Spine after solid organ transplantation in childhood: A clinical, radiographic, and magnetic resonance imaging analysis of 40 patients

Spine

Volumn 31, Issue 18, 2006, Pages 2130-2136

  Helenius, Ilkka ^a,e   Remes, Ville ^a,b   Tervahartiala, Pekka ^c   Salminen, Sari ^a   Sairanen, Heikki ^a   Holmberg, Christer ^a   Palmu, Petri ^d   Helenius, Miia ^a   Peltonen, Jari ^a   Jalanko, Hannu ^a  

^a HELSINKI UNIVERSITY CENTRAL HOSPITAL   (Finland)

^b Surgical Hospital   (Finland)

^c HELSINKI UNIVERSITY CENTRAL HOSPITAL   (Finland)

^d UNIVERSITY OF HELSINKI   (Finland)

^e NONE   (Finland)

Author keywords

Bone disorder; Children; Disc degeneration; Heart transplantation; Scoliosis; Solid organ transplantation; Spinal deformity; Spinal fractures

Indexed keywords

AZATHIOPRINE; CALCIUM; CORTICOSTEROID; CYCLOSPORIN A; GROWTH HORMONE; IMMUNOSUPPRESSIVE AGENT; METHYLPREDNISOLONE; MYCOPHENOLIC ACID 2 MORPHOLINOETHYL ESTER; TACROLIMUS; VITAMIN D;

ACUTE GRAFT REJECTION; ADOLESCENT; ADULT; BACKACHE; BONE DISEASE; CHILD; CLINICAL ARTICLE; CLINICAL EXAMINATION; CORTICOSTEROID THERAPY; DIAGNOSTIC IMAGING; DIET SUPPLEMENTATION; DISEASE COURSE; FEMALE; FOLLOW UP; HEART TRANSPLANTATION; HORMONAL THERAPY; HUMAN; IMMUNOSUPPRESSIVE TREATMENT; INTERVERTEBRAL DISK; INTERVERTEBRAL DISK DEGENERATION; INTERVERTEBRAL DISK HERNIA; INTERVIEW; KIDNEY TRANSPLANTATION; LIVER TRANSPLANTATION; LUMBAR DISK HERNIA; LUMBOSACRAL SPINE; MALE; NUCLEAR MAGNETIC RESONANCE IMAGING; ORGAN TRANSPLANTATION; PEDIATRIC SURGERY; PHYSICAL EXAMINATION; PRIORITY JOURNAL; QUESTIONNAIRE; REVIEW; RISK; SCOLIOSIS; SPINAL CORD; SPINE FRACTURE; SPINE MALFORMATION; SPINE RADIOGRAPHY; THORACIC SPINE; VERTEBRA BODY; VERTEBRA FRACTURE; VERTEBRAL CANAL;

ADOLESCENT; ADULT; BACK PAIN; BONE DENSITY; CROSS-SECTIONAL STUDIES; FEMALE; HUMANS; IMMUNOSUPPRESSION; IMMUNOSUPPRESSIVE AGENTS; INTERVERTEBRAL DISK DISPLACEMENT; LUMBAR VERTEBRAE; MALE; ORGAN TRANSPLANTATION; POSTOPERATIVE COMPLICATIONS; SCOLIOSIS; SPINAL DISEASES; SPINAL FRACTURES; SPONDYLOLISTHESIS; THORACIC VERTEBRAE;

EID: 33747332823     PISSN: 03622436     EISSN: 15281159     Source Type: Journal    
DOI: 10.1097/01.brs.0000231717.63974.f3     Document Type: Review

References (32)

