Optimization of kinetic parameters of enzymes

Biochemistry and Molecular Biology Education

Volumn 30, Issue 3, 2002, Pages 184-188

  Heinrich, Reinhart ^a   Meléndez Hevia, Enrique ^b   Cabezas, Héctor ^b  

^a HUMBOLDT UNIVERSITY   (Germany)

^b UNIVERSIDAD DE LA LAGUNA   (Spain)

Author keywords

[No Author keywords available]

Indexed keywords

BIOCHEMISTRY; CALCULATION; COMPUTER PROGRAM; COURSE CONTENT; EDUCATION; EDUCATION PROGRAM; ENZYME ACTIVITY; ENZYME ANALYSIS; ENZYME KINETICS; ENZYME MECHANISM; ENZYME SPECIFICITY; HUMAN; KINETICS; REVIEW; TEACHING; TECHNIQUE;

EID: 33746886293     PISSN: 14708175     EISSN: None     Source Type: Journal    
DOI: 10.1002/bmb.2002.494030030065     Document Type: Review

References (18)

1. E. Meléndez-Hevia, A. Isidoro (1985) The game of the pentose phosphate cycle, J. Theor. Biol. 117, 251-263.
2. R. Heinrich, H.-G. Holzhütter, S. Schuster (1991) Mathematical analysis of enzymic reaction systems using optimization principles, Eur. J. Biochem. 201, 1-21.
3. R. Meléndez, E. Meléndez-Hevia, M. Cascante (1997) How did glycogen structure evolve to satisfy the requirement for rapid mobilization of glucose? A problem of physical constraints in structure building, J. Mol. Evol. 45, 446-455.
4. T. G. Waddell, P. Repovic, E. Meléndez-Hevia, R. Heinrich, F. Montero (1997) Optimization of glycolysis: a new look at the efficiency of energy coupling, Biochem. Educ. 25, 204-205.
5. R. Heinrich, E. Meléndez-Hevia, F. Montero, J. C. Nuño, A. Stephani, T. G. Waddell (1999) The structural design of glycolysis: an evolutionary approach, Biochem. Soc. Trans. 27, 294-298.
6. R. Heinrich, E. Hoffmann, H.-G. Holzhütter (1990) Calculation of kinetic parameters of a reversible enzymatic reaction in states of maximal activity, Biomed. Biochim. Acta 49, 891-902.
7. R. Heinrich, E. Hoffmann (1991) Kinetic parameters of enzymatic reactions in states of maximal activity; an evolutionary approach, J. Theor. Biol. 151, 249-283.
8. T. Wilhelm, E. Hoffmann-Klipp, R. Heinrich (1994) An evolutionary approach to enzyme kinetics: optimization of ordered mechanisms, Bull. Math. Biol. 56, 65-106.
9. E. Klipp, R. Heinrich (1994) Evolutionary optimization of enzyme kinetic parameters; effect of constraints, J. Theor. Biol. 171, 309-323.
10. A. Cornish-Bowden (1976) The effect of natural selection on enzymic catalysis, J. Mol. Biol. 101, 1-9.
11. G. Petterson (1992) Evolutionary optimization of the catalytic efficiency of enzymes, Eur. J. Biochem. 206, 289-295.
12. R. A. Alberty, in P. D. Boyer, H. Lardy, K. Myback, Eds. (1959) The Enzymes, Vol. 1, Academic Press, New York, pp. 143-155.
13. S. Wolfram (1992) Mathematica, Version 4.0, Wolfram Research, Inc., Champaign, IL.
14. Microsoft Excel 2000 (1985-1999) Microsoft Corporation, Redmond, WA.
15. Microsoft Quick BASIC (1990) Version 7.1, for IBM PC. Microsoft Corporation, Redmond, WA.
16. D. Voet, J. G. Voet (1995) Biochemistry, 2nd ed., John Wiley & Sons, Inc., New York, pp. 353-354.
17. D. L. Nelson, M. M. Cox, (2000) Lehninger Principles of Biochemistry, 3rd ed., Worth Publishers, New York, pp. 263-264.
18. R. Heinrich, S. Schuster (1996) The Regulation of Cellular Systems, Chapman & Hall, New York, pp. 298-309.