDROLYSIS; IC 50; OXIDATION;

ANIMALS; BENZOFURANS; COMPLEMENT PATHWAY, CLASSICAL; CYCLOHEXANES; HEMOLYSIS; HETEROCYCLIC COMPOUNDS, 3-RING; HUMANS; INHIBITORY CONCENTRATION 50; PLANT EXTRACTS; SESQUITERPENES; SHEEP; SPIRO COMPOUNDS; STRUCTURE-ACTIVITY RELATIONSHIP; TRITIUM;

EID: 33747466068     PISSN: 0960894X     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.bmcl.2006.07.029     Document Type: Article

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