Drug/lactose co-micronization by jet milling to improve aerosolization properties of a powder for inhalation

International Journal of Pharmaceutics

Volumn 321, Issue 1-2, 2006, Pages 162-166

  Giry, K ^a   Pean J M ^a   Giraud, L ^a   Marsas, S ^a   Rolland, H ^a   Wuthrich P ^a  

^a INSTITUT DE RECHERCHES INTERNATIONALES SERVIER   (France)

Author keywords

Agglomerate; Co micronization; Dry powder inhaler; Jet milling; Lactose; Respirable fraction

Indexed keywords

DRUG CARRIER; FUSAFUNGINE; INHALAC; LACTOCHEM; LACTOSE; LACTOSE FAST FLO; PEARLITOL;

AEROSOL; ARTICLE; DIFFERENTIAL SCANNING CALORIMETRY; DRUG FORMULATION; DRY POWDER; INHALER; PARTICLE SIZE; PHYSICAL CHEMISTRY; PRIORITY JOURNAL; THEORETICAL STUDY;

ADMINISTRATION, INHALATION; AEROSOLS; CHEMISTRY, PHARMACEUTICAL; LACTOSE; POWDERS; TECHNOLOGY, PHARMACEUTICAL;

EID: 33747352312     PISSN: 03785173     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.ijpharm.2006.05.009     Document Type: Article

References (13)

1. Borgström L., Bisgaard H., O'Callaghan C., and Pedersen S. Dry powder inhalers. In: Bisgaard H., O'Callaghan C., and Smaldone G.C. (Eds). Drug Delivery to the Lung (2002), Dekker, New York 421-443
2. Larhib H., Martin G.P., Marriott C., and Prime D. The influence of carrier and drug morphology on drug delivery from dry powder formulations. Int. J. Pharm. 257 (2003) 283-296
3. Lewis G.A., Mathieu D., and Phan-Tan-Luu R. Pharmaceutical Experimental Design (1999), Dekker, New York
4. Lotan, N., Caponetti, G., Edwards, D., Hanes, J., Langer, R., Ben-Jenbria, A.A., Hrkach, J., 2003. Aerodynamically light particles for pulmonary drug delivery. US Patent US2003012742.
5. Louey M.D., and Stewart J.P. Particle interactions involved in aerosol dispersion of ternary interactive mixtures. Pharm. Res. 19 (2002) 1524-1531
6. Newman S.P., and Busse W.W. Evolution of dry powder inhaler design, formulation, and performance. Respir. Med. 96 (2002) 293-304
7. Rehman M., Shekunov B.Y., York P., Lechuga-Ballesteros D., Miller D.P., Tan T., and Colthorpe P. Optimisation of powders for pulmonary delivery using supercritical fluid technology. Eur. J. Pharm. Biopharm. 55 (2004) 115-124
8. Reverchon E., and Della Porta G. Terbutaline particles suitable for aerosol delivery produced by supercritical assisted atomisation. Int. J. Pharm. 258 (2003) 1-9
9. Staniforth, J., Morton, D., Tobyn, M., Eason, S., Harmer, Q., Ganderton, D., 2004. Devices and pharmaceutical compositions for enhancing dosing efficiency. WO2004093848.
10. Steckel H., Rasenack N., Villax P., and Müller B.W. In vitro characterization of jet milled and in-situ-micronized fluticasone-17-propionate. Int. J. Pharm. 258 (2003) 65-75
11. Tee S.K., Marriott C., Zeng X.M., and Martin G.P. The use of different sugars as fine and coarse carriers for aerosolized salbutamol sulfate. Int. J. Pharm. 208 (2000) 111-123
12. Zeng X.M., Martin G.P., Tee S.K., Ghoush A.A., and Marriott C. Effect of particle size and adding sequence of fine lactose on the deposition of salbutamol sulfate from dry powder formulation. Int. J. Pharm. 182 (1999) 133-144
13. Zeng X.M., Martin G.P., Marriott C., and Pritchard J. The effect of carrier size and morphology on the dispersion of salbutamol sulfate after aerosolization at different flow rates. J. Pharm. Pharmacol. 52 (2000) 1211-1221