Does male sexual behavior require progesterone?

Brain Research Reviews

Volumn 51, Issue 1, 2006, Pages 136-143

  Andersen, Monica Levy ^a   Tufik, Sergio ^a  

^a FEDERAL UNIVERSITY OF SÃO PAULO   (Brazil)

Author keywords

Erection; Hormonal control; Male; Progesterone; Sexual behavior

Indexed keywords

ANDROGEN; ANTIGESTAGEN; APOMORPHINE; CYPROTERONE ACETATE; DIENOGEST; GESTAGEN; LEVONORGESTREL; MEDROXYPROGESTERONE ACETATE; PROGESTERONE; PROMEGESTONE;

CLINICAL TRIAL; COITUS; DRUG POTENTIATION; DRUG STRUCTURE; HUMAN; HYPOTHALAMUS HYPOPHYSIS GONAD SYSTEM; INCEST; NEUROENDOCRINE SYSTEM; NONHUMAN; PEDOPHILIA; PRIORITY JOURNAL; RAPE; REGULATORY MECHANISM; REPTILE; REVIEW; RODENT; SEXUAL BEHAVIOR; SEXUAL DEVIATION; SEXUAL FUNCTION; SEXUALITY; ANIMAL; BIOSYNTHESIS; HYPOTHALAMUS HYPOPHYSIS SYSTEM; LEYDIG CELL; MALE; PHYSIOLOGY;

ANIMALS; HUMANS; HYPOTHALAMO-HYPOPHYSEAL SYSTEM; LEYDIG CELLS; MALE; PROGESTERONE; SEXUAL BEHAVIOR; SEXUAL BEHAVIOR, ANIMAL;

EID: 33746881770     PISSN: 01650173     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.brainresrev.2005.10.005     Document Type: Review

References (57)

