Differential induction of electrophile-responsive element-regulated genes by n - 3 and n - 6 polyunsaturated fatty acids

FEBS Letters

Volumn 580, Issue 19, 2006, Pages 4587-4590

  van Beelen, Vincent A ^a   Aarts, Jac M M J G ^a   Reus, Astrid ^a   Mooibroek, Hans ^a   Sijtsma, Lolke ^a   Bosch, Dirk ^a   Rietjens, Ivonne M C M ^a   Alink, Gerrit M ^a  

^a WAGENINGEN UNIVERSITY   (Netherlands)

Author keywords

Chemoprevention; Electrophile responsive element; Gene induction; Lipid peroxidation; Phase II detoxification; Polyunsaturated fatty acids

Indexed keywords

ALPHA TOCOPHEROL; ANTIOXIDANT; ARACHIDONIC ACID; DOCOSAHEXAENOIC ACID; ICOSAPENTAENOIC ACID; OMEGA 3 FATTY ACID; OMEGA 6 FATTY ACID;

ANIMAL CELL; ARTICLE; CHEMOPROPHYLAXIS; CONTROLLED STUDY; DOSE RESPONSE; ENZYME ACTIVITY; ENZYME ASSAY; GENE CONTROL; GENE EXPRESSION; GENE INDUCTION; LIPID PEROXIDATION; MOUSE; NONHUMAN; PRIORITY JOURNAL; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION;

ANIMALS; CELL LINE; FATTY ACIDS, OMEGA-3; FATTY ACIDS, OMEGA-6; GENE EXPRESSION REGULATION; GLUTATHIONE TRANSFERASE; MICE; NADPH DEHYDROGENASE; REVERSE TRANSCRIPTASE POLYMERASE CHAIN REACTION;

EID: 33746877562     PISSN: 00145793     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.febslet.2006.07.028     Document Type: Article

References (29)

