The presence of m1 to m5 receptors in human sclera: Evidence of the sclera as a potential site of action for muscarinic receptor antagonists

Current Eye Research

Volumn 31, Issue 7-8, 2006, Pages 587-597

  Qu, Jia ^a   Zhou, Xiangtian ^a   Xie, Ruozhong ^a   Zhang, Lihua ^a   Hu, Danning ^a,b   Li, He ^a   Lu, Fan ^a  

^a WENZHOU MEDICAL UNIVERSITY   (China)

^b NEW YORK MEDICAL COLLEGE   (United States)

Author keywords

Human; Muscarinic receptor; Myopia; Scleral fibroblast

Indexed keywords

MESSENGER RNA; MUSCARINIC M1 RECEPTOR; MUSCARINIC M2 RECEPTOR; MUSCARINIC M3 RECEPTOR; MUSCARINIC M4 RECEPTOR; MUSCARINIC M5 RECEPTOR; MUSCARINIC RECEPTOR BLOCKING AGENT;

ARTICLE; CELL LINE; CONTROLLED STUDY; DRUG BINDING SITE; DRUG RECEPTOR BINDING; FIBROBLAST CULTURE; HUMAN; HUMAN TISSUE; IMMUNOCYTOCHEMISTRY; IMMUNOHISTOCHEMISTRY; MOLECULAR WEIGHT; NORTHERN BLOTTING; NUCLEOTIDE SEQUENCE; PRIORITY JOURNAL; PROTEIN ANALYSIS; PROTEIN EXPRESSION; RECEPTOR INTRINSIC ACTIVITY; RECEPTOR SENSITIVITY; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; SCLERA; TISSUE SECTION; WESTERN BLOTTING;

ADULT; BLOTTING, NORTHERN; BLOTTING, WESTERN; CELL LINE; FIBROBLASTS; GENE EXPRESSION REGULATION; HUMANS; IMMUNOHISTOCHEMISTRY; MUSCARINIC ANTAGONISTS; MYOPIA; PROTEIN ISOFORMS; RECEPTORS, MUSCARINIC; REVERSE TRANSCRIPTASE POLYMERASE CHAIN REACTION; RNA, MESSENGER; SCLERA;

EID: 33746849332     PISSN: 02713683     EISSN: 14602202     Source Type: Journal    
DOI: 10.1080/02713680600770609     Document Type: Article

References (49)

