Solubility parameter of drugs for predicting the solubility profile type within a wide polarity range in solvent mixtures

International Journal of Pharmaceutics

Volumn 321, Issue 1-2, 2006, Pages 155-161

  Pena M A ^a   Reillo A ^a   Escalera, B ^a   Bustamante, P ^a  

^a UNIVERSITY OF ALCALÁ   (Spain)

Author keywords

Acetanilide; Benzocaine; Cosolvent action; Phenacetin; Salicylic acid; Solubility; Solubility parameter; Solvent mixtures

Indexed keywords

ACETANILIDE; ACETIC ACID ETHYL ESTER; ALCOHOL; BENZOCAINE; DIOXANE; PHENACETIN; SALICYLIC ACID; SOLVENT; WATER;

ARTICLE; CALCULATION; CHEMICAL PARAMETERS; DRUG SOLUBILITY; MATHEMATICAL ANALYSIS; PREDICTION; PRIORITY JOURNAL;

ACETANILIDES; BENZOCAINE; CHEMISTRY, PHARMACEUTICAL; PHARMACEUTICAL PREPARATIONS; PHENACETIN; SALICYLIC ACID; SOLUBILITY; SOLVENTS;

EID: 33747354139     PISSN: 03785173     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.ijpharm.2006.05.014     Document Type: Article

References (16)

1. Barra J., Peña M.A., and Bustamante P. Proposition of group constants for sodium to calculate the partial solubility parameters of sodium salts using the van Krevelen group contribution method. Eur. J. Pharm. Sci. 10 (2000) 153-161
2. Bustamante P., Escalera B., Martin A., and Sellés E. Predicting the solubility of sulfamethoxypyridazine in individual solvents. I. Calculating partial solubility parameters. J. Pharm. Sci. 78 (1989) 567-573
3. Bustamante P., Escalera B., Martin A., and Sellés E. A modification of the extended Hildebrand approach to predict the solubility of structurally related drugs in solvent mixtures. J. Pharm. Pharmacol. 45 (1993) 253-257
4. Bustamante P., Ochoa R., Reillo A., and Escalera J. Chameleonic effect of sulfanilamide and sulfamethazine in solvent mixtures. Solubility curves with two maxima. Chem. Pharm. Bull. 42 (1994) 1129-1133
5. Bustamante P., Navarro J., Romero S., and Escalera B. Thermodynamic origin of the solubility profile of drugs showing one or two maxima against the polarity of aqueous and non-aqueous mixtures: niflumic acid and caffeine. J. Pharm. Sci. 91 (2002) 874-883
6. Chertkoff M.J., and Martin A.N. The solubility of benzoic acid in mixed solvents. J. Am. Pharm. Assoc. Sci. 49 (1960) 444-447
7. Escalera B., Bustamante P., and Martin A. Predicting the solubility of drugs in solvent mixtures: multiple solubility maxima and the chameleonic effect. J. Pharm. Pharmacol. 46 (1994) 172-176
8. Fedors R.F. A method for estimating both the solubility parameters and molar volumes of liquids. Polym. Eng. Sci. 14 (1974) 147-154
9. Machatha S.G., and Yalkowsky S.H. Estimation of the ethanol/water solubility profile from the octanol/water partition coefficient. Int. J. Pharm. 286 (2004) 111-115
10. Machatha S.G., Bustamante P., and Yalkowsky S.H. Deviation from linearity of drug solubility in ethanol/water mixtures. Int. J. Pharm. 283 (2004) 83-88
11. Martin A., Newburger J., and Adjei A. New solubility equation. J. Pharm. Sci. 68 (1979) 4-5
12. Martin A., Paruta A.N., and Adjei A. Extended Hildebrand solubility approach: methylxanthines in mixed solvents. J. Pharm. Sci. 70 (1981) 1115-1119
13. Paruta A.N., and Irani S.A. Dielectric solubility profiles in dioxane-water mixtures for several antipyretic drugs. Effect of substituents. J. Pharm. Sci. 54 (1965) 1334-1338
14. Peña M.A., Bustamante P., Escalera B., Reíllo A., and Bosque Sendra J.M. Solubility and phase separation of benzocaine and salicylic acid in 1,4-dioxane-water mixtures at several temperatures. J. Pharm. Biomed. Anal. 36 (2004) 571-578
15. Romero S., Reillo A., Escalera B., and Bustamante P. The behavior of paracetamol in mixtures of amphiprotic and amphiprotic-aprotic solvents. Relationship of solubility curves to specific and nonspecific interactions. Chem. Pharm. Bull. 44 (1996) 1061-1064
16. Romero S., Escalera B., and Bustamante P. Solubility behaviour of polymorphs I and II of mefenamic acid in solvent mixtures. Int. J. Pharm. 178 (1999) 193-202