Dementia associates with undermedication of cardiovascular diseases in the elderly: A population-based study

Dementia and Geriatric Cognitive Disorders

Volumn 22, Issue 2, 2006, Pages 132-141

  Löppönen, Minna ^a,c   Räihä, Ismo ^a,b   Isoaho, Raimo ^a,d   Vahlberg, Tero ^a   Puolijoki, Hannu ^f   Kivelä, Sirkka Liisa ^a,b,e  

^a UNIVERSITY OF TURKU   (Finland)

^b TURKU UNIVERSITY HOSPITAL   (Finland)

^c Harkatie Health Centre   (Finland)

^d Pori Health Centre   (Finland)

^e SATAKUNTA CENTRAL HOSPITAL   (Finland)

^f SEINÄJOKI CENTRAL HOSPITAL   (Finland)

Author keywords

Dementia co morbidity; Hypertension; Stroke

Indexed keywords

ANGIOTENSIN 2 RECEPTOR ANTAGONIST; ANTIARRHYTHMIC AGENT; ANTICOAGULANT AGENT; ANTIDEPRESSANT AGENT; ANTIGLAUCOMA AGENT; ANTIGOUT AGENT; ANTIHYPERTENSIVE AGENT; ANTILIPEMIC AGENT; ANTIPYRETIC ANALGESIC AGENT; ANXIOLYTIC AGENT; BETA ADRENERGIC RECEPTOR BLOCKING AGENT; CALCIUM ANTAGONIST; CALCIUM CHANNEL BLOCKING AGENT; CARDIAC GLYCOSIDE; CARDIOVASCULAR AGENT; DIPEPTIDYL CARBOXYPEPTIDASE INHIBITOR; DIURETIC AGENT; HYPNOTIC SEDATIVE AGENT; LAXATIVE; LOOP DIURETIC AGENT; NEUROLEPTIC AGENT; NITRIC ACID DERIVATIVE; NONSTEROID ANTIINFLAMMATORY AGENT; ORAL ANTIDIABETIC AGENT; POTASSIUM SPARING DIURETIC AGENT; SULFONAMIDE; THYROXINE; TRIMETHOPRIM; UNINDEXED DRUG; VASODILATOR AGENT;

AGED; ARTICLE; CARDIOVASCULAR DISEASE; CONGESTIVE HEART FAILURE; CONTROLLED STUDY; DEMENTIA; DISEASE SEVERITY; FEMALE; FINLAND; HEART ATRIUM FIBRILLATION; HUMAN; HYPERCHOLESTEROLEMIA; HYPERTENSION; ISCHEMIC HEART DISEASE; MAJOR CLINICAL STUDY; MALE; MULTIVARIATE ANALYSIS; PRESCRIPTION; PRIORITY JOURNAL; QUANTITATIVE ANALYSIS; SELF REPORT; STANDARDIZATION; STROKE;

AGED; CARDIOVASCULAR AGENTS; CARDIOVASCULAR DISEASES; DEMENTIA; ELECTROCARDIOGRAPHY; FEMALE; FINLAND; HUMANS; LONGITUDINAL STUDIES; MALE; NEUROPSYCHOLOGICAL TESTS; PATIENT COMPLIANCE; POPULATION; RISK ASSESSMENT;

EID: 33747444276     PISSN: 14208008     EISSN: None     Source Type: Journal    
DOI: 10.1159/000093739     Document Type: Article

References (44)

