Synthesis and properties of a neutral derivative of diethylenetriaminepentaacetic acid (DTPA)

Bioorganic and Medicinal Chemistry Letters

Volumn 16, Issue 18, 2006, Pages 4760-4762

  Peuralahti, Jari ^a   Meriö, Liisa ^a   Mukkala, Veli Matti ^a   Blomberg, Kaj ^a   Hovinen, Jari ^a  

^a PerkinElmer Finland Oy   (Finland)

Author keywords

DELFIA; DTPA; Europium; Imaging

Indexed keywords

PENTETIC ACID;

ARTICLE; CHELATION; DISSOCIATION; DRUG SYNTHESIS; FLUORESCENCE SPECTROSCOPY; IMMUNOASSAY; NUCLEAR MAGNETIC RESONANCE IMAGING; SINGLE PHOTON EMISSION COMPUTER TOMOGRAPHY;

IMMUNOASSAY; MOLECULAR STRUCTURE; PENTETIC ACID;

EID: 33746994077     PISSN: 0960894X     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.bmcl.2006.06.088     Document Type: Article

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23. 2V).
24. Compound 14 was synthesized by allowing l-thyroxine to react with Fmoc-aminohexanoic acid N-hydroxysuccinate (1.1 equiv) in dry DMF in dark (1 h at rt). Piperidine was then added (removal of Fmoc group), and the reaction was allowed to proceed for 30 min at rt before being concentrated in vacuo. The title compound was obtained by precipitation from methanol.