1. Andersen M.L., and Tufik S. Distinct effects of paradoxical sleep deprivation and cocaine administration on sexual behavior in male rats. Addict. Biol. 7 (2002) 251-253
2. Andersen M.L., and Tufik S. The effects of dopaminergic agonists on genital reflexes in paradoxical sleep deprived male rats. Physiol. Behav. 84 (2005) 205-210
3. Andersen M.L., and Tufik S. Effects of progesterone blockade over cocaine-induced genital reflexes of paradoxical sleep deprived male rats. Horm. Behav. 47 (2005) 477-484
4. Andersen M.L., Bignotto M., and Tufik S. Cocaine-induced genital reflexes during paradoxical sleep deprivation and recovery. Physiol. Behav. 78 (2003) 255-259
5. Andersen M.L., Bignotto M., and Tufik S. The effect of apomorphine on genital reflexes in male rats deprived of paradoxical sleep. Physiol. Behav. 80 (2003) 211-215
6. Andersen M.L., Bignotto M., and Tufik S. Influence of paradoxical sleep deprivation and cocaine on development of spontaneous penile reflexes in rats of different ages. Brain Res. 968 (2003) 130-138
7. Andersen M.L., Bignotto M., Machado R.B., and Tufik S. Effects of chronic stress on steroid hormones secretion in male rats. Braz. J. Med. Biol. Res. 37 (2004) 791-797
8. Andersen M.L., Bignotto M., and Tufik S. Hormone treatment facilitates penile erection in castrated rats after sleep deprivation and cocaine. J. Neuroendocrinol. 16 (2004) 154-159
9. Andersen M.L., Papale L.A., and Tufik S. Diurnal variation in the genital reflexes and hormonal levels induced by paradoxical sleep deprivation and cocaine in male rats. Brain Res. Bull. 64 (2004) 215-220
10. Aron D.C., Finding J.W., and Tyrrell J.B. Glucocorticoids and adrenal androgens. In: Greenspan F.S., and Gardner D.G. (Eds). Basic and Clinical Endocrinology (2004), Lange Medical Books 362-411
11. Bradford J.M.W. Treatment of sexual offenders with cyproterone acetate. In: Sitse J.M.A. (Ed). Handbook of Sexology. The Pharmacology and Endocrinology of Sexual Function vol. 6 (1988), Elsevier, New York 526-536
12. Clark J.H., and Peck E.J. Female Sex Steroid: Receptors and Functions. 1st ed. 14 (1979), Springer-Verlag, New York
13. Cooper A.J. Progestogens in the treatment of male sex offenders: a review. Can. J. Psychol. 31 (1986) 73-79
14. Cooper A.J., Ismail A.A.A., Harding T., and Love D.N. The effects of clomiphene in impotence. Br. J. Psychol. 120 (1972) 327-330
15. Couse J.F., and Korach K.S. Exploring the role of sex steroid through studies of receptor deficient mice. J. Mol. Med. 76 (1998) 497-511
16. Crews D., Godwin D., Hartman V., Grammer M., Prediger E.A., and Sheppherd R. Intrahypothalamic implantation of progesterone in castrated male whiptail lizards (Cnemidophorus inornatus) elicits courtship and copulatory behavior and affects androgen receptor- and progesterone-mRNA expression in the brain. J. Neurosci. 15 (1996) 7347-7352
17. Crews D., and Sakata J. Evolution of brain mechanisms, controlling sexual behavior. In: Matsumoto A. (Ed). Sexual Differentiation of the Brain (2000), CRC Press, Boca Raton, FL 113-130
18. Csapo A.I., and Resch B.A. Induction of preterm labor in the rat by antiprogesterone. Am. J. Obstet. Gynecol. 134 (1979) 823-827
19. De Paolo L.V., and Barraclough C.A. Interactions of estradiol and progesterone on pituitary gonadotropin secretion: possible sites and mechanisms of action. Biol. Reprod. 20 (1979) 1173-1185
20. Edwards P.D. Progesterone receptor structure/function and crosstalk with cellular signalling pathways. In: Henry H.L., and Norman A.N. (Eds). Encyclopedia of Hormones vol. 3 (2003), Academic Press 8-22
21. Erpino M.J. Temporary inhibition by progesterone of sexual behavior in intact male mice. Horm. Behav. 4 (1973) 335-339
22. Feder H.H., and Marrone B.L. Progesterone: its role in the central nervous system as a facilitator and inhibitor of sexual behavior and gonadotropin release. Ann. N.Y. Acad. Sci. 286 (1977) 331-354
23. Gagne P. Treatment of sex offenders with medroxyprogesterone acetate. Am. J. Psychol. 138 (1981) 644-646
24. Grassman M., and Crews D. Progesterone induction of pesudocopulatory behavior and stimulus-response complementarity in an all-female lizard species. Horm. Behav. 20 (1986) 327-335
25. Guerra-Araiza C., Reyna-Neyra A., Salazar A.M., Cerbon M.A., Morimoto S., and Camacho-Arroyo I. Progesterone receptor isoforms expression in the prepuberal and adult male rat brain. Brain Res. Bull. 54 (2001) 13-17
26. Heller C.G., Laidlaw W.M., Harvey H.T., and Nelson W.O. Effects of progestational compounds on the reproductive processes of the human male. Ann. N.Y. Acad. Sci. 71 (1958) 165-172
27. Kalra P.S., and Kalra S.P. Circadian periodicities of serum androgens, progesterone, gonadotropins and luteinizing hormone-releasing hormone in male rats: the effects of hypothalamic deafferentation, castration and adrelectomy. Endocrinology 101 (1977) 1821-1827
28. Kastner P., Krust A., Turcotte B., Stropp U., Tora L., Gronemeyer H., and Chambon P. Two distinct estrogen-regulated promoters generate transcripts encoding the two functionally different human progesterone receptor forms A and B. EMBO J. 9 (1990) 1603-1614
29. Lagrange A.H., and Kelly M.J. Neuroactive steroid. In: Henry H.L., and Norman A.N. (Eds). Encyclopedia of Hormones vol. 3 (2003), Academic Press 8-22
