The paradoxical effects of splenectomy on tumor growth

Theoretical Biology and Medical Modelling

Volumn 3, Issue , 2006, Pages

  Prehn, Richmond T ^a  

^a UNIVERSITY OF WASHINGTON   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

CANCER GRAFT; CARCINOGENESIS; CLINICAL TRIAL; DIGESTIVE SYSTEM; HUMAN; IMMUNOGENICITY; INBRED STRAIN; MEDICAL LITERATURE; NONHUMAN; REVIEW; SPLEEN CELL; SPLENECTOMY; TUMOR CELL; TUMOR GROWTH; ANIMAL; C57BL MOUSE; CANCER TRANSPLANTATION; CELL DIVISION; DISEASE MODEL; IMMUNOLOGY; MOUSE; NEOPLASMS; PATHOLOGY; THYMECTOMY;

ANIMALIA;

ANIMALS; CELL DIVISION; DISEASE MODELS, ANIMAL; HUMANS; MICE; MICE, INBRED C57BL; NEOPLASM TRANSPLANTATION; NEOPLASMS; SPLENECTOMY; THYMECTOMY;

EID: 33747089986     PISSN: 17424682     EISSN: 17424682     Source Type: Journal    
DOI: 10.1186/1742-4682-3-23     Document Type: Review

References (38)

