Virological analysis, genotypes and mutational patterns of the HBV precore/core gene in HBV/HCV-related hepatocellular carcinoma

Journal of Viral Hepatitis

Volumn 13, Issue 9, 2006, Pages 574-581

  De Mitri, M S ^a,c   Cassini, R ^a   Morsica, G ^b   Bagaglio, S ^b   Andreone, P ^a   Loggi, E ^a   Muratori, P ^a   Bernardi, M ^a  

^a UNIVERSITY OF BOLOGNA   (Italy)

^b SAN RAFFAELE HOSPITAL   (Italy)

^c UNIVERSITY OF BOLOGNA   (Italy)

Author keywords

Hepatitis B virus; Hepatitis C virus; Hepatocellular carcinoma; Precore

Indexed keywords

CYTOSINE; THYMINE;

ADULT; ARTICLE; CLINICAL ARTICLE; CONTROLLED STUDY; DISEASE COURSE; FEMALE; GENE SEQUENCE; GENETIC VARIABILITY; GENOTYPE; HEPATITIS B VIRUS; HEPATITIS C VIRUS; HUMAN; HUMAN TISSUE; LIVER CARCINOGENESIS; LIVER CELL CARCINOMA; MALE; NONHUMAN; NUCLEIC ACID BASE SUBSTITUTION; PRIORITY JOURNAL; SUPERINFECTION; VIREMIA; VIROLOGY; VIRUS CAPSID; VIRUS GENE; VIRUS GENOME; VIRUS MUTATION; VIRUS REPLICATION;

ADULT; AGED; BASE SEQUENCE; CARCINOMA, HEPATOCELLULAR; CHILD; FEMALE; GENOME, VIRAL; GENOTYPE; HEPACIVIRUS; HEPATITIS B; HEPATITIS B VIRUS; HEPATITIS C; HUMANS; LIVER NEOPLASMS; MALE; MIDDLE AGED; MOLECULAR SEQUENCE DATA; MUTATION; VIRAL CORE PROTEINS; VIRAL LOAD; VIREMIA; VIRUS REPLICATION;

EID: 33747298123     PISSN: 13520504     EISSN: 13652893     Source Type: Journal    
DOI: 10.1111/j.1365-2893.2006.00726.x     Document Type: Article

References (45)

