Runx2 expression is associated with pathologic new bone formation around radicular cysts: An immunohistochemical demonstration

Journal of Oral Pathology and Medicine

Volumn 35, Issue 8, 2006, Pages 492-499

  Kusafuka, Kimihide ^a,b   Sasaguri, Kenichi ^c   Sato, Sadao ^c   Takemura, Tamiko ^b   Kameya, Toru ^a  

^a SHIZUOKA CANCER CENTER   (Japan)

^b JAPANESE RED CROSS MEDICAL CENTER   (Japan)

^c KANAGAWA DENTAL COLLEGE   (Japan)

Author keywords

Immunohistochemistry; New bone formation; Radicular cyst; Runx2(cbfa1 pebp2 A AML3 ); Transforming growth factor

Indexed keywords

ANTISERUM; COLLAGEN FIBER; COLLAGEN TYPE 1; DNA BINDING PROTEIN; TRANSCRIPTION FACTOR RUNX2; TRANSFORMING GROWTH FACTOR BETA1; TRANSFORMING GROWTH FACTOR BETA2;

ADULT; AGED; ALVEOLAR BONE; ANIMAL CELL; ANTIBODY SPECIFICITY; ARTICLE; B LYMPHOCYTE; BONE REMODELING; CELL MEMBRANE; CELL NUCLEUS; CELL SHAPE; CLINICAL ARTICLE; COLLAGEN SYNTHESIS; CONTROLLED STUDY; FEMALE; HUMAN; HUMAN CELL; HUMAN TISSUE; IMMUNOHISTOCHEMISTRY; IMMUNOLOCALIZATION; INFLAMMATORY INFILTRATE; JAW CYST; MALE; MOUSE; NONHUMAN; ODONTOGENIC CYST; OSSIFICATION; OSTEOBLAST; OSTEOCYTE; PATHOLOGY; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEIN LOCALIZATION; SIGNAL TRANSDUCTION; SPINDLE CELL; STEM CELL; WESTERN BLOTTING;

ACTIVIN RECEPTORS, TYPE I; ANIMALS; ANTIGENS, CD20; ANTIGENS, CD31; ANTIGENS, CD45; BONE REMODELING; COLLAGEN TYPE I; CORE BINDING FACTOR ALPHA 1 SUBUNIT; FEMALE; HUMANS; MALE; MICE; MIDDLE AGED; OSSIFICATION, HETEROTOPIC; RADICULAR CYST; RECEPTORS, TRANSFORMING GROWTH FACTOR BETA;

EID: 33747033901     PISSN: 09042512     EISSN: 16000714     Source Type: Journal    
DOI: 10.1111/j.1600-0714.2006.00426.x     Document Type: Article

References (24)