1. Mebius RE, Kraal G: Structure and function of the spleen. Nature Rev Immunol 2005, 5:606-616.
2. Prehn RT: The immune reaction as a stimulator of tumor growth. Science 1972, 176:170-171.
3. Prehn RT: Stimulatory effects of immune reactions upon the growth of untransplanted tumors. Cancer Res 1994, 54:908-914.
4. Rubin H: What keeps cells in tissues behaving normally in the face of myriad mutations? BioEssays 2006, 28:515-524.
5. Kumashiro R, Shiraishi M, Sugimachi K, Hiramoto Y, Tamada R, Okamura T, Masuda H, Inokuchi K, Nomoto K: Bidirectional effects of splenectomy on the growth of syngeneic tumor in mice. Jpn J Surg 1984, 14:167-173.
6. Nordlund JJ, Gershon RK: Splenic regulation of the clinical appearance of small tumors. J Immunol 1975, 114:1486-1490.
7. Chang RW, Turk JL: Increased resistance in splenectomized mice to a methylcholanthrene-induced tumour. Br J Cancer 1977, 35:768-776.
8. Prehn RT: Non-genetic variability in susceptibility to oncogenesis. Science 1975, 190:1095-1096.
9. Basombrio MA: Search for common antigenicities among twenty-five sarcomas induced by methylcholanthrene. Cancer Res 1970, 30:2458-2462.
10. Prehn RT: Immunological basis for differences insusceptibility to hydrocarbon oncogenesis among mice of a single genotype. Int J Cancer 1979, 24:789-791.
11. Prehn RT, Karcher CA: Splenic variations affecting sarcomagenesis among mice of an inbred strain. Int J Cancer 1983, 31:65-66.
12. Prehn RT: Cancers beget mutations versus mutations beget cancers. Cancer Res 1994, 54:5296-5300.
13. Kossoy G, Ben-Hur H, Lifschitz O, Zusman I: Mammary tumors in splenectomized rats. Oncol Rep 2002, 9:185-188.
14. Ben-Hur H, Kossoy G, Lifschitz O, Zusman I: Splenectomy, chemically-induced mammary tumors and parathymic lymph nodes in rats: experimental and morphological studies. In Vivo 2002, 16:275-280.
15. Stjernswärd J: Immune status of the primary host toward its own methylcholanthrene-induced sarcomas. J Natl Cancer Inst 1968, 40:113-22.
16. Basombrio MA, Prehn RT: Immune status of autochthonous and adoptively protected mice toward spontaneous and chemically induced tumors. Cancer Res 1972, 32:2545-2550.
17. Prehn RT: An adaptive immune reaction may be necessary for cancer development. Theor Biol Med Model 2006, 3:6.
18. Squartini F: Mouse mammary tumorigenesis by mammary tumor virus in the absence of thymus, spleen or both organs. Israel J Med Sci 1971, 7:26-35.
19. Mellemkjaer L, Olsen JH, Linet MS, Gridley G: Cancer risk after splenectomy. Cancer 1995, 75:577-583.
20. Linet MS, Nyren O, Gridley G, Mellemkjaer L, McLaughlin JK, Olsen JH, Adami HO, Fraumeni JF Jr: Risk of cancer following splenectomy. Int J Cancer 1996, 66:611-616.
21. Yamagishi H, Pellis NR, Kahan BD: Effect of splenectomy upon tumor growth: characterization of splenic tumor-enhancing cells in vivo. Surgery 1980, 87:655-661.
22. Hull CC, Galloway P, Gordon N, Gerson SL, Hawkins N, Stellato TA: Splenectomy and the induction of murine colon cancer. Arch Surg 1988, 123:462-464.
23. Larkin J, Tangney M, Collins C, Casey G, O'Brien MG, Soden D, O'Sullivan GC: Oral immune tolerance mediated by suppressor T cells may be responsible for the poorer prognosis of foregut cancers. Med Hypotheses 2005, 66:541-544.
24. Suh ED, Vistica BP, Chan CC, Raber JM, Gery I, Nussenblatt RB: Splenectomy abrogates the induction of oral tolerance in experimental autoimmune uveoretinitis. Curr Eye Res 1993, 12:833-839.
25. Sato N, Michaelides MC, Wallack MK: Effect of splenectomy on the growth of murine colon tumors. J Surg Oncol 1983, 22:73-76.
26. Ertuck S, Ersan Y, Cicek Y, Dogusoy G, Senocak M: Effect of simultaneous splenectomy on the survival of patients undergoing curative gastrectomy for proximal gastric carcinoma. Surg Today 2003, 33:254-258.
27. Fatouros M, Roukos DH, Lorenz M, Arampatzis I, Hottentrott C, Encke A, Kappas AM: Impact of spleen preservation in patients with gastric cancer. Anti Cancer Res 2005, 25:3023-30.
28. Fotiadis C, Zografos G, Aronis K, Troupis TG, Gorgoulis VG, Sechas MN, Skalkeas G: The effect of various types of splenectomy on the development of B-16 melanoma in mice. Int J Investig 1999, 1:113-20.
29. Stolfi RL, Stolfi LM, Fugmann RA, Martin DS: Augmented therapeutic results elicited by splenectomy in combined modality treatment of spontaneous murine breast cancer. Cancer Immunol Immunother 1977, 3:137-143.
30. Prehn RT, Main JM: Immunity to methylcholanthrene-induced sarcomas. J Natl Cancer Inst 1957, 18:769-778.
31. Itzhaki O, Skutelsky E, Kaptzan T, Sinai J, Michowitz M, Huszar M, Leibovici J: Ageing-apoptosis relation in murine spleen. Mech Ageing Dev 2003, 124:999-1012.
32. Donin N, Sinai J, Michowitz M, Hiss J, Nordenberg J, Leibovici J: Role of immune response as determinant of tumor progression in function of host age in the B16 melanoma. Mech Ageing Dev 1995, 80:121-37.
33. Donin N, Sinai J, Staroselsky A, Mahlin T, Nordenberg J, Leibovici J: Comparison of growth rate of two B16 melanomas differing in metastatic potential in young versus middle-aged mice. Cancer Invest 1997, 15:416-21.
34. Weitz J, D'Angelica M, Gonen M, Klimstra D, Coit DG, Brennan MF, Karpeh MS: Interaction of splenectomy and perioperative blood transfusions on prognosis of patients with proximal gastric and gastroesophageal junction cancer. J Clin Oncol 2003, 21:4597-4603.
35. Prehn RT: The immunity-inhibiting role of the spleen and the effect of dosage and route of antigen administration in a homograft reaction. In Colloque International sur les Problèmes biologiques des Greffes Université de Liege mars; 1959:163-173.
36. Michowitz M, Donin N, Sinai J, Leibovici J: Comparison of splenectomy effects as an indication for host response to growth of primary and metastatic tumour cells in two murine tumour systems. Int J Exp Pathol 1995, 76:13-19.
37. Leibovici J, Michowitz M, Argaman H: Change in the role of the spleen from protective to harmful following tumor progression in AKR lymphoma. Invasion Metastasis 1990, 10:289-300.
38. Tatematsu M, Lee G, Hayes MA, Farber E: Progression in hepatocarcinogenesis: Differences in growth and behavior of trans plants of early and late hepatocyte nodules in the rat spleen. Cancer Res 1987, 47:4699-4705.