Calpastatin overexpression prevents progression of S-1,2-dichlorovinyl-l-cysteine (DCVC)-initiated acute renal injury and renal failure (ARF) in diabetes

Toxicology and Applied Pharmacology

Volumn 215, Issue 2, 2006, Pages 146-157

  Dnyanmote, Ankur V ^a   Sawant, Sharmilee P ^a   Lock, Edward A ^b   Latendresse, John R ^c   Warbritton, Alan A ^c   Mehendale, Harihara M ^a  

^a UNIVERSITY OF LOUISIANA AT MONROE   (United States)

^b Liverpool JM University   (United Kingdom)

^c NATIONAL CENTER FOR TOXICOLOGICAL RESEARCH   (United States)

Author keywords

Acute renal failure; Calpain; Calpastatin; Diabetes; Progression of injury; Tissue repair

Indexed keywords

1,2 DICHLOROVINYLCYSTEINE; ANTIMITOTIC AGENT; BROXURIDINE; CALPAIN; CALPASTATIN; COLCHICINE; TOXIC SUBSTANCE; UNCLASSIFIED DRUG;

ACUTE KIDNEY FAILURE; ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; CELL CYCLE S PHASE; CELL PROTECTION; COMPARATIVE STUDY; CONTROLLED STUDY; EXTRACELLULAR SPACE; HYPOTHESIS; IMMUNOHISTOCHEMISTRY; KIDNEY INJURY; KIDNEY PARENCHYMA; KIDNEY PROXIMAL TUBULE; KIDNEY TUBULE CELL; LETHAL DOSE; MALE; MOUSE; NEPHROTOXICITY; NONHUMAN; PROTEIN EXPRESSION; STREPTOZOCIN DIABETES; URINE;

ACETYLCYSTEINE; ANIMALS; ANTIMITOTIC AGENTS; CALCIUM-BINDING PROTEINS; CALPAIN; COLCHICINE; CYSTEINE PROTEINASE INHIBITORS; DIABETES MELLITUS, EXPERIMENTAL; DRUG THERAPY, COMBINATION; KIDNEY FAILURE, ACUTE; KIDNEY FUNCTION TESTS; KIDNEY TUBULES, PROXIMAL; LONGEVITY; MALE; MICE; REGENERATION;

EID: 33746865255     PISSN: 0041008X     EISSN: 10960333     Source Type: Journal    
DOI: 10.1016/j.taap.2006.01.018     Document Type: Article

References (40)

