The use of genome scale metabolic flux variability analysis for process feed formulation based on an investigation of the effects of the zwf mutation on antibiotic production in Streptomyces coelicolor

Enzyme and Microbial Technology

Volumn 39, Issue 6, 2006, Pages 1347-1353

  Bushell, Michael E ^a   Sequeira, Susana I P ^a   Khannapho, Chiraphan ^a   Zhao, Hongjuan ^a   Chater, Keith F ^b   Butler, Michael J ^b   Kierzek, Andrzej M ^a   Avignone Rossa, Claudio A ^a  

^a UNIVERSITY OF SURREY   (United Kingdom)

^b JOHN INNES CENTRE   (United Kingdom)

Author keywords

Actinorhodin; Antibiotic biosynthesis; Antibiotic production; Flux variability analysis; Streptomyces; Streptomyces coelicolor

Indexed keywords

ANTIBIOTICS; BIOSYNTHESIS; CELL CULTURE; ENZYMES; GENES; REACTION KINETICS;

ACTINORHODIN; ANTIBIOTIC BIOSYNTHESIS; ANTIBIOTIC PRODUCTION; FLUX VARIABILITY ANALYSIS; FLUX VARIABILITY DISTRIBUTION; STREPTOMYCES; STREPTOMYCES COELICOLOR;

BIOTECHNOLOGY;

ACTINORHODINE; GLUCOSE 6 PHOSPHATE DEHYDROGENASE;

ARTICLE; BIOSYNTHESIS; CATABOLISM; COMPUTER MODEL; DRUG MANUFACTURE; ENZYME ACTIVITY; FOOD; GENE DELETION; GENOMICS; GROWTH; MOLECULAR INTERACTION; MUTATION; NONHUMAN; NUCLEOTIDE SEQUENCE; NUTRIENT UPTAKE; PLASMID; PREDICTION; SIMULATION; STEADY STATE; STREPTOMYCES COELICOLOR; SURVIVAL;

STREPTOMYCES COELICOLOR;

EID: 33747354689     PISSN: 01410229     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.enzmictec.2006.06.011     Document Type: Article

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