Prophylactic aspirin therapy does not increase faecal calprotectin concentrations

European Journal of Gastroenterology and Hepatology

Volumn 18, Issue 9, 2006, Pages 965-967

  Montalto, Massimo ^a   Curigliano, Valentina ^a   Santoro, Luca ^a   Lombardi, Mariaelena ^a   Covino, Marcello ^a   Cammarota, Giovanni ^a   Dalvai, Sara ^a   D'Onofrio, Ferruccio ^a   Gasbarrini, Antonio ^a   Gasbarrini, Giovanni ^a  

^a CATHOLIC UNIVERSITY   (Italy)

Author keywords

Aspirin; Enteropathy; Faecal calprotectin; Intestinal inflammation; Non steroidal anti inflammatory drugs

Indexed keywords

ACETYLSALICYLIC ACID; CALPROTECTIN;

ADULT; ARTICLE; CLINICAL ARTICLE; CLINICAL TRIAL; CONTROLLED CLINICAL TRIAL; CONTROLLED STUDY; ENZYME LINKED IMMUNOSORBENT ASSAY; FECES ANALYSIS; FEMALE; HUMAN; HUMAN TISSUE; LOW DRUG DOSE; MALE; PILOT STUDY; PRIORITY JOURNAL; PROPHYLAXIS; STATISTICAL ANALYSIS; STUDENT T TEST;

ANTI-INFLAMMATORY AGENTS, NON-STEROIDAL; ASPIRIN; BIOLOGICAL MARKERS; CAROTID ARTERY DISEASES; CASE-CONTROL STUDIES; ENTERITIS; FECES; FEMALE; HUMANS; LEUKOCYTE L1 ANTIGEN COMPLEX; MALE; MIDDLE AGED; PILOT PROJECTS;

EID: 33747035258     PISSN: 0954691X     EISSN: None     Source Type: Journal    
DOI: 10.1097/01.meg.0000230080.59135.e1     Document Type: Article

References (14)

1. Bjarnason I, Hayllar J, Mac Pherson AJ, Russel AS. Side effects of nonsteroidal anti-inflammatory drugs on the small and large intestine in humans. Gastroenterology 1993; 104:1832-1847.
2. Sigthorsson G, Tibble J, Hayllar J, Menzies I, Macpherson A, Moots R, et al. Intestinal permeability and inflammation in patients on NSAIDs. Gut 1998; 43:506-511.
3. Adebayo D, Bjarnason I. Is non-steroidal anti-inflammaory drug (NSAID) enteropathy clinically more important than NSAID gastropathy? Postgrad Med J 2006; 82:186-191.
4. Maiden L, Thjodleifsson B, Theodors A, Gonzalez J, Bjarnason I. A quantitative analysis of NSAID-induced small bowel pathology by capsule enteroscopy. Gastroenterology 2005; 128:1172-1178.
5. Bjarnason I, MacPherson A, Hollander D. Intestinal permeability: an overview. Gastroenterology 1995; 108:1566-1581.
6. Tibble JA, Sigthorsson G, Foster R, Scott D, Fagerhol MK, Roseth A, et al. High prevalence of NSAID enteropathy as shown by a simple faecal test. Gut 1999; 45:362-366.
7. Smecuol E, Bai JC, Sugai E, Vazquez H, Niveloni S, Pedreira S, et al. Acute gastrointestinal permeability responses to different non-steroidal anti-inflammatory drugs. Gut 2001; 49:650-655.
8. Bjarnason I, Fehilly B, Smethurst P, Menzies IS, Levi AJ. Effects of nonsteroidal antiinflammatory drugs on permeability of the small intestine in humans. J Rheumatol Suppl 1992; 36:83-84.
9. Montalto M, Maggiano N, Ricci R, Curigliano V, Santoro L, Di Nicuolo F, et al. Lactobacillus acidophilus protects tight junctions from aspirin damage in HT-29 cells. Digestion 2004; 69:225-228.
10. Lanza FL. A review of mucosal protection by synthetic prostaglandin E analogs against injury by non-steroidal anti-inflammatory agents. Scand J Gastroenterol Suppl 1989; 163:36-43.
11. Bjarnason I, Fehilly B, Smethurst P, Menzies IS, Levi AJ. Importance of local versus systemic effects of non-steroidal anti-inflammatory drugs in increasing small intestinal permeability in man. Gut 1991; 32:275-277.
12. Brune K, Dietzel K, Nurnberg B, Schneider HT. Recent insight into the mechanism of gastrointestinal tract ulceration. Scand J Rheumatol Suppl 1987; 65:135-140.
13. Melarange R, Gentry C, O'Connell C, Blower PR, Neil C, Kelvin AS, et al. Antiinflammatory and gastrointestinal effects of nabumetone or its active metabolite, 6-methoxy-2-naphthylacetic acid (6MNA). Comparative studies with indomethacin. Dig Dis Sci 1992; 37:1847-1852.
14. Somasundaram S, Rafi S, Hayllar J, Sigthorsson G, Jacob M, Price AB, et al. Mitochondrial damage: a possible mechanism of the "topical" phase of NSAID induced injury to the rat intestine. Gut 1997; 41:344-353.