Thrombospondin-4 1186G>C (A387P) is a sex-dependent risk factor for myocardial infarction: A large replication study with increased sample size from the same population

American Heart Journal

Volumn 152, Issue 3, 2006, Pages 543.e1-543.e5

  Cui, Jianxun ^a   Randell, Edward ^a   Renouf, James ^b   Sun, Guang ^a   Green, Roger ^a   Han, Fei Yu ^a   Xie, Ya Gang ^a  

^a MEMORIAL UNIVERSITY OF NEWFOUNDLAND   (Canada)

^b Health Care Corporation of St John's   (Canada)

Author keywords

[No Author keywords available]

Indexed keywords

AMINO ACID; THROMBOSPONDIN; THROMBOSPONDIN 4; UNCLASSIFIED DRUG;

ADULT; AMINO ACID SUBSTITUTION; ARTICLE; CARDIOVASCULAR RISK; CASE CONTROL STUDY; COHORT ANALYSIS; CONTROLLED STUDY; FEMALE; GENETIC ANALYSIS; GENETIC ASSOCIATION; GENETIC RISK; GENETIC SIMILARITY; GENETIC VARIABILITY; GENOTYPE; HEART INFARCTION; HOMOZYGOSITY; HUMAN; MAJOR CLINICAL STUDY; MALE; POPULATION RESEARCH; PRIORITY JOURNAL; REAL TIME POLYMERASE CHAIN REACTION; RISK ASSESSMENT; RISK FACTOR; SAMPLE SIZE; SEX RATIO; STATISTICAL SIGNIFICANCE; VALIDATION STUDY;

EID: 33747190400     PISSN: 00028703     EISSN: 10976744     Source Type: Journal    
DOI: 10.1016/j.ahj.2006.06.002     Document Type: Article

References (15)

1. Ioannidis J.P., Ntzani E.E., Trikalinos T.A., et al. Replication validity of genetic association studies. Nat Genet 29 (2001) 306-309
2. Hirschhorn J.N., and Altshuler D. Once and again-issues surrounding replication in genetic association studies. J Clin Endocrinol Metab 87 (2002) 4438-4441
3. Colhoun H.M., McKeigue P.M., and Davey Smith G. Problems of reporting genetic associations with complex outcomes. Lancet 361 (2003) 865-872
4. Hegele R.A. SNP judgments and freedom of association. Arterioscler Thromb Vasc Biol 22 (2002) 1058-1061
5. Wight T.N., Raugi G.J., Mumby S.M., et al. Light microscopic immunolocation of thrombospondin in human tissues. J Histochem Cytochem 33 (1985) 295-302
6. Lawler J., Duquette M., Whittaker C.A., et al. Identification and characterization of thrombospondin-4, a new member of the thrombospondin gene family. J Cell Biol 120 (1993) 1059-1067
7. Stenina O.I., Desai S.Y., Krukovets I., et al. Thrombospondin-4 and its variants: expression and differential effects on endothelial cells. Circulation 108 (2003) 1514-1519
8. Majack R.A., Cook S.C., and Bornstein P. Control of smooth muscle cell growth by components of the extracellular matrix: autocrine role for thrombospondin. Proc Natl Acad Sci U S A 83 (1986) 9050-9054
9. Taraboletti G., Roberts D., Liotta L.A., et al. Platelet thrombospondin modulates endothelial cell adhesion, motility, and growth: a potential angiogenesis regulatory factor. J Cell Biol 111 (1990) 765-772
10. Narouz-Ott L., Maurer P., Nitsche D.P., et al. Thrombospondin-4 binds specifically to both collagenous and non-collagenous extracellular matrix proteins via its C-terminal domains. J Biol Chem 275 (2000) 37110-37117
11. Bornstein P. Thrombospondins: structure and regulation of expression. FASEB J 6 (1992) 3290-3299
12. Geourjon C., and Deleage G. SOPM: a self-optimized method for protein secondary structure prediction. Protein Eng 7 (1994) 157-164
13. Cui J., Randell E., Renouf J., et al. Gender dependent association of thrombospondin-4 A387P polymorphism with myocardial infarction. Arterioscler Thromb Vasc Biol 24 (2004) e183-e184
14. Bear J.C., Nemec T.F., Kennedy J.C., et al. Persistent genetic isolation in outport Newfoundland. Am J Med Genet 27 (1987) 807-830
15. Martin L.J., Crawford M.H., Koertvelyessy T., et al. The population structure of ten Newfoundland outports. Hum Biol 72 (2000) 997-1016