1. McBrien NA, Gentle A. Role of the sclera in the development and pathological complications of myopia. Prog Retin Eye Res. 2003;22:307-338.
2. Christensen AM, Wallman J. Evidence that increased scleral growth underlies visual deprivation myopia in chicks. Invest Ophthalmol Vis Sci. 1991;32:2143-2150.
3. Gottlieb MD, Joshi HB, Nickla DL. Scleral changes in chicks with form-deprivation myopia. Curr Eye Res. 1990;9:1157-1165.
4. Phillips JR, Khalaj M, McBrien NA. Induced myopia associated with increased scleral creep in chick and tree shrew eyes. Invest Ophthalmol Vis Sci. 2000;41:2028-2034.
5. Gentle A, McBrien NA. Modulation of scleral DNA synthesis in development of and recovery from induced axial myopia in the tree shrew. Exp Eye Res. 1999;68:155-163.
6. Luft WA, Ming Y, Stell WK. Variable effects of previously untested muscarinic receptor antagonists on experimental myopia. Invest Ophthalmol Vis Sci. 2003;44:1330-1338.
7. Yen MY, Liu JH, Kao SC, Shiao CH. Comparison of the effect of atropine and cyclopentolate on myopia. Ann Ophthalmol. 1989;21:180-182.
8. Vogel R. Pharmaceutical agents and the prevention or reduction of progressive myopia. Acta Ophthalmol Suppl. 1988;185:134-138.
9. Duncan G, Collison DJ. Role of the non-neuronal cholinergic system in the eye. Life Sci. 2003;72:2013-2019.
10. Lind GJ, Chew SJ, Marzani D, Wallman J. Muscarinic acetylcholine receptor antagonists inhibit chick scleral chondrocytes. Invest Ophthalmol Vis Sci. 1998;39:2217-2231.
11. Rada JA, Johnson JM, Achen VR, Rada KG. Inhibition of scleral proteoglycan synthesis blocks deprivation-induced axial elongation in chicks. Exp Eye Res. 2002;74:205-215.
12. Buchli R, Ndoye A, Rodriguez JG, et al. Identification and characterization of muscarinic acetylcholine receptor subtypes expressed in human skin melanocytes. Mol Cellular Biochem. 2001;228:57-72.
13. Collison DJ, Coleman RA, James RS, et al. Characterization of muscarinic receptors in human lens cells by pharmacologic and molecular techniques. Invest Ophthalmol Vis Sci. 2000;41:2633-2641.
14. Gil DW, Krauss HA, Bogardus AM, WoldeMussie E. Muscarinic receptor subtypes in human iris-ciliary body measured by immunoprecipitation. Invest Ophthalmol Vis Sci. 1997;38:1434-1442.
15. Truong HT, Cottriall CL, McBrien NA. Expression of muscarinic receptors in tree shrew ocular tissues. Invest Ophthalmol Vis Sci. 2000;41:S132.
16. Tigges M, Tigges J, Rees H, et al. Distribution of muscarinic cholinergic receptor proteins m1 to m4 in area 17 of normal and monocularly deprived rhesus monkeys. J Comp Neurol. 1997;388:130-145.
17. Schliebs R, Bigl V, Biesold D. Development of muscarinic cholinergic receptor binding in the visual system of monocularly deprived and dark reared rats. Neurochem Res. 1982;7:1181-1198.
18. Vessey KA, Cottriall CL, McBrien NA. Muscarinic receptor protein expression in the ocular tissues of the chick during normal and myopic eye development. Brain Res Dev Brain Res. 2002;135:79-86.
19. Tigges M, Iuvone PM, Fernandes A, et al. Effects of muscarinic cholinergic receptor antagonists on postnatal eye growth of rhesus monkeys. Optom Vis Sci. 1999;76:397-407.
20. Fischer AJ, Miethke P, Morgan IG, Stell WK. Cholinergic amacrine cells are not required for the progression and atropine-mediated suppression of form-deprivation myopia. Brain Res. 1998;794:48-60.
21. Yin GC, Gentle A, McBrien NA. Muscarinic antagonist control of myopia: A molecular search for the M1 receptor in chick. Mol Vis. 2004;10:787-793.
22. Schwahn HN, Kaymak H, Schaeffel F. Effects of atropine on refractive development, dopamine release, and slow retinal potentials in the chick. Vis Neurosci. 2000;17:165-176
23. Gordonson LC. Interventions to retard myopia progression. Ophthalmology. 2003;110:1287.
24. Pollard ZF. A report of two more supporters of the medical management of myopia with topical atropine eyedrops and photochromic bifocals. Binocul Vis Strabismus Q. 2002;17:177.
25. Kennedy RH, Dyer JA, Kennedy MA, et al. Reducing the progression of myopia with atropine: A long term cohort study of Olmsted County students. Binocul Vis Strabismus Q. 2000;15:281-304.
26. Hu DN, McCormick SA, Ritch R, Pelton-Henrion K. Studies of human uveal melanocytes in vitro: Isolation, purification and cultivation of human uveal melanocytes. Invest Ophthalmol Vis Sci. 1993;33:2210-2219.
27. Hu DN. Effect of TGF-β and cAMP-elevating agents on the growth of human scleral fibroblasts in vitro. In: Lin LK, Shih YF, Hung PT. Myopia Updates. Springer: Tokyo; 2000:131-132.
28. mAChR M1(H-120):sc-9106. Santa Cruz Biotechnology, Inc (Santa Cruz city, CA, USA); 2001.
29. mAChR M2(H-170):sc-9107. Santa Cruz Biotechnology, Inc (Santa Cruz city, CA, USA); 2001.
30. mAChR M3(H-210):sc-9108. Santa Cruz Biotechnology, Inc (Santa Cruz city, CA, USA); 2001.
31. mAChR M4(H-175):sc-9109. Santa Cruz Biotechnology, Inc (Santa Cruz city, CA, USA); 2001.
32. mAChR M5(H-197):sc-9110. Santa Cruz Biotechnology, Inc (Santa Cruz city, CA, USA); 2001.
33. Newkirk RF, Mack J. Improved indirect fluorescence immunocytochemical method using counterstains. Biotechniques. 1992;13:536-538.
34. Li YQ, Chen P, Haimovitz-Friedman A, et al. Endothelial apoptosis initiates acute blood-brain barrier disruption after ionizing radiation. Cancer Res. 2003;15;5950-5956.
35. Rada JA, Perry CA, Slover ML, Achen VR. Gelatinase A and TIMP-2 expression in the fibrous sclera of myopic and recovering chick eyes. