Structures of new amphidinols with truncated polyhydroxyl chain and their membrane-permeabilizing activities

Bioorganic and Medicinal Chemistry

Volumn 14, Issue 19, 2006, Pages 6548-6554

  Morsy, Nagy ^a   Houdai, Toshihiro ^a   Matsuoka, Shigeru ^a   Matsumori, Nobuaki ^a   Adachi, Seiji ^a   Oishi, Tohru ^a   Murata, Michio ^a   Iwashita, Takashi ^b   Fujita, Tsuyoshi ^b  

^a OSAKA UNIVERSITY   (Japan)

^b SUNTORY INSTITUTE FOR BIOORGANIC RESEARCH   (Japan)

Author keywords

Amphidinol; Antifungal; Hemolysis; Membrane permeabilization; Structure elucidation; Structure activity relationship

Indexed keywords

AMPHIDINOL DERIVATIVE; ANTIFUNGAL AGENT; POLYENE; UNCLASSIFIED DRUG;

ARTICLE; BIOLOGICAL ACTIVITY; COLLISIONALLY ACTIVATED DISSOCIATION; CONTROLLED STUDY; DINOFLAGELLATE; DRUG ISOLATION; DRUG STRUCTURE; FUNGUS CULTURE; HYDROPHOBICITY; MASS SPECTROMETRY; MEMBRANE PERMEABILITY; MEMBRANE TRANSPORT; NONHUMAN; NUCLEAR MAGNETIC RESONANCE; POROSITY; STRUCTURE ACTIVITY RELATION;

ALKENES; ANIMALS; ANTIFUNGAL AGENTS; ASPERGILLUS; CELL MEMBRANE PERMEABILITY; CHEMISTRY, PHYSICAL; DINOFLAGELLIDA; ERYTHROCYTES; FUNGI; HEMOLYSIS; HUMANS; MAGNETIC RESONANCE SPECTROSCOPY; MASS SPECTROMETRY; MICROBIAL SENSITIVITY TESTS; PYRANS; SPECTROMETRY, MASS, ELECTROSPRAY IONIZATION; SPECTROPHOTOMETRY, ULTRAVIOLET; STRUCTURE-ACTIVITY RELATIONSHIP;

AMPHIDINIUM KLEBSII; DINOPHYCEAE;

EID: 33747159389     PISSN: 09680896     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.bmc.2006.06.012     Document Type: Article

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