The biological action of parathyroid hormone-related peptide (pthrp) and fibroblast growth factor receptor 3 (fgfr3) on bone and cartilage

Acta Anatomica Nipponica

Volumn 75, Issue 5, 2000, Pages 415-425

  Amizuka, Norio ^a   Ozawa, Hidehiro ^a   Sasaki, Tomoyo ^a  

^a NIIGATA UNIVERSITY   (Japan)

Author keywords

Cartilage; Chondrocyte; Fibroblast growth factor receptor type 3 (fgfr3); Gene knock out; Parathyroid hormone related peptide (pthrp)

Indexed keywords

FGFR3 PROTEIN, MOUSE; FIBROBLAST GROWTH FACTOR RECEPTOR; FIBROBLAST GROWTH FACTOR RECEPTOR 3; PARATHYROID HORMONE RELATED PROTEIN; PROTEIN; PROTEIN TYROSINE KINASE;

ANIMAL; CARTILAGE CELL; CELL DIFFERENTIATION; CELL DIVISION; CHONDRODYSPLASIA; CYTOLOGY; GENE DELETION; GENETICS; MOUSE; MOUSE MUTANT; OSTEOBLAST; PHYSIOLOGY; REVIEW;

ANIMALS; CELL DIFFERENTIATION; CELL DIVISION; CHONDROCYTES; GENE DELETION; MICE; MICE, KNOCKOUT; OSTEOBLASTS; OSTEOCHONDRODYSPLASIAS; PARATHYROID HORMONE-RELATED PROTEIN; PROTEIN-TYROSINE KINASES; PROTEINS; RECEPTOR, FIBROBLAST GROWTH FACTOR, TYPE 3; RECEPTORS, FIBROBLAST GROWTH FACTOR;

EID: 33747305862     PISSN: 00227722     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (49)

