The influence of PVP incorporation on moisture-induced surface crystallization of amorphous spray-dried lactose particles

International Journal of Pharmaceutics

Volumn 321, Issue 1-2, 2006, Pages 78-85

  Mahlin, Denny ^a   Berggren, Jonas ^a   Gelius, Ulrik ^a   Engström, Sven ^b   Alderborn, Göran ^a  

^a UPPSALA UNIVERSITY   (Sweden)

^b CHALMERS UNIVERSITY OF TECHNOLOGY   (Sweden)

Author keywords

Atomic force microscopy; Crystallization; Electron spectroscopy for chemical analysis; Lactose; Rate constant; Spray dried particles

Indexed keywords

LACTOSE; POVIDONE;

ARTICLE; ATOMIC FORCE MICROSCOPY; CHEMICAL ANALYSIS; CRYSTALLIZATION; HUMIDITY; MOISTURE; MOLECULAR WEIGHT; PRIORITY JOURNAL; SPECTROSCOPY; SPRAY DRYING;

CRYSTALLIZATION; HUMIDITY; LACTOSE; MICROSCOPY, ATOMIC FORCE; POLYVINYLS; PYRROLIDINES; TECHNOLOGY, PHARMACEUTICAL;

EID: 33747361036     PISSN: 03785173     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.ijpharm.2006.05.016     Document Type: Article

References (28)

1. Aso Y., Yoshioka S., and Kojima S. Molecular mobility-based estimation of the crystallization rates of amorphous nifedipine and phenobarbital in poly(vinylpyrrolidone) solid dispersions. J. Pharm. Sci. 93 (2004) 384-391
2. Avrami M. Kinetics of phase change. II. Transformation-time relations for random distribution of nuclei. J. Chem. Phys. 8 (1940) 212-224
3. Berggren J., and Alderborn G. Effect of polymer content and molecular weight on the morphology and heat- and moisture-induced transformations of spray-dried composite particles of amorphous lactose and poly(vinylpyrrolidone). Pharm. Res. 20 (2003) 1039-1046
4. Briggner L.E., Buckton G., Byström K., and Darcy P. The use of isothermal microcalorimetry in the study of changes in crystallinity induced during the processing of powders. Int. J. Pharm. 105 (1994) 125-135
5. Crowley K.J., and Zografi G. The effect of low concentrations of molecularly dispersed poly(vinylpyrrolidone) on indomethacin crystallization from the amorphous state. Pharm. Res. 20 (2003) 1417-1422
6. Elversson J., and Millqvist-Fureby A. Aqueous two-phase systems as a formulation concept for spray-dried protein. Int. J. Pharm. 294 (2005) 73-87
7. Elversson J., Millqvist-Fureby A., Alderborn G., and Elofsson U. Droplet and particle size relationship and shell thickness of inhalable lactose particles during spray drying. J. Pharm. Sci. 92 (2003) 900-910
8. Gelius U., Wannberg B., Baltzer P., Fellnerfeldegg H., Carlsson G., Johansson C.G., Larsson J., Munger P., and Vegerfors G. A new ESCA instrument with improved surface sensitivity, fast imaging properties and excellent energy resolution. J. Electron Spectrosc. Relat. Phenom. 52 (1990) 747-785
9. Hancock B.C., and Zografi G. The relationship between the glass-transition temperature and the water-content of amorphous pharmaceutical solids. Pharm. Res. 11 (1994) 471-477
10. Huang Q.R., and Wang C.H. Surface laser light scattering studies of the air/poly(N-vinyl-2-pyrrolidone)-water solution interface. J. Chem. Phys. 105 (1996) 6546-6552
11. Hüttenrauch R. Molekulargalenik ais Grundlage modemer Arzneiformung. Acta Pharm. Tech. 6 (1978) 55-127
12. Jouppila K., Kansikas J., and Roos Y.H. Crystallization and X-ray diffraction of crystals formed in water-plasticized amorphous lactose. Biotechnol. Prog. 14 (1998) 347-350
13. Lai M., and Topp E. Solid-state chemical stability of proteins and peptides. J. Pharm. Sci. 88 (1999) 489-500
14. Lechuga-Ballesteros D., Bakri A., and Miller D.P. Microcalorimetric measurement of the interactions between water vapor and amorphous pharmaceutical solids. Pharm. Res. 20 (2003) 308-318
15. Lehto V.P., and Laine E. Simultaneous determination of the heat and the quantity of vapor sorption using a novel microcalorimetric method. Pharm. Res. 17 (2000) 701-706
16. Mahlin D., Berggren J., Alderborn G., and Engström S. Moisture-induced surface crystallization of spray-dried amorphous lactose particles studied by atomic force microscopy. J. Pharm. Sci. 93 (2004) 29-37
17. Matsumoto T., and Zografi G. Physical properties of solid molecular dispersions of indomethacin with poly(vinylpyrrolidone) and poly(vinylpyrrolidone-co-vinylacetate) in relation to indomethacin crystallization. Pharm. Res. 16 (1999) 1722-1728
18. Miao S., and Roos Y.H. Crystallization kinetics and X-ray diffraction of crystals formed in amorphous lactose, trehalose, and lactose/trehalose mixtures. J. Food. Sci. 70 (2005) E350-E358
19. Pikal M.J., Dellerman K.M., Roy M.L., and Riggin R.M. The effects of formulation variables on the stability of freeze-dried human growth-hormone. Pharm. Res. 8 (1991) 427-436
20. Price R., and Young P.M. Visualization of the crystallization of lactose from the amorphous state. J. Pharm. Sci. 93 (2004) 155-164
21. Schmitt E.A., Law D., and Zhang G.G.Z. Nucleation and crystallization kinetics of hydrated amorphous lactose above the glass transition temperature. J. Pharm. Sci. 88 (1999) 291-296
22. Sebhatu T., Angberg M., and Ahlneck C. Assessment of the degree of disorder in crystalline solids by isothermal microcalorimetry. Int. J. Pharm. 104 (1994) 135-144
23. Shamblin S.L., Huang E.Y., and Zografi G. The effects of co-lyophilized polymeric additives on the glass transition temperature and crystallization of amorphous sucrose. J. Therm. Anal. 47 (1996) 1567-1579
24. Stubberud L., and Forbes R.T. The use of gravimetry for the study of the effect of additives on the moisture-induced recrystallisation of amorphous lactose. Int. J. Pharm. 163 (1998) 145-156
25. Takeuchi H., Yasuji T., Yamamoto H., and Kawashima Y. Temperature-induced crystallization and compactibility of spray dried composite particles composed of amorphous lactose and various types of water-soluble polymer. Chem. Pharm. Bull. 48 (2000) 585-588
26. Zhang G.G.Z., Law D., Schmitt E.A., and Qiu Y.H. Phase transformation considerations during process development and manufacture of solid oral dosage forms. Adv. Drug Deliv. Rev. 56 (2004) 371-390
27. Zhang J., and Zografi G. Water vapor absorption into amorphous sucrose-poly(vinyl pyrrolidone) and trehalose-poly(vinyl pyrrolidone) mixtures. J. Pharm. Sci. 90 (2001) 1375-1385
28. Zhou D.L., Schmitt E.A., Zhang G.G., Law D., Vyazovkin S., Wight C.A., and Grant D.J.W. Crystallization kinetics of amorphous nifedipine studied by model-fitting and model-free approaches. J. Pharm. Sci. 92 (2003) 1779-1792