Comparative elution of moxifloxacin from Norian skeletal repair system and acrylic bone cement: an in vitro study

International Journal of Antimicrobial Agents

Volumn 28, Issue 3, 2006, Pages 217-220

  Kanellakopoulou, Kyriaki ^a   Tsaganos, Thomas ^a   Athanassiou, Kalomira ^a   Koutoukas, Pantelis ^a   Raftogiannis, Maria ^a   Skiadas, Ioannis ^a   Giamarellou, Helen ^a  

^a UNIVERSITY OF ATHENS MEDICAL SCHOOL   (Greece)

Author keywords

Biodegradable carrier; Moxifloxacin; Norian

Indexed keywords

ACRYLIC CEMENT; CALCIUM PHOSPHATE CERAMIC; MOXIFLOXACIN;

AREA UNDER THE CURVE; ARTICLE; BIODEGRADABILITY; BONE MINERALIZATION; BONE REMODELING; BONE STRENGTH; CANCELLOUS BONE; CHRONIC OSTEOMYELITIS; COMPARATIVE STUDY; CONTROLLED STUDY; DRUG DELIVERY SYSTEM; ELUTION; ENTEROBACTERIACEAE; HIGH PERFORMANCE LIQUID CHROMATOGRAPHY; INCUBATOR; NONHUMAN; PRIORITY JOURNAL; ROOM TEMPERATURE; STAPHYLOCOCCUS; TEMPERATURE;

ABSORBABLE IMPLANTS; ANTI-BACTERIAL AGENTS; AZA COMPOUNDS; BONE CEMENTS; CALCIUM PHOSPHATES; CHROMATOGRAPHY, HIGH PRESSURE LIQUID; DRUG CARRIERS; MICROBIAL SENSITIVITY TESTS; OSTEOMYELITIS; QUINOLINES;

EID: 33747137237     PISSN: 09248579     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.ijantimicag.2006.05.024     Document Type: Article

References (14)

1. Zalavras C.G., Patzakis M.J., and Haulton P. Local antibiotic therapy in the treatment of open fractures and osteomyelitis. Clin Othop Relat Res 427 (2004) 86-93
2. Kanellakopoulou K., and Giamarellos-Bourboulis E.J. Carrier systems for the local delivery of antibiotics in bone infections. Drugs 59 (2000) 1223-1232
3. Simpson D., and Keating J.F. Outcome of tibial plateau fractures managed with calcium phosphate cement. Injury 35 (2004) 913-918
4. Dajcs J.J., Thibodeaux B.A., Marquart M.E., Girgis D.O., Traidej M., and O'Callaghan R.J. Effectiveness of ciprofloxacin, levofloxacin, or moxifloxacin for treatment of experimental Staphylococcus aureus keratitis. Antimicrob Agents Chemother 48 (2004) 1948-1952
5. Constantz B.R., Ison I.C., Fulmer M.T., et al. Skeletal repair by in situ formation of the mineral phase of bone. Science 267 (1995) 1796-1799
6. Kanellakopoulou K., Kolia M., Anastassiadis A., et al. Lactic acid polymers as biodegradable carriers of fluoroquinolones: an in vitro study. Antimicrob Agents Chemother 43 (1999) 714-716
7. Kraemer H.J., Gehrke R., and Breithaupt H. Simultaneous quantification of cefotaxime, desacetylcefotaxime, ofloxacine and ciprofloxacine by high-performance liquid chromatography. J Chromatogr B Biomed Sci Appl 700 (1997) 147-153
8. Wong F.A., Juzwin S.J., and Flor S.C. Rapid stereospecific high-performance chromatographic determination of levofloxacin in human plasma and urine. J Pharm Biomed Anal 15 (1997) 765-771
9. Clive B., Duncan P., and Masri B.A. The role of antibiotic loaded cement in the treatment of an infection after a hip replacement. J Bone Joint Surg Br 76A (1994) 1742-1751
10. Liu S.J., Ueng S.W.N., Lin S.S., and Chan E.C. In vivo release of vancomycin from biodegradable beads. J Biomed Mater Res 63 (2002) 807-813
11. Cerretani D., Giorgi G., Fornara P., et al. The in vitro elution characteristic of vancomycin combined with imipenem-cilastatin in acrylic bone-cements. J Arthroplasty 17 (2000) 619-626
12. Firsov A.A., Lubenko I.Y., Vostrov S.N., Portnoy Y.A., and Zinner S.H. Antistaphylococcal effect related to the area under the curve/MIC ratio in an in vitro dynamic model: predicted breakpoints versus clinically achievable values for seven fluoroquinolones. Antimicrob Agents Chemother 49 (2005) 2642-2647
13. Cassidy C., Jupiter J.B., Cohen M., et al. Norian SRS cement compared with conventional fixation in distal radial fractures. A randomized study. J Bone Joint Surg Am 85A (2003) 2127-2137
14. Zimmermann R., Gabl M., Lutz M., Angermann P., Gschwentner M., and Pechlaner S. Injectable calcium phosphate bone cement Norian SRS for the treatment of intra-articular compression fractures of the distal radius in osteoporotic women. Arch Orthop Trauma Surg 123 (2003) 22-27