Air-oxidized products of multi-component reactions between 3-amino-1,2,4-triazole, aromatic aldehydes and isonitriles

Tetrahedron Letters

Volumn 47, Issue 38, 2006, Pages 6891-6894

  Parchinsky, Vladislav Z ^a   Koleda, Vladimir V ^a   Shuvalova, Olga ^a   Kravchenko, Dmitry V ^a   Krasavin, Mikhail ^a  

^a Chemical Diversity Research Institute   (Russian Federation)

Author keywords

Air oxidation; Combinatorial chemistry; Imidazo 1,2 b 1,2,4 triazoles; Intramolecular Ugi reaction

Indexed keywords

ACID; ALDEHYDE; HETEROCYCLIC COMPOUND; IMIDAZOLE DERIVATIVE; ISONITRILE DERIVATIVE; TRIAZOLE DERIVATIVE;

AIR; ARTICLE; CARBON NUCLEAR MAGNETIC RESONANCE; CHEMICAL REACTION; CHEMICAL STRUCTURE; COMBINATORIAL CHEMISTRY; GROEBKE REACTION; HYDROLYSIS; MOLECULAR STABILITY; OXIDATION; PROTON NUCLEAR MAGNETIC RESONANCE; REACTION OPTIMIZATION;

EID: 33747153311     PISSN: 00404039     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.tetlet.2006.07.037     Document Type: Article

References (13)

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9. The nonoxidized imidazo[1,2-b][1,2,4]triazoles 2 were sometimes present in the reaction mixtures and disappeared after prolonged exposure of the methanolic solutions to ambient atmosphere, as indicated by repeated LC MS analysis.
10. Additional extraction of the MeOH-water phase with ethyl acetate was required in some cases.
11. 2 requires 361.4067.
12. Crystallographic data (excluding structure factors) for structure 3b have been deposited with the Cambridge Crystallographic Data Centre as supplementary publication number CCDC 614188. Copies of the data can be obtained free of charge, on application to CCDC, 12 Union Road, Cambridge CB2 1EZ, UK [fax: +44(0)-1223-336033 or email: deposit@ccdc.cam.ac.uk].
13. 5O requires 305.3420.