The importance of the cosolvent propylene glycol on the antimicrobial preservative efficacy of a pharmaceutical formulation by DOE-ruggedness testing

Pharmaceutical Development and Technology

Volumn 11, Issue 3, 2006, Pages 275-284

  De Spiegeleer, B ^a   Wattyn, E ^a   Slegers, G ^a   Van Der Meeren, P ^a   Vlaminck, K ^b   Van Vooren, L ^c  

^a GHENT UNIVERSITY   (Belgium)

^b JANSSEN RESEARCH FOUNDATION   (Belgium)

^c Pharm Vize (Formerly HEA)   (Belgium)

Author keywords

Cosolvent; Design of experiments (DOE); Parabens; Preservative efficacy test (PET); Propylene glycol; Robustness; Suspension emulsion

Indexed keywords

DRUG PRESERVATIVE; METHYL PARABEN; PROPYL PARABEN; PROPYLENE GLYCOL; SOLVENT;

ANTIMICROBIAL ACTIVITY; ARTICLE; ASPERGILLUS NIGER; BACTERIAL STRAIN; BOX BEHNKEN DESIGN; CANDIDA ALBICANS; COLONY FORMING UNIT; CONTROLLED STUDY; DESIGN OF EXPERIMENT; DRUG EFFICACY; DRUG FORMULATION; DRUG INFORMATION; EMULSION; EXPERIMENTAL DESIGN; FUNGAL STRAIN; LINEAR REGRESSION ANALYSIS; MEDICAL LITERATURE; METHODOLOGY; NONHUMAN; PRESERVATIVE EFFICACY TEST; PRIORITY JOURNAL; PRODUCT DEVELOPMENT; RUGGEDNESS TEST; STATISTICAL ANALYSIS; SUSPENSION;

ANTI-INFECTIVE AGENTS; ASPERGILLUS NIGER; CANDIDA ALBICANS; CHEMISTRY, PHARMACEUTICAL; COLONY COUNT, MICROBIAL; EMULSIONS; MICROBIAL SENSITIVITY TESTS; PARABENS; PHARMACEUTICAL PREPARATIONS; PRESERVATIVES, PHARMACEUTICAL; PROPYLENE GLYCOL; RESEARCH DESIGN; SOLVENTS; SUSPENSIONS; TECHNOLOGY, PHARMACEUTICAL;

EID: 33747145549     PISSN: 10837450     EISSN: 10979867     Source Type: Journal    
DOI: 10.1080/10837450600767342     Document Type: Article

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