1. Shafer WG, Hine MK, Levy BM. A textbook of oral pathology, 4th edn. Apical periodontal cyst. Tokyo/Philadelphia: Igaku-Shoin/Saunders, 1983; 493-8.
2. Linsenmayer TF. Collagen. In: Hay ED ed. Cell biology of extracellular matrix, 2nd edn. New York, USA: Plenum, 1991; 7-44.
3. Sandberg MN, Aro HT, Viorio EI. Gene expression during bone repair. Clin Orthop 1993; 286: 292-312.
4. Kania MA, Bonner AS, Duffy JB, Gergen JP. The Drosophila segmentation gene runt encodes a novel nuclear regulatory protein that is also expressed in the developing nervous system. Genes Dev 1990; 4: 1701-13.
5. Miura Y, Fitzsimmon JS, Commisso CN, Gally SH, O'Driscoll SW. Enhancement of periosteal chondrogenesis in vitro: high-response for transforming growth factor-beta1 (TGFβ1). Clin Orthop 1994; 301: 271-80.
6. Komori T, Yagi H, Nomura S, et al. Targeted disruption of Cbfa1 results in complete lack of bone formation owing to maturation arrest of osteoblasts. Cell 1997; 89: 755-64.
7. Zhang YW, Yasui N, Ito K, et al. A RUNX2/PEBP2αA/ CBFA1 mutation displaying impaired transactivation and Smad interaction in cleidocranial dysplasia. Proc Natl Acad Sci U S A 2000; 97: 10549-54.
8. Kusafuka K, Yamaguchi A, Kayano T, Takemura T. Immunohistochemical localization of members of the transforming growth factors (TGF)-β superfamily in normal human salivary glands and pleomorphic adenomas. J Oral Pathol Med 2001; 30: 413-20.
9. Bae SC, Takahashi E, Zhang YW, et al. Cloning, mapping and expression of PEBP2αC, a third gene encoding the mammalian Runt domain. Gene 1995; 159: 245-8.
10. Geoffroy M, Ducy P, Karsenty G. A PEBP2α/AML-1-related factor increases osteocalcin promoter activity through its binding to an osteoblast-specific cis-acting element. J Biol Chem 1995; 240: 30973-9.
11. Merriman HL, van Wijnen AJ, Hiebert S, et al. The tissue-specific nuclear matrix protein, NMP-2, is a member of the AML/CBF/PEBP2/Runt domain transcription factor family: interaction with the osteocalcin gene promoter. Biochemistry 1995; 34: 13125-32.
12. Benerjee C, Hiebert SW, Stein JL, Lian JB, Stein GS. An AML-1 consensus sequence binds an osteoblast-specific complex and transcriptionally activates the osteocalcin gene. Proc Natl Acad Sci U S A 1996; 93: 4968-73.
13. Ducy P, Zhang R, Geoffroy V, Ridall AL, Karsentry G. Osf2/cbfa1: a transcriptional activator of osteoblast differentiation. Cell 1997; 89: 747-54.
14. Harada H, Tagashira S, Fujiwara M, et al. Cbfa1 isoforms exert functional differences in osteoblast differentiation. J Biol Chem 1999; 274: 6972-8.
15. Banerjee C, McCabe LR, Choi JY, et al. Runt homology domain proteins in osteoblast differentiation: AML3/ CBFA1 in major component of a bone-specific complex. J Cell Biochem 1997; 66: 1-8.
16. Broncker AL, Sasaguri K, Cavender AC, D'Souza RN, Engelse MA. Expression of Runx2/ Cbfa1.Pebp2alphaA during angiogenesis in postnatal rodent and fetal human orofacial tissues. J Bone Miner Res 2005; 3: 427-37.
17. Ogawa E, Matsuyama M, Kagoshima H, et al. PEBP2/ PEA2 represents A new family of transcription factor homologous to the products of the Drosophila runt and the human AML-1 gene. Proc Natl Acad Sci USA 1993; 90: 6859-63.
18. Satake M, Nomura S, Yamaguchi-Iwai Y, et al. Expression of the runt domain-encoding PEBP2α genes in T cells during thymic development. Mol Cell Biol 1995; 5: 1662-70.
19. Quaglino D, Nannoy LB, Kennedy R, Davidson JM. Transforming growth factor-β stimulates wound healing and modulates extracellular matrix gene expression in pig skin: I. Excisional wound model. Lab Invest 1990; 63: 307-19.
20. Truong LD, Kadman DOV, McCune BK, Flanders KC, Scandino PT, Thompson TC. Association of transforming growth factor-β1 with prostatic cancer: an immunohistochemical study. Hum Pathol 1993; 23: 4-9.
21. Miura Y, Fitzsimmon JS, Commisso CN, Gally SH, O'Driscoll SW. Enhancement of peritoneal chondrogenesis in vitro: high-response for transforming growth factor-beta1 (TGFβ1). Clin Orthop 1994; 301: 271-80.
22. Minami S, Nerbst H, Schuppen D, Stein H, Surrenti C. Transforming growth factor β1 and β2 are differentially expressed in fibrotic liver disease. Am J Pathol 1991; 139: 1221-9.
23. Massague J. The transforming growth factor-β family. Annu Rev Cell Biol 1990; 6: 597-641.
24. Kerhl JA, Wakefirld LM, Robert AB, et al. Production of transforming growth factor β by human T lymphocytes and its potential role in the regulation of T cell growth. J Exp Med 1986; 163: 1037-50.