30. Lauber A.H., Romano G.J., and Pfaff D.W. Gene expression for estrogen and progesterone receptor mRNAs in rat brain and possible relations to sexually dimorphic functions. J. Steroid Biochem. Mol. Biol. 40 (1991) 53-62
31. Lehne G.K. Treatment of sex offenders with medroxyprogesterone acetate. In: Sitse J.M.A. (Ed). Handbook of Sexology. The Pharmacology and Endocrinology of Sexual Function vol. 6 (1988), Elsevier, New York 516-525
32. Lindzey J., and Crews D. Hormonal control of courtship and copulatory behavior in male Cnemidophorus inornatus, a direct sexual ancestor of a unisexual, pathenogenetic lizard. Gen. Comp. Endocrinol. 64 (1986) 411-418
33. Lindzey J., and Crews D. Effects of progestins on sexual behaviour in castrated lizards (Cnemidophorus inornatus). J. Endocrinol. 119 (1988) 265-273
34. Lindzey J., and Crews D. Effects of progesterone and dihydrotestosterone on stimulation of androgen-dependent sex behavior, accessory sex structures, and in nitro binding characteristics of cytosolic androgen receptors in male whiptail lizards (Cnemidophorus inornatus). Horm. Behav. 27 (1993) 269-281
35. Lydon J.P., DeMayo F.J., Funk C.R., Mani D., Hughes A.R., Montgomery Jr. C.A., Shyamala G., Conneely O.M., and O'Malley B.W. Mice lacking progesterone receptor exhibit pleiotropic reproductive abnormalities. Genes Dev. 9 (1995) 2266-2278
36. Mahesh, V.B., Brann, D.W., Hendry, L.B. (1996). Diverse modes of action of progesterone and its metabolites, J. Steroid Mol. Biol. 56 (1-6), 209-219.
37. Mani S.K., Allen J.M.C., Lydon J.P., Mulac-Jericevic B., Blaustein J.D., DeMayo F.J., Conneely O., and O'Malley B.W. Dopamine requires the unoccupied progesterone receptor to induce sexual behavior in mice. Mol. Endocrinol. 10 (1996) 1728-1737
38. Mani S.K., Blaustein J.D., and O'Malley B.W. Progesterone receptor function from a behavioral perspective. Horm. Behav. 31 (1997) 244-255
39. Meites J., Steger R.W., and Huang H.H. Relation of neuroendocrine system to the reproductive decline in aging rats and human subjects. Fed. Proc. 39 (1980) 3168-3172
40. Money J. Use of an androgen-depleting hormone in the treatment of male sex offenders. J. Sex Res. 6 (1970) 165-172
41. Moore M.C., Whittier J.M., Billy A.J., and Crews D. Male-like behavior in an all-female lizard: relationship to ovarian cycle. Anim. Behav. 33 (1985) 284-289
42. Naville D., Keeney D.S., Jenkin G., Murry B.A., Head J.R., and Mason J.I. Regulation of expression of male-specific rat liver microsomal 3 beta-hydroxysteroid dehydrogenase. Mol. Endocrinol. 5 (1991) 1090-1100
43. Oettel M., and Mukhopadhyay A.K. Progesterone: the forgotten hormone in men?. Aging Male 7 (2004) 236-257
44. Pelletier A., Labrie F., Luu-The V., Tremblay Y., Belanger A., and Labrie F. Immunoelectron microscopic localization of three key steroidogenic enzymes (cytochrome P450(scc), 3 beta-hydroxysteroid dehydrogenase and cytochrome P450(c17)) in rat adrenal cortex and gonads. J. Endocrinol. 171 (2001) 373-383
45. Phelps S.M., Lydon J.P., O'Malley B.W., and Crews D. Regulation of male sexual behavior by progesterone receptor, sexual experience, and androgen. Horm. Behav. 34 (1998) 294-302
46. Romano G., Krust A., and Pfaff D. Expression and estrogen regulation of progesterone receptor mRNA in neurons of the mediobasal hypothalamus: an in situ hybridisation study. Mol. Endocrinol. 3 (1989) 1295-1300
47. Roselli C.E., and Chambers K. Sex differences in male-typical copulatory behaviors in response to androgen and estrogen treatment in rats. Reprod. Neuroendocrinol. 69 (1999) 290-298
48. Ross J., Claybaugh C., Clemens L.G., and Gorski R.A. Short latency induction of estrous behavior with intracerebral gonadal hormones in ovariectomyzed rats. Endocrinology 89 (1971) 32-38
49. Schiavi R.C., and White D. Androgens and male sexual function: a review of human studies. J. Sex Marital Ther. 2 (1976) 214-228
50. Tufik S., Lindsey C.J., and Carlini E.A. Does REM sleep deprivation induce a supersensitivity of dopaminergic receptors in rat brain?. Pharmacology 16 (1978) 98-105
51. Vimont-Vicary P., Jouvet-Mounier D., and Delorme F. Effects EEG et comportementaux des sommeil paradoxal chez le chat. Electroencephalogr. Clin. Neurophysiol. 20 (1966) 439-449
52. Wiedermann K., Seier F., Hirschmann M., Lauer C., and Holsboer F. Sleep endocrine effects of megestrol acetate and mifepristone, a mixed glucocorticoid- and progesterone-receptor antagonist. Neuropsychopharmacology 10S (1994) 21S (Part 2)
53. Witt D.M., Young L.J., and Crews D. Progesterone and sexual behavior in males. Psychoneuroendocrinology 19 (1994) 553-562
54. Witt D.M., Young L.J., and Crews D. Progesterone modulation of androgen-dependent sexual behavior in male rats. Physiol. Behav. 57 (1995) 307-313
55. Witt D.M., Reigada L.C., and Wengroff B.E. Intrahypothalamic progesterone regulates androgen-dependent sexual behavior in male rats. Abstr. -Soc. Neurosci. 23 (1997) 1357
56. Young L.J., Greenberg N., and Crews D. The effects of progesterone on sexual behavior in male green anole lizards (Anoliscarolinensis). Horm. Behav. 25 (1991) 477-488
57. Zumpe D., Clancy A.N., and Michael R.P. Progesterone decreases mating and estradiol uptake on preoptic areas of male monkeys. Physiol. Behav. 74 (2001) 603-612