Design and synthesis of an orally active matrix metalloproteinase inhibitor

Bioorganic and Medicinal Chemistry

Volumn 14, Issue 18, 2006, Pages 6383-6403

  Yamamoto, Shingo ^a   Nakatani, Shingo ^a   Ikura, Masahiro ^a   Sugiura, Tsuneyuki ^a   Nishita, Yoshitaka ^a   Itadani, Satoshi ^a   Ogawa, Koji ^a   Ohno, Hiroyuki ^a   Takahashi, Kanji ^a   Nakai, Hisao ^a   Toda, Masaaki ^a  

^a ONO PHARMACEUTICAL CO   (Japan)

Author keywords

Hydroxamate inhibitor; l Glutamic acid; Matrix metalloproteinase inhibitor; MMP

Indexed keywords

4 (4 PHENOXY)BENZOYLAMINO 4 METHOXYMETHYLOXYMETHYLBUTYRIC ACID HYDROXAMATE; GELATINASE A; GELATINASE B; GLUTAMIC ACID; HYDROXAMIC ACID DERIVATIVE; MATRIX METALLOPROTEINASE INHIBITOR; STROMELYSIN; UNCLASSIFIED DRUG;

ARTICLE; DRUG DESIGN; DRUG SYNTHESIS; STRUCTURE ACTIVITY RELATION;

ADMINISTRATION, ORAL; ANIMALS; BENZAMIDES; DRUG DESIGN; DRUG EVALUATION, PRECLINICAL; ENZYME ACTIVATION; GLUTAMIC ACID; GUINEA PIGS; HYDROXAMIC ACIDS; MALE; MATRIX METALLOPROTEINASES; MOLECULAR CONFORMATION; PROTEASE INHIBITORS; STEREOISOMERISM; STRUCTURE-ACTIVITY RELATIONSHIP;

EID: 33747130324     PISSN: 09680896     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.bmc.2006.05.040     Document Type: Article

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