1. Klarin I, Fastbom J, Wimo A: A population-based study of drug use in the very old living in a rural district of Sweden, with focus on cardiovascular drug consumption: comparison with an urban cohort. Pharmacoepidemiol Drug Saf 2003;12:669-678.
2. Strandberg TE, Pitkala K, Kulp S, Tilvis RS: Use of cardiovascular drugs by home-dwelling coronary patients aged 75 years and older: a population-based cross-sectional survey in Helsinki, Finland. Eur J Clin Pharmacol 2001;57:513-516.
3. Rodriguez EG, Dodge HH, Birzescu MA, Stoehr GP, Ganguli M: Use of lipid-lowering drugs in older adults with and without dementia: a community-based epidemiological study. J Am Geriatr Soc 2002;50:1852-1856.
4. Ho SF, O'Mahony MS, Steward JA, Burr ML, Buchalter M: Left ventricular systolic dysfunction and atrial fibrillation in older people in the community - A need for screening? Age Ageing 2004;33:488-492.
5. Rockwood K, Ebly E, Hachinski V, Hogan D: Presence and treatment of vascular risk factors in patients with vascular cognitive impairment. Arch Neurol 1997;54:33-39.
6. Gambassi G, Forman DE, Lapane KL, Mor V, Sgadari A, Lipsitz LA, Bernabei R: Management of heart failure among very old persons living in long-term care: has the voice of trials spread? The SAGE Study Group. Am Heart J 2000;139:85-93.
7. Sloane PD, Gruber-Baldini AL, Zimmerman S, Roth M, Watson L, Boustani M, Magaziner J, Hebel JR: Medication undertreatment in assisted living settings. Arch Intern Med 2004;164:2031-2037.
8. Moroney JT, Tseng CL, Paik MC, Mohr JP, Desmond DW: Treatment for the secondary prevention of stroke in older patients: the influence of dementia status. J Am Geriatr Soc 1999;47:824-829.
9. Richards SS, Emsley CL, Roberts J, Murray MD, Hall K, Gao S, Hendrie HC: The association between vascular risk factor-mediating medications and cognition and dementia diagnosis in a community-based sample of African-Americans. J Am Geriatr Soc 2000; 48:1035-1041.
10. Breteler MM: Vascular risk factors for Alzheimer's disease: an epidemiologic perspective. Neurobiol Aging 2000;21:153-160.
11. Newman AB, Fitzpatrick AL, Lopez O, Jackson S, Lyketsos C, Jagust W, Ives D, Dekosky ST, Kuller LH: Dementia and Alzheimer's disease incidence in relationship to cardiovascular disease in the Cardiovascular Health Study cohort. J Am Geriatr Soc 2005; 53:1101-1107.
12. de la Torre JC: Alzheimer disease as a vascular disorder: nosological evidence. Stroke 2002;33:1152-1162.
13. Roman GC: Vascular dementia: distinguishing characteristics, treatment, and prevention. J Am Geriatr Soc 2003;51(suppl 5): S296-304.
14. Linjakumpu T, Hartikainen S, Klaukka T, Veijola J, Kivela SL, Isoaho R: Use of medications and polypharmacy are increasing among the elderly. J Clin Epidemiol 2002;55: 809-817.
15. Lopponen M, Raiha II, Isoaho R, Vahlberg T, Kivela SL: Diagnosing cognitive impairment and dementia in primary health care - A more active approach is needed. Age Ageing 2003;32:606-612.
16. Lopponen MK, Isoaho RE, Raiha IJ, Vahlberg TJ, Loikas SM, Takala TI, Puolijoki H, Irjala K, Kivela S-L: Undiagnosed diseases in patients with dementia - A potential target group for intervention. Dement Geriatr Cogn Disord 2004;18:321-329.
17. National Agency of Medicines: Classification of Medicines (ATC) and Defined Daily Doses (DDD) 2000. Helsinki, National Agency of Medicines, 2000.
18. Rose GABH, Gillum RF, Prineas RJ: Cardiovascular Survey Methods, ed 2. Geneva, World Health Organisation, 1982.
19. World Health Organization: Tautiluokitus ICD-10 (Classification of Diseases ICD-10). Rauma, Kirjapaino Oy West Point, 1995.
20. Hachinski VC, Iliff LD, Zilhka E, Du Boulay GH, McAllister VL, Marshall J, Russell RW, Symon L: Cerebral blood flow in dementia. Arch Neurol 1975;32:632-637.
21. Hughes CP, Berg L, Danziger WL, Coben LA, Martin RL: A new clinical scale for the staging of dementia. Br J Psychiatry 1982; 140:566-572.
22. American Psychiatric Association, Finnish Psychiatric Association: DSM-IV diagnostiset kriteerit (DSM-IV diagnostic criteria). Finnreklama, Orion-yhtymä Oy, 1997.
23. McKhann G, Drachman D, Folstein M, Katzman R, Price D, Stadlan EM: Clinical diagnosis of Alzheimer's disease: Report of the NINCDS-ADRDA Work Group under the auspices of Department of Health and Human Services Task Force on Alzheimer's Disease. Neurology 1984;34:939-944.
