Synthesis of derivatives of pyrido[4,3-d]pyrimidin-4(3H)-one via an iminophosphorane

Helvetica Chimica Acta

Volumn 89, Issue 7, 2006, Pages 1337-1343

  Liu, Jian Chao ^a   He, Hong Wu ^a   Ren, Qing Yun ^a   Ding, Ming Wu ^a  

^a CENTRAL CHINA NORMAL UNIVERSITY   (China)

Author keywords

[No Author keywords available]

Indexed keywords

AMINES; CATALYSIS; INFRARED SPECTROSCOPY; MASS SPECTROMETERS; NUCLEAR MAGNETIC RESONANCE; PHENOLS; SUBSTITUTION REACTIONS; SYNTHESIS (CHEMICAL); X RAY DIFFRACTION ANALYSIS;

AZA-WITTIG REACTION; IMINOPHOSPHORANE; PHENYL ISOCYANATE;

DERIVATIVES;

2 (BUTYLAMINO) 3 (4 CHLOROPHENYL) 8,9,10,11 TETRAHYDRO 5 METHYL[1]BENZOTHIENO[3',2':5,6]PYRIDO[4,3 D]PYRIMIDIN 4(3H) ONE; 2 (BUTYLAMNO) 8,9,10,11 TETRAHYDRO 5 METHYL 3 PHENYL[1]BENZOTHIENO[3',2':5,6]PYRIDO[4,3 D]PYRIMIDIN 4(3H) ONE; 2 (DIBUTYLAMINO) 8,9,10,11 TETRAHYDRO 5 METHYL 3 PHENYL[1]BENZOTHIENO[3',2':5,6]PYRIDO[4,3 D]PYRIMIDIN 4(3H) ONE; 2 (DIETHYLAMINO) 8,9,10,11 TETRAHYDRO 5 METHYL 3 PHENYL[1]BENZOTHIENO[3',2':5,6]PYRIDO[4,3 D]PYRIMIDIN 4(3H) ONE; 2 (DIPROPYLAMINO) 8,9,10,11 TETRAHYDRO 5 METHYL 3 PHENYL[1]BENZOTHIENO[3',2':5,6]PYRIDO[4,3 D]PYRIMIDIN 4(3H) ONE; 2 [(1,1 DIMETHYLETHYL)AMINO] 8,9,10,11 TETRAHYDRO 5 METHYL 3 PHENYL[1]BENZOTHIENO[3',2':5,6]PYRIDO[4,3 D]PYRIMIDIN 4(3H) ONE; 2 [(2,2 DIMETHYLPROPYL)AMINO] 8,9,10,11 TETRAHYDRO 5 METHYL 3 PHENYL[1]BENZOTHIENO[3',2':5,6]PYRIDO[4,3 D]PYRIMIDIN 4(3H) ONE; 2 [(4 CHLOROPHENYL)OXY] 8,9,10,11 TETRAHYDRO 5 METHYL 3 PHENYL[1]BENZOTHIENO[3',2':5,6]PYRIDO[4,3 D]PYRIMIDIN 4(3H) ONE; 2 [(FURAN 2 YLMETHYL)AMINO] 8,9,10,11 TETRAHYDRO 5 METHYL 3 PHENYL[1]BENZOTHIENO[3',2':5,6]PYRIDO[4,3 D]PYRIMIDIN 4(3H) ONE; 2 ETHOXY 8,9,10,11 TETRAHYDRO 5 METHYL 3 PHENYL[1]BENZOTHIENO[3',2':5,6]PYRIDO[4,3 D]PYRIMIDIN 4(3H) ONE; 3 (4 CHLOROPHENYL) 8,9,10,11 TETRAHYDRO 5 METHYL 2[(1METHYLETHYL)AMINO][1]BENZOTHIENO[3',2':5,6]PYRIDO[4,3 D]PYRIMIDIN 4(3H) ONE; 3 (4 CHLOROPHENYL) 8,9,10,11 TETRAHYDRO 5 METHYL 3 PHENYL[1]BENZOTHIENO[3',2':5,6]PYRIDO[4,3 D]PYRIMIDIN 4(3H) ONE; 8,9,10,11 TETRAHYDRO 5 METHYL 2 [(1 METHYLETHYL)AMINO]3 PHENYL [1]BENZOTHIENO[3',2':5,6]PYRID[4,3 D]PYRIMIDIN 4(3H) ONE; 8,9,10,11 TETRAHYDRO 5 METHYL 2 [(1 METHYLPROPYL)AMINO]3 PHENYL [1]BENZOTHIENO[3',2':5,6]PYRID[4,3 D]PYRIMIDIN 4(3H) ONE; 8,9,10,11 TETRAHYDRO 5 METHYL 2 PHENOXY 3 PHENYL[1]BENZOTHIENO[3',2':5,6]PYRIDO[4,3 D]PYRIMIDIN 4(3H) ONE; 8,9,10,11 TETRAHYDRO 5 METHYL 3 PHENYL 2 (PROPYLAMINO)[1]BENZOTHIENO[3',2':5,6]PYRID[4,3 D]PYRIMIDIN 3(3H) ONE; 8,9,10,11 TETRAHYDRO 5 METHYL 3 PHENYL 2 PIPERIDIN 1 YL[1]BENZOTHIENO[3',2':5,6]PYRIDO[4,3 D]PYRIMIDIN 4(3H) ONE; AMINE; ANTINEOPLASTIC AGENT; CYANAMIDE; IMINOPHOSPHORANE; KETONE DERIVATIVE; PHENOL DERIVATIVE; PHENYL ISOCYANATE; PHOSPHORANE DERIVATIVE; PYRIDOL [4,3 D]PYRIMIDIN 4(3H) ONE; UNCLASSIFIED DRUG;

ARTICLE; CRYSTAL STRUCTURE; DRUG DESIGN; DRUG SYNTHESIS; INFRARED SPECTROSCOPY; NUCLEAR MAGNETIC RESONANCE; PRIORITY JOURNAL; STRUCTURE ANALYSIS; X RAY CRYSTALLOGRAPHY; X RAY DIFFRACTION;

EID: 33746903164     PISSN: 0018019X     EISSN: None     Source Type: Journal    
DOI: 10.1002/hlca.200690133     Document Type: Article

References (11)

1. G. W. Rewcastle, B. D. Palmer, A. M. Thompson, A. J. Bridges, J. Med. Chem. 1996, 39, 1823.
2. J. B. Smail, B. D. Palmer, G. W. Rewcastle, J. Med. Chem. 1999, 42, 1803.
3. P. Bhuyan, R. C. Boruah, J. S. Sandhu, J. Org. Chem. 1990, 55, 568.
4. M. Kajino, K. Meguro, Heterocycles 1990, 31, 2153.
5. R. S. Hosmane, B. B. Lim, M. F. Summers, N. S. Hosmane, J. Org. Chem. 1988, 53, 5309.
6. C. Bonini, M. D. Auria, M. Funicello, G. Romaniello, Tetrahedron 2002, 58, 3507.
7. M. W. Ding, S. J. Yang, J. Zhu, Synthesis 2004, 75.
8. A. C. Veronese, R. Callegari, C. F. Morelli. Tetrahedron 1995, 51, 12277.
9. M. W. Ding, S. Z. Xu, J. F. Zhao. J. Org. Chem. 2004, 69, 8366.
10. H. Wamhoff, S. Herrmann, S. Stolhern, Tetrahedron 1993, 49, 581.
11. C. K. Johnson, 'ORTEP-II. Report ORNL-5138', 1976.