1. Kromhout D. The importance of n - 6 and n - 3 fatty acids in carcinogenesis. Med. Oncol. Tumor Pharmacother. 7 (1990) 173-176
2. Anti M., et al. Effects of different doses of fish oil on rectal cell proliferation in patients with sporadic colonic adenomas. Gastroenterology 107 (1994) 1709-1718
3. Deschner E.E., Lytle J.S., Wong G., Ruperto J.F., and Newmark H.L. The effect of dietary omega-3 fatty acids (fish oil) on azoxymethanol-induced focal areas of dysplasia and colon tumor incidence. Cancer 66 (1990) 2350-2356
4. Woutersen R.A., Appel M.J., van Garderen-Hoetmer A., and Wijnands M.V. Dietary fat and carcinogenesis. Mutat. Res. 443 (1999) 111-127
5. Davidson L.A., et al. Chemopreventive n - 3 polyunsaturated fatty acids reprogram genetic signatures during colon cancer initiation and progression in the rat. Cancer Res. 64 (2004) 6797-6804
6. Diggle C.P. In vitro studies on the relationship between polyunsaturated fatty acids and cancer: tumour or tissue specific effects?. Prog. Lipid Res. 41 (2002) 240-253
7. Siezen C.L., van Leeuwen A.I., Kram N.R., Luken M.E., van Kranen H.J., and Kampman E. Colorectal adenoma risk is modified by the interplay between polymorphisms in arachidonic acid pathway genes and fish consumption. Carcinogenesis 26 (2005) 449-457
8. Fan Y.Y., Spencer T.E., Wang N., Moyer M.P., and Chapkin R.S. Chemopreventive n - 3 fatty acids activate RXRalpha in colonocytes. Carcinogenesis 24 (2003) 1541-1548
9. Bartsch H., Nair J., and Owen R.W. Dietary polyunsaturated fatty acids and cancers of the breast and colorectum: emerging evidence for their role as risk modifiers. Carcinogenesis 20 (1999) 2209-2218
10. Whelan J., and McEntee M.F. Dietary (n - 6) PUFA and intestinal tumorigenesis. J. Nutr. 134 (2004) 3421S-3426S
11. Levonen A.L., Landar A., Ramachandran A., Ceaser E.K., Dickinson D.A., Zanoni G., Morrow J.D., and Darley-Usmar V.M. Cellular mechanisms of redox cell signalling: role of cysteine modification in controlling antioxidant defences in response to electrophilic lipid oxidation products. Biochem. J. 378 (2004) 373-382
12. Lee J.M., and Johnson J.A. An important role of Nrf2-ARE pathway in the cellular defense mechanism. J. Biochem. Mol. Biol. 37 (2004) 139-143
13. Wakabayashi N., et al. Keap1-null mutation leads to postnatal lethality due to constitutive Nrf2 activation. Nat. Genet. 35 (2003) 238-245
14. Holtzclaw W.D., Dinkova-Kostova A.T., and Talalay P. Protection against electrophile and oxidative stress by induction of phase 2 genes: the quest for the elusive sensor that responds to inducers. Adv. Enzyme Regul. 44 (2004) 335-367
15. Dinkova-Kostova A.T., Holtzclaw W.D., and Wakabayashi N. Keap1, the sensor for electrophiles and oxidants that regulates the phase 2 response, is a zinc metalloprotein. Biochemistry 44 (2005) 6889-6899
16. Dinkova-Kostova A.T., Holtzclaw W.D., and Kensler T.W. The role of Keap1 in cellular protective responses. Chem. Res. Toxicol. 18 (2005) 1779-1791
17. Pratico D. F(2)-isoprostanes: sensitive and specific non-invasive indices of lipid peroxidation in vivo. Atherosclerosis 147 (1999) 1-10
18. Chen C., and Kong A.N. Dietary chemopreventive compounds and ARE/EpRE signaling. Free Radic Biol. Med. 36 (2004) 1505-1516
19. Wasserman W.W., and Fahl W.E. Functional antioxidant responsive elements. Proc. Natl. Acad. Sci. USA 94 (1997) 5361-5366
20. Shureiqi I., Reddy P., and Brenner D.E. Chemoprevention: general perspective. Crit. Rev. Oncol. Hematol. 33 (2000) 157-167
21. Boerboom A.-M.J.F., et al. Newly constructed stable reporter cell lines for mechanistic studies on electrophile-responsive element-mediated gene expression reveal a role for flavonoid planarity. Biochem. Pharmacol. 72 (2006) 217-226
22. Ernster L. DT-diaphorase. Methods Enzymol. 10 (1967) 309-317
23. Benson A.M., Hunkeler M.J., and Talalay P. Increase of NAD(P)H:quinone reductase by dietary antioxidants: possible role in protection against carcinogenesis and toxicity. Proc. Natl. Acad. Sci. USA 77 (1980) 5216-5220
24. Habig W.H., Pabst M.J., and Jakoby W.B. Glutathione S-transferases. The first enzymatic step in mercapturic acid formation. J. Biol. Chem. 249 (1974) 7130-7139
25. 13C]alpha-linolenic acid to longer-chain fatty acids and partitioning towards beta-oxidation in older men. Br. J. Nutr. 90 (2003) 311-321
26. Li Y., and Jaiswal A.K. Regulation of human NAD(P)H:quinone oxidoreductase gene. Role of AP1 binding site contained within human antioxidant response element. J. Biol. Chem. 267 (1992) 15097-15104
27. Nguyen T., Sherratt P.J., and Pickett C.B. Regulatory mechanisms controlling gene expression mediated by the antioxidant response element. Annu. Rev. Pharmacol. Toxicol. 43 (2003) 233-260
28. Ren Y., and Smith A. Mechanism of metallothionein gene regulation by heme-hemopexin. Roles of protein kinase C, reactive oxygen species, and cis-acting elements. J. Biol. Chem. 270 (1995) 23988-23995
29. Arab K., Rossary A., Flourie F., Tourneur Y., and Steghens J.P. Docosahexaenoic acid enhances the antioxidant response of human fibroblasts by upregulating gamma-glutamyl-cysteinyl ligase and glutathione reductase. Br. J. Nutr. 95 (2006) 18-26