1. Abou-Samra A-B, Jüppner H, Force T, Freeman MW, Kong XF, Schipani E, Urena P, Richards J, Bonventre JV, Potts JT, Kronenberg HM, Segre GV (1992) Expression cloning of a common receptor for parathyroid hormone and parathyroid hormone-related peptide from rat osteoblast-like cells: a single receptor stimulates intracellular accumulation of both cAMP and inositol triphosphates and increases intracellular free calcium. Proc Natl Acad Sei USA 89: 2732-2736
2. Amizuka N, Warshawsky H, Henderson JE, Goltzman D, Karaplis AC (1994) Parathyroid hormone-related peptide (PTHrP)-depleted mice show abnormal epiphyseal cartilage and altered endochondral bone formation. J CellBiol 126: 1611-1623
3. Amizuka N, Karaplis AC, Henderson JE, Warshawsky H, Lipman ML, Matsuki Y, Ejiri S, Tanaka M, Izumi N, Ozawa H, Goltzman D (1996a) Haploinsufficiency of parathyroid hormone-related peptide (PTHrP) results in abnormal post-natal bone development. Dev Biol 175: 166-176
4. Amizuka N, Karaplis AC, Henderson JE, Hoshi K, Warshawsky H, Ozawa H, Goltzman D (1996b) Programmed cell death of chondrocytes and aberrant chondrogenesis in mice homozygous for parathyroid hormone-related peptide (PTHrP) gene deletion. Endocrinology 137: 5055-5067
5. Amizuka N, Goltzman D, Ozawa H (1996c) The biologic action of parathyroid hormone-related peptide on bone cells. Tissue Engineering 2: 277-287
6. Amizuka N, Kwan M, Goltzman D, Ozawa H, White JH (1999) Vitamin D3 differentially regulates parathyroid hormone/parathyroid hormone-related peptide receptor expression in bone and cartilage. J Clin Invest 103: 373-381
7. Bellus GA, Bamshad MJ, Przylepa KA, Dorst J, Lee RR, Hurko O, Jabs EW, Curry CJ, Wilcox WR, Lachman RS, Rimoin DL, Francomano CA (1999) Severe achondroplasia with developmental delay and acanthosis nigricans (SADDAN): phenotypic analysis of a new skeletal dysplasia caused by a Lys650Met mutation in fibroblast growth factor receptor 3. Am J Med Gene 85: 53-65
8. Burtis WJ, Wu T, Bunch C, Wysolmerski JJ, Isogna KL, Weir EC, Broadus AE, Stewart AF (1987) Identification of a novel 17,000-dalton parathyroid hormone-like adenylate cyclase-stimulating protein from a tumor associated with humoral hypercalcemia of malignancy. J Biol Chem 161: 7151-7156
9. Chen L, Adar R, Yang X, Monsonego EO, Li C, Hauschka PV, Yayon A, Deng CX (1999) Gly369Cys mutation in mouse FGFR3 causes achondroplasia by affecting both chondrogenesis and osteogenesis. J Clin Invest 104: 1517-1525
10. Chitayat D, Fernahdez B, Gardner A, Moore L, Glance P, Dunn M, Chun K, Sgro M, Ray P, AllinghamHawkins D (1999) Compound heterozygosity for the Achondroplasia-hypochondroplasia FGFR3 mutations: prenatal diagnosis and postnatal outcome. Am J Med Gene 84: 401-405
11. Colvin JS, Bohne BA, Harding GW, McEwen DG, Ornitz DM (1996) Skeletal overgrowth and deafness in mice lacking fibroblast growth factor receptor 3. Nature Genetics 12: 390-397
12. Deftos LJ, Burton DW, Brant DW (1993) Parathyroid hormone-like protein is a secretory product of atrial myocytes. J Clin Invest 92: 727-735
13. Drucker DJ, Asa SL, Henderson J, Goltzman D (1989) The parathyroid hormone-like peptide gene is expressed in the normal and neoplastic human endocrine pancreas. Mol Endocrinol 3: 1589-1595
14. Emonoto H, Yamashita S, Usa T, Namba H, Ohtsuru A, Villadolid MC, Tsukazaki T, Matsumoto T, Iwasaki K (1993) Autocrine/paracrine function of parathyroid hormone-related peptide in rat osteoblast-Iike cells. Biochem Biophys Res Commun 191: 1261-1269
15. Goltzman D, Hendy GN (1995) Parathyroid hormone. In: Becker KL (ed) Principles and Practice of Endocrinology and Metabolism, 2nd ed, J.B. Lippincott Co, Philadelphia, pp 455-467
