Diffuse Alveolar Hemorrhage: Retrospective Review of Clinical Outcome in Allogeneic Transplant Recipients Treated With Aminocaproic Acid

Biology of Blood and Marrow Transplantation

Volumn 12, Issue 9, 2006, Pages 949-953

  Wanko, Sam O ^a   Broadwater, Gloria ^b   Folz, Rodney J ^b   Chao, Nelson J ^a  

^a BMT   (United States)

^b DUKE UNIVERSITY MEDICAL CENTER   (United States)

Author keywords

Allogeneic hematopoietic stem cell transplantation; Aminocaproic acid; Corticosteroids; Diffuse alveolar hemorrhage

Indexed keywords

AMINOCAPROIC ACID; CORTICOSTEROID; METHYLPREDNISOLONE SODIUM SUCCINATE;

ADULT; ALLOGENEIC HEMATOPOIETIC STEM CELL TRANSPLANTATION; ARTICLE; BLOOD CLOTTING; CLINICAL ARTICLE; CONTROLLED STUDY; DRUG DOSE REGIMEN; DYSPNEA; FEMALE; GRAFT SURVIVAL; HERPES SIMPLEX; HUMAN; INCIDENCE; LUNG HEMORRHAGE; LUNG LAVAGE; MALE; MEDICAL DECISION MAKING; MORTALITY; MYCOSIS; PHYSICIAN ATTITUDE; RESPIRATORY FAILURE; RESPIRATORY SYNCYTIAL PNEUMOVIRUS; RETROSPECTIVE STUDY; RNA VIRUS INFECTION; TREATMENT FAILURE; TREATMENT OUTCOME; VIRUS INFECTION;

ADULT; AMINOCAPROIC ACIDS; ANTI-INFLAMMATORY AGENTS; FEMALE; HEMATOPOIETIC STEM CELL TRANSPLANTATION; HEMORRHAGE; HUMANS; LUNG DISEASES; MALE; METHYLPREDNISOLONE HEMISUCCINATE; MIDDLE AGED; NEOPLASMS; RESPIRATORY INSUFFICIENCY; RETROSPECTIVE STUDIES; TIME FACTORS;

EID: 33747344544     PISSN: 10838791     EISSN: 15236536     Source Type: Journal    
DOI: 10.1016/j.bbmt.2006.05.012     Document Type: Article

References (31)