24. Roman GC, Tatemichi TK, Erkinjuntti T, Cummings JL, Masdeu JC, Garcia JH, Amaducci L, Orgogozo J-M, Brun A, Hofman A, Moody DM, O'Brien MD, Yamaguchi T, Grafman J, Drayes BP, Bennet DA, Fisher M, Ogata J, Kokmen E, Bermejo F, Wolf PA, Gorelick PB, Bick KL, Pajeau AK, Bell MA, DeCarli C, Culebras A, Korczyn AD, Bougousslavsky J, Hartaman A, Scheinberg P: Vascular dementia: diagnostic criteria for research studies. Report of the NINDS-AIREN International Workshop. Neurology 1993; 43:250-260.
25. Juva K, Sulkava R, Erkinjuntti T, Ylikoski R, Valvanne J, Tilvis R: Usefulness of the Clinical Dementia Rating scale in screening for dementia. Int Psychogeriatr 1995;7:17-24.
26. Remes J, Miettinen H, Reunanen A, Pyorala K: Validity of clinical diagnosis of heart failure in primary health care. Eur Heart J 1991; 12:315-321.
27. Ahto M, Isoaho R, Puolijoki H, Laippala P, Romo M, Kivela SL: Prevalence of coronary heart disease, associated manifestations and electrocardiographic findings in elderly Finns. Age Ageing 1998;27:729-737.
28. Appelros P, Nydevik I, Viitanen M: Poor outcome after first-ever stroke: predictors for death, dependency, and recurrent stroke within the first year. Stroke 2003;34:122-126.
29. Appelros P, Nydevik I, Seiger A, Terent A: Predictors of severe stroke: influence of preexisting dementia and cardiac disorders. Stroke 2002;33:2357-2362.
30. Albers GW, Amarenco P, Easton JD, Sacco RL, Teal P: Antithrombotic and thrombolytic therapy for ischemic stroke. Chest 2001; 119(suppl 1):300S-320S.
31. Bugiani O: A beta-related cerebral amyloid angiopathy. Neurol Sci 2004;25(suppl 1):S1-2.
32. Castellani RJ, Smith MA, Perry G, Friedland RP: Cerebral amyloid angiopathy: major contributor or decorative response to Alzheimer's disease pathogenesis. Neurobiol Aging 2004;25:599-602, discussion 603-4.
33. Doherty DL: Posttraumatic cerebral atrophy as a risk factor for delayed acute subdural hemorrhage. Arch Phys Med Rehabil 1988; 69:542-544.
34. Horimoto Y, Matsumoto M, Akatsu H, Ikari H, Kojima K, Yamamoto T, Otsuka Y, Ojika K, Ueda R, Kosaka K: Autonomic dysfunctions in dementia with Lewy bodies. J Neurol 2003;250:530-533.
35. Guidelines for the evaluation and management of heart failure: report of the American College of Cardiology/American Heart Association Task Force on Practice Guidelines (Committee on Evaluation and Management of Heart Failure). Circulation 1995;92:2764-2784.
36. Rochon PA, Gurwitz JH: Prescribing for seniors: neither too much nor too little. JAMA 1999;282:113-115.
37. Fialova D, Topinkova E, Gambassi G, Finne-Soveri H, Jonsson PV, Carpenter I, Schroll M, Onder G, Sorby LW, Wagner C, Reissigova J, Bernabei R: Potentially inappropriate medication use among elderly home care patients in Europe. JAMA 2005;293:1348-1358.
38. Piguet O, Grayson DA, Creasey H, Bennett HP, Brooks WS, Waite LM, Broe GA: Vascular risk factors, cognition and dementia incidence over 6 years in the Sydney Older Persons Study. Neuroepidemiology 2003;22: 165-171.
39. Birkenhager WH, Forette F, Staessen JA: Dementia and antihypertensive treatment. Curr Opin Nephrol Hypertens 2004;13:225-230.
40. Rea TD, Breitner JC, Psaty BM, Fitzpatrick AL, Lopez OL, Newman AB, Hazzard WR, Zandi PP, Burke GL, Lyketsos CG, Bernick C, Kuller LH: Statin use and the risk of incident dementia: the Cardiovascular Health Study. Arch Neurol 2005;62:1047-1051.
41. Ruitenberg A, Skoog I, Ott A, Aevarsson O, Witteman JC, Lernfelt B, van Harkamp F, Hofman A, Breteler MM: Blood pressure and risk of dementia: Results from the Rotterdam study and the Gothenburg H-70 Study. Dement Geriatr Cogn Disord 2001;12:33-39.
42. Strandberg TE, Pitkala K, Berglind S, Nieminen MS, Tilvis RS: Possibilities of multifactorial cardiovascular disease prevention in patients aged 75 and older: a randomized controlled trial. Drugs and Evidence-Based Medicine in the Elderly (DEBATE) Study. Eur Heart J 2003;24:1216-1222.
43. Strandberg TE, Pitkala K, Berglind S, Nieminen MS, Tilvis RS: Multifactorial cardiovascular disease prevention in patients aged 75 years and older: a randomized controlled trial. Drugs and Evidence-Based Medicine in the Elderly (DEBATE) Study. Am Heart J 2001;142:945-951.
44. Moore AR, O'Keeffe ST: Drug-induced cognitive impairment in the elderly. Drugs Aging 1999;15:15-28.