16. Horiuchi N, Caulfield MP, Fisher JE, Goldman ME, McKee GR, Reagan JE, Levy JJ, Nutt RF, Rodan SB, Clemens TL, Rosenblatt M (1987) Similarity of synthetic peptide fron human tumor to parathyroid hormone in vivo and in vitro. Science 238: 1566-1568
17. Huggins MJ, Smith JR, Chun K, Ray PN, Shah JK, Whelan DT (1999) Achondroplasia-hypochondroplasia complex in a newborn infant. Am J Med Gene 84: 396-400
18. Ikeda K, Weir EC, Mangin M, Dannies PS, Kinder B, Deftos LJ, Brown EM, Broadus AE (1988) Expression of messenger ribonucleic acids encoding a parathyroid hormone-like peptide in normal human and animal tissues with abnormal expression in human parathyroid adenomas. Mol Endocrinol 2: 1230-1236
19. Irie K, Ozawa H (1996) Immunohistochemical localization of parathyroid hormone/parathyroid hormonerelated peptide receptor in rat tibiae. J Bone Miner Metab 14: 10-14
20. Jüppner H, Abou-Samra A-B, Freeman M, Kong XF, Schipani E, Richards J, Kolakowski Jr LF, Hock J, Potts Jr JT, Kronenberg HM, Segre GV (1991) A G proteinlinked receptor for parathyroid hormone and parathyroid hormone-related peptide. Science 254: 10241026
21. Kaiser S, Laneuville P, Bernier SM, Rhim JS, Kremer R, Goltzman D (1992) Enhanced growth of a human keratinocyte cell line induced by antisense RNA for parathyroid hormone-related peptide. J Biol Chem 267: 13623-13628
22. Kaiser SM, Sebag M, Rhim JS, Kremer R, Goltzman D (1994) Antisense-mediated inhibition of parathyroid hormone-related peptide (PTHrP) production in a keratinocyte cell line impedes differentiation. Mol Endocrinol 8: 139-147
23. Karaplis AC, Luz A, Glowacki J, Bronson RT, Tybulewicz VLJ, Kronenberg HM, Mulligan RC (1994) Lethal skeletal dysplasia from targeted disruption of the parathyroid hormone-related peptide (PTHrP) gene. Genes Dev 8: 277-289
24. Kemp BE, Moseley JM, Rodda CP, Ebeling PR, Wettenhall REH, Stapleton D, Diefenbach-Jagger N, Ure F, Michlangeli VP, Simmons HA, Raisz LG, Martin TJ (1987) Parathyroid hormone-related protein of malignancy: active synthetic fragments. Science 238: 1568-1570
25. Lanske B, Karaplis AC, Lee K, Luz A, Vortkamp A, Pirro A, Karperien M, Defize LHK, Ho C, Mulligan RC, Abou-Samra AB, Jüppner H, Segre GV, Kronenberg HM (1996) PTH/PTHrP receptor in early development and Indian hedgehog-regulated bone growth. Science 273: 663-666
26. Lee K, Deeds JD, Chiba S, Un-no M, Bond AT, Segre GV (1994) Parathyroid hormone iduces sequential c-fos expression in bone cells in vivo: In situ hybridization of its receptor and c-fos messenger ribonucleic acid. Endocrinology 134: 441-450
27. Li C, Chen L, Iwata T, Kitagawa M, Fu XY, Deng CX (1999) A Lys644Glu substitution in fibroblast growth factor receptor 3 (FGFR3) causes dwarfism in mice by activation of STATs and ink4 cell cycle inhibitors. Hum Mol Genet 8: 35-44
28. Lomri A, de Pollak C, Sebag M, Goltzman D, Kremer R, Marie PJ (1997) Expression of parathyroid hormonerelated peptide (PTHrP) and PTH/PTHrP receptor in newborn human calvaria osteoblastic cells. Eur J Endocrinol 136: 640-648
29. Merendino JJ, Isogna Jr KL, Milstone LM, Broadus AE, Stewart AF (1986) A parathyroid hormone-like protein from cultured human keratinocytes. Science 231: 388390
30. Moseley JM, Hayman JA, Danks JA, Alcorn D, Grill V, Southby J, Horton MA (1991) Immunohistochemical detection of parathyroid hormone-related protein in human fetal epithelia. J Clin Endocrinol Metab 73: 478-484
31. Naski MC, Wang Q, Xu J, Ornitz DM (1996) Graded activation of fibroblast growth factor receptor 3 by mutations causing achondroplasia and thanatophoric dysplasia. Nature Genetics 13: 233-237
32. Peters KG, Werner S, Chen G, Williams LT (1992) Two FGF receptor genes are differentially expressed in epithelial and mesenchymal tissues during limb formation and organogenesis in the mouse. Development 114: 233-243