1. Colombo M, Sangiovanni A. Etiology, natural history and treatment of hepatocellular carcinoma. Antiviral Res 2003; 60: 145-150.
2. Benvegnù L, Fattovich G, Noventa F et al. Concurrent hepatitis B and C virus infection and risk of hepatocellular carcinoma in cirrhosis. A prospective study. Cancer 1994; 74: 2442-2448.
3. Kaklamani E, Trichopulos D, Tzonou A et al. Hepatitis B and C viruses and their interaction in the origin of hepatocellular carcinoma. JAMA 1991; 256: 1974-1976.
4. Alberti A, Pontisso P, Chemello L et al. The interaction between hepatitis B virus and hepatitis C virus in acute and chronic liver disease. J Hepatol 1995; 22: 38-41.
5. Ruiz J, Sangro B, Cuende JI et al. Hepatitis B and C infections in patients with hepatocellular carcinoma. Hepatology 1992; 16: 637-641.
6. Hino O, Kajino K. Hepatitis virus-related hepatocarcinogenesis. Intervirology 1994; 37: 133-135.
7. Crespo J, Lozano JL, Carte B, Heras B, Cruz F, Pons Romero F. Viral replication in patients with concomitant hepatitis B and C virus infection. Eur J Clin Microbiol Infect Dis 1997; 16: 445-451.
8. Liaw YF, Tsai SL, Chang JJ et al. Displacement of hepatitis B virus by hepatitis C virus as the cause of continuing chronic hepatitis. Gastroenterology 1994; 106: 1048-1053.
9. Zarski JP, Bohn B, Bastie A et al. Characteristics of patients with dual infection by hepatitis B and C viruses. J Hepatol 1998; 28: 27-33.
10. Koike K, Yasuda K, Yotsuyanagi H et al. Dominant replication of either virus in dual infection with hepatitis viruses B and C. J Med Virol 1995; 45: 236-239.
11. Pontisso P, Ruvoletto MG, Fattovich G et al. Clinical and virological profiles in patients with multiple hepatitis virus infection. Gastroenterology 1993; 105: 1529-1533.
12. Hunt CM, McGill JM, Allen MI, Condreay LD. Clinical relevance of hepatitis B viral mutations. Hepatology 2000; 31: 1037-1044.
13. Brunetto MR, Rodriguez UA, Bonino F. Hepatitis B virus mutants. Intervirology 1999; 42: 69-80.
14. Grandjacques C, Pradat P, Stuyver L et al. Rapid detection of genotypes and mutations in the pre-core promoter and the pre-core region of hepatitis B virus genome: correlation with viral persistence and liver disease severity. J Hepatol 2000; 33: 430-439.
15. Brunetto MR, Giarin M, Olivieri F et al. Wild type and e antigen-minus hepatitis B virus in course of chronic hepatitis. Proc Natl Acad Sci USA 1991; 88: 4186-4190.
16. Rodriguez-Frias F, Buti M, Jardi R et al. Hepatitis B virus infection: precore mutants and its relation to viral genotypes and core mutations. Hepatology 1995; 22: 1641-1647.
17. Lindh M, Furuta Y, Vahlne A, Norkrans G, Horal P. Emergence of precore TAG mutation during hepatitis B sero-conversion and its dependence on pregenomic base pairing between nucleotides 1958 and 1896. J Infect Dis 1995; 172: 1343-1347.
18. Minami M, Poussin K, Kew M, Okanoue T, Brechot C, Paterlini P. Precore/core mutations of hepatitis B virus in hepatocellular carcinomas developed on noncirrhotic livers. Gastroenterology 1996; 111: 691-700.
19. Blackberg J, Kidd-Ljunggren K. Mutation within the hepatitis B virus genome among chronic hepatitis B patients with hepatocellular carcinoma. J Med Virol 2003; 71: 18-23.
20. Junker-Niebman M, Bartenschlager R, Schaller H. A short cis-acting sequence is required for hepatitis B pregenome encapsidation and sufficient for packaging of foreign DNA. EMBO J 1990; 9: 3389-3396.
21. Pollack J, Ganem D. An RNA stem-loop structure directs hepatitis B virus genomic RNA encapsidation. J Virol 1993; 67: 3254-3263.
22. Omata M, Ehata T, Yousuka O, Hosoda K, Ohto M. Mutation in the precore region of hepatitis B virus DNA in patients with fulminant and severe hepatitis. N Engl J Med 1991; 324: 1699-1704.
23. Tong S-P, Li J-S, Vitvitski L, Trepò C. Replication capacities of natural and artificial precore stop codon mutants of hepatitis B virus: Relevance of pregenome encapsidation signal. Virology 1992; 191: 237-245.