1. Benfield MR, McDonald RA, Bartosh S, et al. Changing trends in pediatric transplantation: 2001 annual report of the North American Pediatric Renal Transplant Cooperative Study. Pediatr Transplant 2003;7:321-35.
2. Martin SR, Atkison P, Anand R, et al. Studies of Pediatric Liver Transplantation 2002: Patient and graft survival and rejection in pediatric recipients of a first liver transplant in the United States and Canada. Pediatr Transplant 2004;8:273-84.
3. Boucek MM, Edwards LB, Keck BM, et al. The registry of the International Society for Heart and Lung Transplantation: Sixth official pediatric report 2003. J Heart Lung Transplant 2003;22:636-52.
4. Compston J. The skeletal effects of liver transplantation in children. Liver Transpl 2003;9:371-2.
5. Dunn HK, Aiona MD. Spinal instrumentation and fusion for idiopathic scoliosis in a renal transplant patient. A case report. Spine 1982;7:177-9.
6. Ceroni D, Beghett M, Spahr-Schopfer I, et al. Corrective surgery for idiopathic scoliosis after heart transplantation. Eur Spine J 2001;10:454-7.
7. Helenius I, Jalanko H, Remes V, et al. Scoliosis after solid organ transplantation in children and adolescents. Am J Transplant 2006;6:324-30.
8. Ruderman RJ, Poehling GG, Gray R, et al. Orthopedic complications of renal transplantation in children. Transplant Proc 1979;11:104-6.
9. Hill SA, Kelly DA, John PR. Bone fractures in children undergoing orthotopic liver transplantation. Pediatr Radiol 1995;25(suppl 1):S112-7.
10. Sarna S, Laine J, Sipilä I, et al. Differences in linear growth and cortisol production between liver and renal transplant recipients on similar immunosuppression. Transplantation 1995;60:656-61.
11. Bunnell WP. An objective criterion for scoliosis screening. J Bone Joint Surg Am 1984;66:1381-7.
12. Faulkner RA, Bailey DA, Drinkwater DT, et al. Bone densitometry in Canadian children 8-17 years of age. Calcif Tissue Int 1996;59:344-51.
13. Ellis KJ, Shypailo RJ, Hardin DS, et al. Z score prediction model for assessment of bone mineral content in pediatric diseases. J Bone Miner Res 2001; 16:1658-64.
14. Cobb JR. Outline for the study of scoliosis. In: Arbor A, Edwards JW, eds. Instructional Course Lectures. The American Academy of Orthopedic Surgeons. 1948;5:261-75.
15. Lenke LG, Betz RR, Harms J, et al. Adolescent idiopathic scoliosis: A new classification to determine extent of spinal arthrodesis. J Bone Joint Surg Am 2001;83-A:1169-81.
16. Boden SD, Riew DK, Yamaguchi K, et al. Orientation of the lumbar spine facet joints: Association with degenerative disc disease. J Bone Joint Surg Am 1996;78:403-11.
17. Matsumoto M, Fujimura Y, Suzuki N, et al. MRI of cervical intervertebral discs in asymptomatic subjects. J Bone Joint Surg Br 1998;80:19-24.
18. Remes V, Tervahartiala P, Poussa M, et al. Thoracic and lumbar spine in diastrophic dysplasia. A clinical and magnetic resonance imaging analysis. Spine 2001;26:187-95.
19. Mäkitie O, Doria AS, Henriques F. Radiographic vertebral morphology - A diagnostic tool in pediatric osteoporosis. J Pediatr 2005;146:395-401.
20. Modic M, Steinberg P, Ross J, et al. Degenerative disk disease: Assessment of changes in vertebral body marrow with MR imaging. Radiology 1988;166: 193-9.
21. Salminen JJ, Erkintalo MO, Oksanen PJ, et al. Recurrent low back pain and early disc degeneration in the young. Spine 1999;24:1316-21.
22. Leidig-Bruckner G, Hosch S, Dodiou P. Frequency and predictors of osteoporotic fractures after cardiac or liver transplantation: A follow-up study. Lancet 2001;357:342-7.
23. Helenius I, Remes V, Salminen S, et al. Incidence and predictors of fractures in children after solid organ transplantation. A 5-year prospective, population based study. J Bone Miner Res 2006;21:380-7.
24. Ascani E, La Rosa G. Scheurmann's kyphosis. In: Weinstein S, ed. Pediatric Spine. New York, NY: Raven Press; 1994:557-84.
25. Battie MC, Viceman T, Gibbons LE, et al. 1995 Volvo Award in clinical sciences-Determinants of lumbar disc degeneration. Spine 1995;20: 2601-12.
26. Kerttula LI, Serlo WS, Tervonen OA, et al. Post-traumatic findings of the spine after earlier vertebral fracture in young patients: Clinical and MRI study. Spine 2000;25:1104-8.
27. Taimela S, Kujala UM, Salminen JJ, et al. The prevalence of low back pain among children and adolescents: A nationwide cohort-based questionnaire survey in Finland. Spine 1997;22:1132-6.
28. King HA. Back pain in children. Orthop Clin North Am 1999;30:467-74.
29. Karlsson KM, Moller A, Hasserius R, et al. A modeling capacity of vertebral fractures exists during growth-An up to 47-year follow-up. Spine 2003;28:2087-92.
30. Dymling JF, Willner S. Progression of a structural scoliosis during treatment with growth hormone. Acta Orthop Scand 1978;49:264-8.
31. Wang ED, Drummond DS, Dormans JP, et al. Scoliosis in patients with growth hormone. J Pediatr Orthop 1997;17:708-11.
32. Vidil A, Journeau P, Soulie A, et al. Evolution of scoliosis in six children treated with growth hormone. J Pediatr Orthop 2001;10-B:197-200.