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Poirier P, Giles TD, Bray GA, et al. American Heart Association; Obesity Committee of the Council on Nutrition, Physical Activity, and Metabolism. Obesity and cardiovascular disease: pathophysiology, evaluation, and effect of weight loss - an update of the 1997 American Heart Association Scientific Statement on Obesity and Heart Disease from the Obesity Committee of the Council on Nutrition, Physical Activity, and Metabolism. Circulation 2006; 113:898-918. This is an important summary of the evidence linking obesity to cardiovascular disease with clinical implications for both specialists and primary care physicians.
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Poirier, P.1
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Poirier P, Lemieux I, Mauriege P, et al. Impact of waist circumference on the relationship between blood pressure and insulin: the Quebec Health Survey. Hypertension 2005; 45:363-367. Elegant study demonstrating that the association between obesity and blood pressure is largely explained by concomitant variation in waist circumference.
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Mamun AA, Lawlor DA, O'Callaghan MJ, Williams GM, et al. Effect of body mass index changes between ages 5 and 14 on blood pressure at age 14: findings from a birth cohort study. Hypertension 2005; 45:1083-1087. This interesting study highlighted the important role of weight changes in the development and maintenance of hypertension in children and adolescents.
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Thomas, F.1
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Rahmouni K, Correia ML, Haynes WG, Mark AL. Obesity-associated hypertension: new insights into mechanisms. Hypertension 2005; 45:9-14. An excellent review discussing the novel mechanisms linking obesity to hypertension.
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Ahmed, S.B.1
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Pausova Z. From big fat cells to high blood pressure: a pathway to obesity-associated hypertension. Curr Opin Nephrol Hypertens 2006; 15:173-178. An excellent review discussing the consequences of accumulation of 'dysfunctional' adipose tissue characterized by the presence of 'large' adipocytes.
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Ribeiro MM, Silva AG, Santos NS, et al. Diet and exercise training restore blood pressure and vasodilatory responses during physiological maneuvers in obese children. Circulation 2005; 111:1915-1923. Obesity exacerbates blood pressure responses and impairs vasodilatory responses during exercise and mental stress in obese children; the alterations might be reversed by diet and exercise training.
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Ribeiro, M.M.1
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Zebekakis PE, Nawrot T, Thijs L, et al. Obesity is associated with increased arterial stiffness from adolescence until old age. J Hypertens 2005; 23:1839-1846. This well designed study demonstrated differential influence of adiposity on the properties of muscular and elastic arteries.
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Jandeleit-Dahm KA, Tikellis C, Reid CM, et al. Why blockade of the renin-angiotensin system reduces the incidence of new-onset diabetes. J Hypertens 2005; 23:463-473. Elegant review including meta-analysis with important implications for treatment of hypertensive people at risk of development of diabetes.
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Clasen R, Schupp M, Foryst-Ludwig A, et al. PPARgamma-activating angiotensin type-1 receptor blockers induce adiponectin. Hypertension 2005; 46:137-143. Interesting study exploring novel mechanism responsible for insulin-sensitizing/ antidiabetic effects of PPARgamma-activating angiotensin type-1 receptor blockers.
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Hypertension in overweight and obese primary care patients is highly prevalent and poorly controlled
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Bramlage P, Pittrow D, Wittchen HU, et al. Hypertension in overweight and obese primary care patients is highly prevalent and poorly controlled. Am J Hypertens 2004; 17:904-910.
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(2004)
Am J Hypertens
, vol.17
, pp. 904-910
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Bramlage, P.1
Pittrow, D.2
Wittchen, H.U.3
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