24. Lok ASF, Akarca U, Greene S. Mutations in the pre-core region of hepatitis B virus serve to enhance the stability of the secondary structure of the pre-genome encapsidation signal. Proc Natl Aca Sci USA 1994; 91: 4077-4081.
25. Alestig E, Hannoun C, Horal P, Lindh M. Phylogenetic origin of hepatitis B virus strains with precore C-1858 variant. J Clin Microbiol 2001; 39: 3200-3203.
26. Kramvis A, Kew MC. Structure and function of the encapsidation signal of hepadnaviridae. J Viral Hepat 1998; 5: 357-367.
27. Chomczynsky P, Sacchi N. Single step method of RNA isolation by acid guanidinium thiocyanate-phenol-chlorophorm extraction. Anal Biochem 1987; 162: 156-159.
28. Paterlini P, Poussin K, D'Errico A et al. Rate of persistence, structure, and expression of HBV genome in HCC developing in HBsAg-negative patients. In: Nishika K, Suzuki H, Mishiro S, Oda T, eds. Viral Hepatitis and Liver Disease. Tokyo: Springer-Verlag, 1994: 757-762.
29. De Mitri MS, Poussin K, Baccarini P et al. HCV-associated liver cancer without cirrhosis. Lancet 1995; 345: 413-415.
30. Morsica G, Novati R, Lazzarin A. Detection of hepatitis virus RNA by methods using phenol-chlorophorm or silica particles. J Clin Microbiol 1995; 33: 2522-2523.
31. Hannoun C, Krogsgaard K, Horal P, Lindh M, the INTERPRETED Trial Group. Genotype mixtures of hepatitis B virus in patients treated with interferon. J Infect Dis 2002; 186: 752-759.
32. Thompson JD, Gibson TJ, Plewniak F, Jeanmougin F, Higging DG. The CLUSTAL _X windows interface: flexible strategies for multiple sequence alignment aided by quality analysis tools. Nucleic Acids Res 1997; 25: 4876-4882.
33. Shiratori Y, Shiina S, Zhang PY et al. Does dual infection by hepatitis B and C viruses play an important role in the pathogenesis of hepatocellular carcinoma in Japan? Cancer 1997; 80: 1060-1067.
34. Tanaka T, Inoue K, Hayashi Y et al. Virological significance of low-level hepatitis B virus infection in patients with hepatitis C virus associated liver disease. J Med Virol 2004; 72: 223-229.
35. Sagnelli E, Coppola N, Scolastico C et al. Virological and clinical expression of reciprocal inhibitory effect of hepatitis B, C, and Delta viruses in patients with chronic hepatitis. Hepatology 2000; 32: 1106-1110.
36. Kao J-H. Hepatitis B viral genotypes: clinical relevance and molecular characteristics. J Gastroentrol Hepatol 2002; 17: 643-650.
37. Kao JH, Chen PJ, Lai MY, Chen DS. Hepatitis B genotypes correlate with clinical outcomes in patients with chronic hepatitis B. Gastroenterology 2000; 118: 554-559.
38. Tsubota A, Arase Y, Ren F, Tanaka H, Ikeda K, Kumada H. Genotype may correlate with liver carcinogenesis and tumor characteristics in cirrhotic patients infected with hepatitis B virus subtype adw. J Med Virol 2001; 65: 257-265.
39. Shih CM, Lo SJ, Miyamura T, Chen SY, Wu Le YH. Suppression of hepatitis B virus expression and replication by hepatitis C virus core protein in HuH-7 cells. J Virol 1993; 67: 5823-5832.
40. Chen SY, Kao CF, Chen CM et al. Mechanisms for inhibition of hepatitis B virus gene expression and replication by hepatitis C virus core protein. J Biol Chem 2003; 278: 591-607.
41. Jardi R, Rodriguez F, Buti M et al. Role of hepatitis B, C, and D viruses in dual and triple infection: influence of viral genotypes and hepatitis B precore and basal promoter mutations on viral replicative interference. Hepatology 2001; 34: 404-410.
42. Yeh CHT, Chiu CHT, Tsa SL, Hong ST, Chu CHM, Liaw YF. Absence of precore mutant in dual (B and C) and triple (B, C, D) hepatitis virus infection. J Infec Dis 1994; 170: 1582-1585.
43. Yuan TT, Faruki A, Shih JW, Shih C. The mechanism of the natural occurrence of two closely linked HBV precore predominant mutations. Virology 1995; 211: 144-156.
44. McMillian JS, Bowden DS, Angus PW, McCaughan GW, Locarnini SA. Mutations in the hepatitis B virus Precore/Core gene and in Core Promoter in patients with severe recurrent disease following liver transplantation. Hepatology 1996; 24: 1371-1378.
45. Blum HE. Variants of hepatitis B, C and D viruses: molecular biology and clinical significance. Digestion 1995; 56: 85-95.