Characterization of a microparticulate strong anion-exchange in the HPLC of acidic drugs

Biomedical Chromatography

Volumn 20, Issue 8, 2006, Pages 765-773

  Morgan, Phillip E ^a   Hanna Brown, M ^b   Flanagan, R J ^a  

^a GUY'S AND ST THOMAS' NHS FOUNDATION TRUST   (United Kingdom)

^b KING'S COLLEGE LONDON   (United Kingdom)

Author keywords

Acidic compounds; Anion exchange HPLC; NSAIDs; SAX

Indexed keywords

HYDROPHOBICITY; INORGANIC COMPOUNDS; ION EXCHANGE; IONIC STRENGTH; IONIZATION OF LIQUIDS;

ACIDIC COMPOUNDS; ANALYTES; ANION EXCHANGE; ANION-EXCHANGE HPLC; COUNTERIONS; ELUENTS; MICROPARTICULATES; NON-STEROIDAL ANTI-INFLAMMATORY DRUGS; PH VALUE; STRONG ANION EXCHANGES;

PH;

4 AMINOPHENOL; 4 CHLOROBENZOIC ACID; 4 NITROPHENOL; ACETYLSALICYLIC ACID; ALCLOFENAC; AMMONIA; FENBUFEN; FENOPROFEN; HYDROCHLORIC ACID; IBUPROFEN; INDOMETACIN; MEFENAMIC ACID; METHANOL; NAPROXEN; NONSTEROID ANTIINFLAMMATORY AGENT; PERCHLORATE; PHENOLPHTHALEIN; PHENYLBUTAZONE; SALICYLIC ACID; SULINDAC; TIAPROFENIC ACID; WARFARIN; WATER;

ACIDITY; ANION EXCHANGE; ARTICLE; CHEMICAL BOND; CHEMICAL INTERACTION; CONTROLLED STUDY; DRUG STRUCTURE; HIGH PERFORMANCE LIQUID CHROMATOGRAPHY; HYDROPHOBICITY; ION EXCHANGE; IONIC STRENGTH; IONIZATION; PH; SEPARATION TECHNIQUE; SOLVATION; TIME;

EID: 33746986475     PISSN: 02693879     EISSN: 10990801     Source Type: Journal    
DOI: 10.1002/bmc.595     Document Type: Article

References (14)

1. Bidlingmeyer BA, Del Rios JK and Korpi J. Separation of organic amine compounds on silica gel with reversed-phase eluents. Analytical Chemistry 1982; 54: 442-447.
2. Carlucci G, Mazzeo P and Palumbo G. Simultaneous determination of rufloxacin, fenbufen and felbinac in human plasma using high-performance liquid chromatography. Journal of Chromatography B 1996; 682: 315-319.
3. Cox GB and Stout RW. Study of the retention mechanisms for basic compounds on silica under 'pseudo-reversed-phase' conditions. Journal of Chromatography 1987; 384: 315-336.
4. Croes K, McCarthy PT and Flanagan RJ. Simple and rapid HPLC of quinine, hydroxychloroquine, chloroquine, and desethylchloroquine in serum, whole blood, and filter paper-adsorbed dry blood. Journal of Analytical Toxicology 1994; 18: 255-260.
5. Croes K, McCarthy PT and Flanagan RJ. HPLC of basic drugs and quaternary ammonium compounds on microparticulate strong cation-exchange materials using methanolic or aqueous methanol eluents containing an ionic modifier. Journal of Chromatography A 1995; 693: 289-306.
6. Flanagan RJ and Jane I. High-performance liquid chromatographic analysis of basic drugs on silica columns using non-aqueous ionic eluents 1. Factors influencing retention, peak shape and detector response. Journal of Chromatography 1985; 323: 173-189.
7. Flanagan RJ, Storey GCA, Jane I and Bhamra RK. High-performance liquid chromatographic analysis of basic drugs on silica columns using non-aqueous ionic eluents. Journal of Chromatography 1982; 247: 15-37.
8. Law B. Analysis of basic compounds on a silica column with an aqueous methanol eluent. The use of quantitative structure-retention relationships in metabolite identification. Journal of Chromatography 1987; 407: 1-18.
9. Law B and Hussain MA. Re-evaluation of anion-exchange HPLC for the analysis of acidic compounds. Journal of Pharmaceutical and Biomedical Analysis 2000; 22: 149-154.
10. Li J, Milne RW, Nation RL, Turnidge JD and Coulthard K. Stability of colistin and colistin methanesulfonate in aqueous media and plasma as determined by high-performance liquid chromatography. Antimicrobial Agents and Chemotherapy 2003; 47: 1364-1370.
11. a in Chromatographic Method Development. ACD/Labs 5th Annual European Users' Meeting and 1st Annual PhysChem Symposium. Early ADME and Medicinal Chemistry: Obernai, 2004.
12. Nawrocki J. The silanol group and its role in liquid chromatography. Journal of Chromatography A 1997; 779: 29-71.
13. Sewell PA and Clarke B. Chromatographic Separations. Wiley: Chichester, 1987.
14. Yoshitake A, Kawahara K, Shono F, Umeda I, Izawa A and Komatsu T. Determination of miloxacin and metabolites in human serum and urine by high-pressure liquid chromatography. Antimicrobial Agents and Chemotherapy 1980; 18: 45-49.