Single-cell cloning of human, donor-derived antileukemia T-cell lines for in vitro separation of graft-versus-leukemia effect from graft-versus-host reaction

Cancer Research

Volumn 66, Issue 14, 2006, Pages 7310-7316

  Montagna, Daniela ^a,b   Daudt, Liane ^b   Locatelli, Franco ^b   Montini, Enrica ^b   Turin, Ilaria ^b   Lisini, Daniela ^b   Giorgiani, Giovanna ^b   Bernardo, Maria Ester ^b   Maccario, Rita ^b  

^a UNIVERSITY OF PAVIA   (Italy)

^b FONDAZIONE IRCCS POLICLINICO SAN MATTEO   (Italy)

Author keywords

[No Author keywords available]

Indexed keywords

CD4 ANTIGEN; CD8 ANTIGEN; GAMMA INTERFERON; INTERLEUKIN 2; T LYMPHOCYTE RECEPTOR;

ALLOIMMUNITY; ARTICLE; CELL CLONING; CELL LINE; CELL SEPARATION; CLINICAL ARTICLE; CONTROLLED STUDY; CYTOTOXICITY; FEMALE; GRAFT VERSUS HOST REACTION; GRAFT VERSUS LEUKEMIA EFFECT; HEMATOPOIETIC STEM CELL TRANSPLANTATION; HLA SYSTEM; HUMAN; HUMAN CELL; HUMAN TISSUE; IN VITRO STUDY; LEUKEMIA; LEUKEMIA CELL; MALE; PHENOTYPE; PRIORITY JOURNAL; PROTEIN EXPRESSION; T LYMPHOCYTE;

ACUTE DISEASE; ADOLESCENT; ADULT; CHILD; CHILD, PRESCHOOL; CLONE CELLS; FEMALE; GRAFT VS HOST REACTION; GRAFT VS LEUKEMIA EFFECT; HEMATOPOIETIC STEM CELL TRANSPLANTATION; HLA ANTIGENS; HUMANS; LEUKEMIA, LYMPHOCYTIC, ACUTE, L1; LEUKEMIA, MYELOID; MALE; T-LYMPHOCYTES, CYTOTOXIC;

EID: 33746900364     PISSN: 00085472     EISSN: None     Source Type: Journal    
DOI: 10.1158/0008-5472.CAN-06-0591     Document Type: Article

References (25)

1. Appelbaum FR. The current status of hematopoietic cell transplantation. Annu Rev Med 2003;51:491-512.
2. Barrett AJ, Horowitz MM, Pollock BH, et al. Bone Marrow transplant from HLA-identical siblings as compared with chemotherapy for children with acute lymphohlastic leukemia in a second remission. N Engl J Med 1994;331:1253-9.
3. Horowitz MM, Gale RP, Sondel PM, et al. Graft-versus-leukemia reaction after bone marrow transplantation. Blood 1990;78:2120-30.
4. Aversa F, Tabilio A, Velardi A, et al. Treatment of high-risk acute leukaemia with T-cell-depleted stem cells from related donors with one fully mismatched HLA haplotype. N Fngl J Med 1998;17:1186-93.
5. Parkman R, Weinberg KJ. Immunological reconstitution following bone marrow transplantation. Immunol Rev 1997;157:73-8.
6. Marmont AM, Horowitz MM, Gale RP, et al. T-cell depletion of HLA-identical transplants in leukemia. Blood 1991;78:2120-30.
7. Kolb HJ, Schmid C, Barrett AJ, Schendel DJ. Graft-versus-leukemia reactions in allogeneic chimeras. Blood 2004;103:767-76.
8. Ruggeri L, Capanni M, Urbani E, et al. Effectiveness of donor Natural Killer cell alloreactivity in mismatched haematopoietic transplants. Science 2002;295:2097-100.
9. Farag SS, Fehniger TA, Ruggeri L, Velardi A, Caligiuri MA. Natural killer cell receptors: new biology and insights into the graft-versus-leukemia effect. Blood 2002;100:1935-47.
10. Kolb HJ, Schattenberg A, Goldman JM, et al. Graft-versus-leukemia effect of donor lymphocyte transfusions in marrow grafted patients. Blood 1995;86:2041-50.
11. Collins RHJ, Shpilberg O, Drobyski WR, et al. Donor leukocyte infusions in 140 patients with relapsed malignancy after allogeneic bone marrow transplantation. J Clin Oncol 1997;15:433-44.
12. Montagna ID, Maccario R, Locatelli F, et al. Ex vivo priming for long-term maintenance of antileukemia human cytotoxic T cells suggests a general procedure for adoptive immunotherapy. Blood 2001;98:3359-66.
13. Montagna D, Maccario K, Montini F, et al. Generation and ex vivo expansion of cytotoxic T lymphocytes directed toward different types of leukaemia or myelodisplastic cells using both HLA-matched and partially matched donors. Exp Hematol 2003;31:1031-8.
14. Montagna D, Locatelli F, Calcaterra V, et al. Does the emergence and persistence of donor-derived leukaemia-reactive T lymphocytes protect patients given an allogeneic BMT from recurrence? Results of a preliminary study. Bone Marrow Transplant 1998;22:743-50.
15. +/CD28 cytotoxic T cell clones specific for leukemic blasts in children with acute leucemia. Cancer Res 1995;55:3935-9.
16. Montagna D, Schiavo R, Gibelli N, et al. Ex vivo generation and expansion of anti-tumor cytotoxic T-cell lines derived from patients or their HLA-identical sibling. Int J Cancer 2004;110:76-86.
17. Rukavina D, Balen-Marunic S, Rubesa G, Orlic P, Vuajaklija K, Podack ER. Perforin expression in peripheral blood lymphocytes in rejecting and tolerant kidney transplant recipients. Transplantation 1996;61:285-91.
18. Avanzini MA, Belloni C, De Silvestri A, et al. Antigen-specific T cell response in infants after recombinant hepatitis B virus vaccination at birth: evaluation of T helper lymphocyte diversity. Clin Immunol 2003;107:122-8.
19. Sallusto F, Geginat J, Lanzavecchia A. Central memory and effector memory T cell subset: function, generation and maintenance. Annu Rev Immunol 2004;22:745-63.
20. Marijt WAE, Heemskerk MHM, Kloosterhoer FM, et al. Hematopoiesis- restricted minor histocompatibility antigens HA-1- or HA-2-specific T cells can induce complete remission of relapsed leukaemia. Proc Natl Acad Sci U S A 2003;100:2742-7.
21. Falkenburg JHF, Smit WM, Willemze K. Cytotoxic T-lymphocyte (CTL) responses against acute or chronic myeloid leukaemia. Immunol Rev 1997;157:223-30.
22. + cell responses on antitumor immunity. Curr Opin Immunol 1998;10:588-94.
23. + T cell-dependent antitumor immunity by TAT-mediated tumor antigen delivery into dendritic cells. J Clin Invest 2002;109:1463-70.
24. + T lymphocytes from cancer patients are required for optimal induction of cytotoxic T cells against tumor. J Immunol 2000;164:3902-12.
25. Lanzavecchia A, Sallusto F. Dynamics of T lymphocyte response: intermediates, effector and memory cells. Science 2000;290:92-7.