1. CIBMTR: Progress Report for January-December 2004. http://www.ibmtr.org/pdf/AnnualReport.pdf 2005:10.
2. Afessa B., Tefferi A., Litzow M.R., and Peters S.G. Outcome of diffuse alveolar hemorrhage in hematopoietic stem cell transplant recipients. Am J Respir Crit Care Med 166 (2002) 1364-1368
3. Roychowdhury M., Pambuccian S.E., Aslan D.L., et al. Pulmonary complications after bone marrow transplantation. an autopsy study from a large transplantation center. Arch Pathol Lab Med 129 (2005) 366-371
4. Chao N.J., Duncan S.R., Long G.D., Horning S.J., and Blume K.G. Corticosteroid therapy for diffuse alveolar hemorrhage in autologous bone marrow transplant recipients. Ann Intern Med 114 (1991) 145-146
5. Cordonnier C., Bernaudin J.F., Bierling P., Huet Y., and Vernant J.P. Pulmonary complications occurring after allogeneic bone marrow transplantation. A study of 130 consecutive transplanted patients. Cancer 58 (1986) 1047-1054
6. Jules-Elysee K., Stover D.E., Yahalom J., White D.A., and Gulati S.C. Pulmonary complications in lymphoma patients treated with high-dose therapy autologous bone marrow transplantation. Am Rev Respir Dis 146 (1992) 485-491
7. Lewis I.D., DeFor T., and Weisdorf D.J. Increasing incidence of diffuse alveolar hemorrhage following allogeneic bone marrow transplantation. cryptic etiology and uncertain therapy. Bone Marrow Transplant 26 (2000) 539-543
8. Metcalf J.P., Rennard S.I., Reed E.C., et al., University of Nebraska Medical Center Bone Marrow Transplant Group. Corticosteroids as adjunctive therapy for diffuse alveolar hemorrhage associated with bone marrow transplantation. Am J Med 96 (1994) 327-334
9. Nevo S., Swan V., Enger C., et al. Acute bleeding after bone marrow transplantation (BMT)-incidence and effect on survival. A quantitative analysis in 1,402 patients. Blood 91 (1998) 1469-1477
10. Raptis A., Mavroudis D., Suffredini A., et al. High-dose corticosteroid therapy for diffuse alveolar hemorrhage in allogeneic bone marrow stem cell transplant recipients. Bone Marrow Transplant 24 (1999) 879-883
11. Robbins R.A., Linder J., Stahl M.G., et al. Diffuse alveolar hemorrhage in autologous bone marrow transplant recipients. Am J Med 87 (1989) 511-518
12. Soubani A.O., Miller K.B., and Hassoun P.M. Pulmonary complications of bone marrow transplantation. Chest 109 (1996) 1066-1077
13. Agusti C., Ramirez J., Picado C., et al. Diffuse alveolar hemorrhage in allogeneic bone marrow transplantation. A postmortem study. Am J Respir Crit Care Med 151 (1995) 1006-1010
14. Ruutu P., Ruutu T., Volin L., Tukiainen P., Ukkonen P., and Hovi T. Cytomegalovirus is frequently isolated in bronchoalveolar lavage fluid of bone marrow transplant recipients without pneumonia. Ann Intern Med 112 (1990) 913-916
15. Benson K., Fields K., Hiemenz J., et al. The platelet-refractory bone marrow transplant patient. prophylaxis and treatment of bleeding. Semin Oncol 20 (1993) 102-109
16. Kang Y., Lewis J.H., Navalgund A., et al. Epsilon-aminocaproic acid for treatment of fibrinolysis during liver transplantation. Anesthesiology 66 (1987) 766-773
17. Lakhani A., Raptis A., Frame D., et al. Intravesicular instillation of E-aminocaproic acid for patients with adenovirus-induced hemorrhagic cystitis. Bone Marrow Transplant 24 (1999) 1259-1260
18. McSorley M.W., and Taraporewalla K.J. Does prophylactic epsilon-aminocaproic acid improve blood loss and coagulation in liver transplantation?. Transplant Proc 23 (1991) 1941
19. Okamoto G.U., and Duperon D.F. Bleeding control after extractions in a patient with aplastic anemia during bone marrow transplantation. report of case. ASDC J Dent Child 56 (1989) 50-55
20. Anaissie E.J., Mahfouz T.H., Aslan T., et al. The natural history of respiratory syncytial virus infection in cancer and transplant patients. implications for management. Blood 103 (2004) 1611-1617
21. Haselton D.J., Klekamp J.G., Christman B.W., and Barr F.E. Use of high-dose corticosteroids and high-frequency oscillatory ventilation for treatment of a child with diffuse alveolar hemorrhage after bone marrow transplantation. case report and review of the literature. Crit Care Med 28 (2000) 245-248
22. Piguet P.F., Grau G.E., Collart M.A., Vassalli P., and Kapanci Y. Pneumopathies of the graft-versus-host reaction. Alveolitis associated with an increased level of tumor necrosis factor mRNA and chronic interstitial pneumonitis. Lab Invest 61 (1989) 37-45
23. Sisson J.H., Thompson A.B., Anderson J.R., et al. Airway inflammation predicts diffuse alveolar hemorrhage during bone marrow transplantation in patients with Hodgkin disease. Am Rev Respir Dis 146 (1992) 439-443
24. Sloane J.P., Depledge M.H., Powles R.L., Morgenstern G.R., Trickey B.S., and Dady P.J. Histopathology of the lung after bone marrow transplantation. J Clin Pathol 36 (1983) 546-554
25. Srivastava A., Gottlieb D., and Bradstock K.F. Diffuse alveolar haemorrhage associated with microangiopathy after allogeneic bone marrow transplantation. Bone Marrow Transplant 15 (1995) 863-867
26. Vaughan W.P., Linder J., Robbins R., Arneson M., and Rennard S.I. Pulmonary surveillance using bronchoscopy and bronchoalveolar lavage during high-dose antineoplastic therapy. Chest 99 (1991) 105-111
27. Wojno K.J., Vogelsang G.B., Beschorner W.E., and Santos G.W. Pulmonary hemorrhage as a cause of death in allogeneic bone marrow recipients with severe acute graft-versus-host disease. Transplantation 57 (1994) 88-92
28. Elliott S.J., and Salcedo J.R. Hematuria after renal allograft biopsy. treatment with aminocaproic acid. Urology 26 (1985) 20-21
29. Humphries J.E., Gonias S.L., Pizzo S.V., and Williams M.E. Life-long bleeding diathesis. effect of orthotopic liver transplantation. Am J Clin Pathol 102 (1994) 816-820
30. Lehr H.A., Waltzer W.C., Anaise D., and Rapaport F.T. Management of a postbiopsy arterial pseudoaneurysm in a transplanted kidney. utilization of epsilon aminocaproic acid and controlled hypotension. Transplant Proc 18 (1986) 976-978
31. Salcedo J.R., and Silverstein C.E. Post-biopsy bleeding in renal allograft. successful treatment with epsilon aminocaproic acid. J Urol 127 (1982) 783