33. Peters K, Ornitz D, Werner S, Williams L (1993) Unique expression pattern of the FGF receptor 3 gene during mouse organogenesis. Dev Biol 155: 423-430
34. Rabbani SA, Mitchell J, Roy DR, Hendy ON, Goltzman D (1988) Influence of the amino-terminus on in vitro biological activity of synthetic parathyroid hormone-like peptides of malignancy. Endocrinology 123: 2709-2716
35. Rouleau MF, Warshawsky H, Goltzman D (1986) Parathyroid hormone binding in vivo to renal, hepatic, and skeletal tissues of the rat using a radioautographic approach. Endocrinology 118: 919-931
36. Rouleau MF, Mitchell J, Goltzman D (1988) In vivo distribution of parathyroid hormone receptors in bone: evidence that a predominant osseus target cell is not the mature osteoblast. Endocrinology 123: 187-191
37. Rouleau MF, Mitchell J, Goltzman D (1990) Characterization of the major parathyroid hormone target cell in the endosteal metaphysis of rat long bones. J Bone Miner Res 5: 1043-1053
38. Rousseau F, Bonaventure J, Legeai-Mallet L, Pelet A, Rozet JM, Maroteaux P, Le Merrer M, Munnich A (1994) Mutations in the gene encoding fibroblast growth factor receptor-3 in achondroplasia. Nature 371: 252-254
39. Senior PV, Heath DA, Beck F (1990) Expression of parathyroid hormone-related protein mRNA in the rat before birth: demonstration by hybridization histochemistry. J Mol Endocrinol 6: 281-290
40. Shiang R, Thompson LM, Zhu YZ, Church DM, Fielder TJ, Bocian M, Winokur ST, Wasmuth JJ (1994) Mutations in the transmembrane domain of FGFR3 cause the most common genetic form of dwarfism, achondroplasia. Cell 78: 335-342
41. Strewler G, Stern JPH, Jacob JW, Eveloff J, Klein RF, Leung SC, Rosenblatt M, Nissenson RA (1987) Parathyroid hormonelike protein from human renal carcinoma cells: structural and functional homology with parathyroid hormone. J Clin Invest 80: 1803-1807
42. Suda N, Gillespie MT, Traianedes K, Zhou H, Ho PWM, Hards DK, Allan EH, Martin TJ, Moseley JM (1996) Expression of parathyroid hormone-related protein in cells of osteoblast lineage. J Cell Physiol 166: 94-104
43. Suva LJ, Winslow GA, Wettenhall REH, Hammond RG, Moseley JM, Diefenbach-Jaggar H, Rodda CP, Kemp BE, Rodriguez H, Chen EY, Hudson PJ, Martin TJ, Wood WI (1987) A parathyroid hormone-related protein implicated malignant hypercalcemia: cloning and expression. Science 237: 893-896
44. Thiede MA, Rodan GA (1989) Expression of a calcium mobilizing parathyroid hormone-like peptide in lactating mammary tissue. Science 242: 278-280
45. Thiede MA, Daifotis AG, Weir EC, Brines ML, Burtis WJ, Ikeda K, Dreyer BE, Garfield RE, Broadus AE (1990) Intrauterine occupancy controls expression of the parathyroid hormone-related peptide gene in prêterai rat myometrium. Proc Natl Acad Sei USA 87: 6969-6973
46. Thompson DD, Seedor JG, Fisher JE, Rosenblatt M, Rodan GA (1988) Direct action of the parathyroid hormone-like human hypercalcémie factor on bone. Proc Natl Acad Sei USA 85: 5673-5677
47. Tsukazaki T, Ohtsuru A, Enomoto H, Yano H, Motomura K, Ito M, Namba H, Iwasaki K, Yamashita S (1995) Expression of parathyriod hormone-related protein in rat articular cartilage. Calcif Tissue Int 57: 196-200
48. Urena P, Kong XF, Abou-Samra AB, Jüppner H, Kronenberg HM, Potts Jr JT, Segre GV (1993) Parathyroid hormone (PTH)/PTH-related peptide receptor messenger ribonucleic acids are widely distributed in rat tissues. Endocrinology 133: 617-623
49. Wang Y, Spatz MK, Kannan K, Hayk H, Avivi A, Gorivodsky M, Pines M, Yayon A, Lonai P, Givol D (1999) A mouse model for achondroplasia produced by targeting fibroblast growth factor receptor 3. Proc Natl Acad Sci USA 96: 4455-4460