Effectiveness of commercially-available antibiotic-impregnated implants

Journal of Bone and Joint Surgery - Series B

Volumn 88, Issue 8, 2006, Pages 1102-1104

  Wenke, Joseph C ^a   Owens, B D ^a   Svoboda, S J ^a   Brooks, D E ^a  

^a US ARMY INSTITUTE OF SURGICAL RESEARCH   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ANTIBIOTIC AGENT; CALCIUM SULFATE; POLY(METHYL METHACRYLATE); STREPTOMYCIN; TOBRAMYCIN SULFATE;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ANTIBIOTIC RESISTANCE; ARTICLE; BIODEGRADABLE IMPLANT; BONE INFECTION; COAGULASE NEGATIVE STAPHYLOCOCCUS; CONTROLLED STUDY; DISEASE MODEL; GOAT; INOCULATION; MALE; NONHUMAN; OPEN FRACTURE; PRIORITY JOURNAL; STAPHYLOCOCCUS AUREUS; TISSUE CULTURE; TREATMENT OUTCOME;

ANIMALS; ANTI-BACTERIAL AGENTS; BONE DISEASES, INFECTIOUS; CALCIUM SULFATE; COLONY COUNT, MICROBIAL; DISEASE MODELS, ANIMAL; DRUG IMPLANTS; FRACTURES, BONE; GOATS; MALE; MICROSPHERES; POLYMETHYL METHACRYLATE; STAPHYLOCOCCUS AUREUS; TOBRAMYCIN; TREATMENT OUTCOME;

EID: 33747357185     PISSN: 0301620X     EISSN: None     Source Type: Journal    
DOI: 10.1302/0301-620X.88B8.17368     Document Type: Article

References (14)

1. Beardmore AA, Brooks DE, Wenke JC, Thomas DB. Effectiveness of local antibiotic delivery with an osteoinductive and osteoconductive bone-graft substitute. J Bone Joint Surg [Am] 2005;87-A:107-12.
2. Thomas DB, Brooks DE, Bice TG, et al. Tobramycin-impregnated calcium sulfate prevents infection in contaminated wounds. Clin Orthop 2005;441:366-71.
3. Buchholz HW, Elson RA, Heinert K. Antibiotic-loaded acrylic cement: current concepts. Clin Orthop 1984;190:96-108.
4. Ostermann PA, Seligson D, Henry SL. Local antibiotic therapy for severe open fractures: a review of 1085 consecutive cases. J Bone Joint Surg [Br] 1995;77-B:93-7.
5. Kelly CM, Wilkins RM, Gitelis S, et al. Use of a surgical grade calcium sulfate as a bone graft substitute: results of a multicenter trial. Clin Orthop 2001;382:42-50.
6. Mirzayan R, Panossian V, Avedian R, Forrester DM, Menendez LR. The use of calcium sulfate in the treatment of benign bone lesions: a preliminary report. J Bone Joint Surg [Am] 2001;83-A:355-8.
7. Turner TM, Urban RM, Hall DJ, et al. Local and systemic levels of tobramycin delivered from calcium sulfate bone graft substitute pellets. Clin Orthop 2005;437: 97-104.
8. DeJong ES, DeBarrardino TM, Brooks DE, et al. Antimicrobial efficacy of external fixator pins coated with a lipid stabilized hydroxyapatite-chlorhexidine complex to prevent pin tract infection in a goat model. J Trauma 2001;50:1008-14.
9. Adams K, Couch L, Cierny G, Calhoun J, Mader JT. In vivo and in vitro evaluation of antibiotic diffusion from antibiotic-impregnated polymethylmethacrylate beads. Clin Orthop 1992;278:244-52.
10. Scott CP, Higham PA, Dumbleton JH. Effectiveness of bone cement containing tobramycin: an in vitro susceptibility study of 99 organisms found in infected joint arthroplasty. J Bone Joint Surg [Br] 1999;81-B:440-3.
11. Armstrong DG, Findlow AH, Oyibo SO, Boulton AJ. The use of absorbable antibiotic-impregnated calcium sulphate pellets in the management of diabetic foot infections. Diabet Med 2001;18:942-3.
12. Gitelis S, Brebach GT. The treatment of chronic osteomyelitis with a biodegradable antibiotic-impregnated implant. J Orthop Surg (Hong Kong) 2002;10:53-60.
13. McKee MD, Wild LM, Schemitsch EH, Waddell JP. The use of an antibiotic-impregnated, osteoconductive, bioabsorbable bone substitute in the treatment of infected long bone defects: early results of a prospective trial. J Orthop Trauma 2002; 16:622-7.
14. von Stechow D, Scale D, Rauschmann MA. Minimizing the surgical approach in patients with spondylitis. Clin Orthop 2005;439:61-7.