Peptide-polyethylene glycol conjugates: Synthesis and properties of peptides bearing a C-terminal polyethylene glycol chain

Bioorganic and Medicinal Chemistry

Volumn 14, Issue 18, 2006, Pages 6197-6201

  Grun, Jessica ^a   Revell, Jefferson D ^a   Conza, Matteo ^a   Wennemers, Helma ^a  

^a UNIVERSITY OF BASEL   (Switzerland)

Author keywords

Asymmetric catalysis; Epimerization; Molecular recognition; Peptides; Polyethylene glycol

Indexed keywords

MACROGOL DERIVATIVE; PEPTIDE DERIVATIVE;

ARTICLE; CATALYSIS; PEPTIDE SYNTHESIS;

CATALYSIS; MOLECULAR STRUCTURE; PEPTIDES; POLYETHYLENE GLYCOLS; SOLUBILITY; SOLUTIONS;

EID: 33747099867     PISSN: 09680896     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.bmc.2006.05.079     Document Type: Article

References (16)

1. for example, see:. Roberts M.J., Bentley M.D., and Harris J.M. Adv. Drug Deliv. Rev. 54 (2002) 459-476
2. Veronese F.M. Biomaterials 22 (2001) 405-417
3. Krattiger P., Kovasy R., Revell J.D., Ivan S., and Wennemers H. Org. Lett. 7 (2005) 1101-1103
4. Krattiger P., Kovàsy R., Revell J.D., and Wennemers H. QSAR Comb. Sci. 24 (2005) 1158-1163
5. Revell J.D., Gantenbein D., Krattiger P., and Wennemers H. Biopolymers Pept. Sci. 84 (2006) 105-113
6. Wennemers H., Conza M., Nold M., and Krattiger P. Chem. Eur. J. 7 (2001) 3342-3347
7. Wennemers H., Nold M., Conza M., Kulicke K.J., and Neuburger M. Chem. Eur. J. 9 (2003) 442-448
8. Conza M., and Wennemers H. Chem. Commun. (2003) 866-867
9. Barlos K., Gatos D., Kallitsis J., Papaphotiu G., Sotiriu P., Wenqing Y., and Schäfer W. Tetrahedron Lett. 30 (1989) 3943-3946
10. Dombi K., Griesang N., and Richert C. Synthesis (2002) 816-824
11. n,PEO ≈ 73, respectively).
12. EDC = 1-(3-dimethylaminopropyl)-3-ethylcarbodiimide, HOBt = 1-hydroxybenzotriazole, HATU = O-(7-Azabenzotriazol-1-yl)-N,N,N′,N′-tetramethyluronium-hexafluorophosphate, TBTU = O-benzotriazol-1-yl-N,N,N′,N′-tetramethyluronium-tetrafluoroborate, DEPBT = 3-(Diethoxy-phosphoryloxy)-3H-benzo[d][1,2,3] triazin-4-one.
13. Li H., Jiang X., Ye Y., Fan C., Romoff T., and Goodman M. Org. Lett. 1 (1999) 91-93
14. Rapp Polymere, Tübingen (Germany).
15. Hudson D. J. Comb. Chem. 1 (1999) 403-457
16. Kaiser E., Colescott R.L., Bossinger C.D., and Cook P.I. Anal. Biochem. 34 (1970) 595-598