Effects of repeated milnacipran administration on brain serotonergic and noradrenergic functions in healthy volunteers

Psychopharmacology

Volumn 187, Issue 4, 2006, Pages 526-527

  Soya, Atsushi ^a   Terao, Takeshi ^b   Nakajima, Mami ^c   Kojima, Hideki ^a   Okamoto, Tatsuya ^a   Inoue, Yoshiaki ^a   Iwakawa, Miki ^a   Shinkai, Koji ^a   Yoshimura, Reiji ^a   Ueta, Yoichi ^a   Nakamura, Jun ^a  

^a UNIVERSITY OF OCCUPATIONAL AND ENVIRONMENTAL HEALTH   (Japan)

^b OITA UNIVERSITY   (Japan)

^c Komine Eto Hospital   (Japan)

Author keywords

[No Author keywords available]

Indexed keywords

4 HYDROXY 3 METHOXYPHENYLETHYLENE GLYCOL; MILNACIPRAN; NORADRENALIN; PLACEBO; SEROTONIN; SEROTONIN UPTAKE INHIBITOR;

ADULT; ANALYSIS OF VARIANCE; CLINICAL TRIAL; CONTROLLED CLINICAL TRIAL; CONTROLLED STUDY; DOUBLE BLIND PROCEDURE; DRUG EFFECT; DRUG MECHANISM; HIGH PERFORMANCE LIQUID CHROMATOGRAPHY; HUMAN; HUMAN EXPERIMENT; INFORMED CONSENT; LETTER; MALE; NORADRENALIN BLOOD LEVEL; NORADRENERGIC SYSTEM; NORMAL HUMAN; PRIORITY JOURNAL; RANDOMIZED CONTROLLED TRIAL; SEROTONIN BLOOD LEVEL; SEROTONINERGIC SYSTEM; VOLUNTEER;

ADRENERGIC UPTAKE INHIBITORS; ADRENOCORTICOTROPIC HORMONE; ADULT; BRAIN; CYCLOPROPANES; DOUBLE-BLIND METHOD; DRUG ADMINISTRATION SCHEDULE; HUMANS; MALE; MIDDLE AGED; NOREPINEPHRINE; PAROXETINE; REFERENCE VALUES; SEROTONIN; SEROTONIN UPTAKE INHIBITORS; TIME FACTORS;

EID: 33746886308     PISSN: 00333158     EISSN: None     Source Type: Journal    
DOI: 10.1007/s00213-006-0456-6     Document Type: Letter

References (6)

1. Assie MB, Charveron M, Palmier C, Puozzo C, Moret C, Briley M (1992) Effects of prolonged administration of milnacipran, a new antidepressant, on receptors and monoamine uptake in the brain of the rat. Neuropharmacology 31:149-155
2. Iwakawa M, Terao T, Soya A, Kojima H, Inoue Y, Ueda N, Yoshimura R, Nakamura J (2004) A novel antipsychotic, perospirone, has antiserotonergic and antidopaminergic effects in human brain: findings from neuroendocrine challenge tests. Psychopharmacology 176:407-411
3. Kojima H, Terao T, Iwakawa M, Soya A, Inoue N, Shiraishi Y, Son Y, Soeda S, Ueda N, Yoshimura R, Nakamura J (2003) Paroxetine as a 5-HT neuroendocrine probe. Psychopharmacology 167:97-102
4. Moret C, Briley M (1997) Effects of milnacipran and pindolol on extracellular noradrenaline and serotonin levels in guinea pig hypothalamus. J Neurochem 69:815-822
5. Palmier C, Puozzo C, Lenehan T, Briley M (1989) Monoamine uptake inhibition by plasma from healthy volunteers after single oral doses of the antidepressant milnacipran. Eur J Clin Pharmacol 37:235-238
6. Reist C, Helmeste D, Albers L, Chhay H, Tang SW (1996) Serotonin indices and impulsivity in normal volunteers. Psychiatry Res 60:177-184