1. (2+)-dependent thiol protease) with its endogenous inhibitor calpastatin in myoblasts. J. Cell. Biochem. 74 (1999) 522-531
2. Barnoy S., Supino-Rosin L., and Kosower N.S. Regulation of calpain and calpastatin in differentiating myoblasts: mRNA levels, protein synthesis and stability. Biochem. J. 15 (2000) 413-420
3. Bonventre J.V. Molecular response to cytotoxic injury: role of inflammation, MAP kinases, and endoplasmic reticulum stress response. Semin. Nephrol. 23 (2003) 439-448
4. Bronk S.F., and Gores G.J. pH-dependent nonlysosomal proteolysis contributes to lethal anoxic injury of rat hepatocytes. Am. J. Physiol. 264 (1993) G744-G751
5. Croall D.E., and DeMartino G.N. Calcium-activated neutral protease (calpain) system: structure, function, and regulation. Physiol. Rev. 71 (1991) 813-847
6. De Jongh K.S., Colvin A.A., Wang K.K., and Catterall W.A. Differential proteolysis of the full-length form of the L-type calcium channel alpha 1 subunit by calpain. J. Neurochem. 63 (1994) 1558-1564
7. Diaz F., and Bourguignon L.Y. Selective down-regulation of IP(3)receptor subtypes by caspases and calpain during TNF alpha -induced apoptosis of human T-lymphoma cells. Cell Calcium 27 (2000) 315-328
8. Dnyanmote A.V., Sawant S.P., Lock E.A., Latendresse J.R., Warbritton A.A., and Mehendale H.M. Diabetic mice are protected from normally lethal nephrotoxicity of S-1,2-dichlorovinyl-l-cysteine (DCVC): role of nephrogenic tissue repair. Toxicol. Appl. Pharmacol. 211 (2006) 133-147
9. Dolan V., Hensey C., and Brady H.R. Diabetic nephropathy: renal development gone awry?. Pediatr. Nephrol. 18 (2003) 75-84
10. Edelstein C.L. Calcium-mediated proximal tubular injury-What is the role of cysteine proteases?. Nephrol., Dial., Transplant. 15 (2000) 141-144
11. Edelstein C.L., Wieder E.D., Yaqoob M.M., Gengaro P.E., Burke T.J., Nemenoff R.A., and Schrier R.W. The role of cysteine proteases in hypoxia-induced rat renal proximal tubular injury. Proc. Natl. Acad. Sci. 92 (1995) 7662-7666
12. Edelstein C.L., Yaqoob M.M., Alkhunaizi A.M., Gengaro P.E., Nemenoff R.A., Wang K.K., and Schrier R.W. Modulation of hypoxia-induced calpain activity in rat renal proximal tubules. Kidney Int. 50 (1996) 1150-1157
13. Edelstein C.L., Ling H., Gengaro P.E., Nemenoff R.A., Bahr B.A., and Schrier R.W. Effect of glycine on prelethal and postlethal increases in calpain activity in rat renal proximal tubules. Kidney Int. 52 (1997) 1271-1280
14. Johnson W. Growth factors in progressive renal disease. Nephrology 5 (2000) 251-261
15. Kohli V., Gao W., Camargo Jr. C.A., and Clavien P.A. Calpain is a mediator of preservation-reperfusion injury in rat liver transplantation. Proc. Natl. Acad. Sci. 94 (1997) 9354-9359
16. Kohli V., Madden J.F., Bentley R.C., and Clavien P.A. Calpain mediates ischemic injury of the liver through modulation of apoptosis and necrosis. Gastroenterology 116 (1999) 168-178
17. Korrapati M.C., Lock E.A., and Mehendale H.M. Molecular mechanisms of enhanced renal cell division in protection against S-1,2-dichlorovinyl-l-cysteine -induced acute renal failure and death. Am. J. Physiol.: Renal. Physiol. 299 (2005) F175-F185
18. Limaye P.B., Apte U.M., Shankar K., Bucci T.J., Warbritton A., and Mehendale H.M. Calpain released from dying hepatocytes mediates progression of acute liver injury induced by model hepatotoxicants. Toxicol. Appl. Pharmacol. 191 (2003) 211-226
19. Limaye P.B., Apte U.M., Palkar P.S., Latendresse J.C., and Mehendale H.M. Expression of calpastatin and annexin I in newly divided hepatocytes: mechanism behind resistance from acute liver failure. Hepatology 38 (2003) 451A
20. Limaye, P.B., Bhave, V.S., Palkar, P.S., Apte, U.M., Sawant, S.P., Latendresse, J.R., Yu, S., Reddy, J.K., Mehendale, H.M., 2006. Upregulation of calpastatin in regenerating and developing livers: Role in resistance against hepatotoxicity. Hepatology 44, in press.
21. Maki M., Bagci H., Hamaguchi K., Ueda M., Murachi T., and Hatanaka M. Inhibition of calpain by a synthetic oligopeptide corresponding to an exon of the human calpastatin gene. J. Biol. Chem. 264 (1989) 18866-18869
22. (2+)-channel. FEBS Lett. 323 (1993) 229-232
23. Mehendale H.M., and Limaye P.B. Calpain: a death protein that mediates progression of liver injury. Trends Pharmacol. Sci. 26 (2005) 232-236
24. Nony P.A., and Schnellmann R.G. Mechanisms of renal cell repair and regeneration after acute renal failure. J. Pharmacol. Exp. Ther. 304 (2003) 905-912
25. Rao V.C., and Mehendale H.M. Effect of colchicine on hepatobiliary function in CCl4 treated rats. Biochem. Pharmacol. 42 (1991) 2323-2332
26. Rao V.C., and Mehendale H.M. Colchicine antimitosis abolishes CCl4 autoprotection. Toxicol. Pathol. 19 (1991) 597-606
27. Roberts E., Ahluwalia M.B., Lee G., Chan C., Sarma D.S., and Farber E. Resistance to hepatotoxins acquired by hepatocytes during liver regeneration. Cancer Res. 43 (1983) 28-34
28. Ruch R.J., Klaunig J.E., and Pereira M.A. Selective resistance to cytotoxic agents in hepatocytes isolated from partially hepatectomized and neoplastic mouse liver. Cancer Lett. 26 (1985) 295-301
29. Sawant S.P., Dnyanmote A.V., Mitra M.S., Chilakapati J., Warbritton A., Latendresse J.R., and Mehendale H.M. Protective effect of type 2 diabetes on acetaminophen-induced hepatotoxicity in male Swiss Webster mice. J. Pharmacol. Exp. Ther. 316 (2006) 507-519
30. Shankar K., Vaidya V.S., Apte U.M., Manautou J.E., Ronis M.J., Bucci T.J., and Mehendale H.M. Type 1 diabetic mice are protected from acetaminophen hepatotoxicity. Toxicol. Sci. 73 (2003) 220-234
31. Takano E., Kitahara A., Kannagi R., and Murachi T. Enzyme immunoassay of calpain I and calpastatin and its application to the analysis of human erythrocyte hemolysate. J. Appl. Biochem. 6 (1984) 117-125
32. Takano T., Soltoff S.P., Murdaugh S., and Mandel L.J. Intracellular respiratory dysfunction and cell injury in short-term anoxia of rabbit renal proximal tubules. J. Clin. Invest. 76 (1985) 2377-2384
33. Thadhani R., Pascual M., and Bonventre J.V. Medical progress: acute renal failure. N. Eng. J. Med. 334 (1996) 1448-1460
34. 35S-1, 2-dichlorovinyl-l-cysteine nephrotoxicity in vivo and in cultured proximal tubule epithelial cells. Lab. Invest. 66 (1992) 474-484
35. 2+-dependent neutral protease. Arch. Biochem. Biophys. 260 (1988) 696-704
36. Waters S.L., and Schnellmann R.G. Examination of the mechanisms of action of diverse cytoprotectants in renal cell death. Toxicol. Pathol. 26 (1998) 58-63
37. Waters S.L., Sarang S.S., Wang K.K., and Schnellmann R.G. Calpains mediate calcium and chloride influx during the late phase of cell injury. J. Pharmacol. Exp. Ther. 283 (1997) 1177-1184
38. Wetzels J.F., Yu L., Wang X., Kribben A., Burke T.J., and Schrier R.W. Calcium modulation and cell injury in isolated rat proximal tubules. J. Pharmacol. Exp. Ther. 267 (1993) 176-180
39. Wilson P.D., and Hartz P.A. Mechanisms of cyclosporine A toxicity in defined cultures of renal tubule epithelia: a role for cysteine proteases. Cell Biol. Int. Rep. 15 (1991) 1243-1258
40. Yoshida K. Myocardial ischemia-reperfusion injury and proteolysis of fodrin, ankyrin, and calpastatin. Methods Mol. Biol. 144 (2000) 267-275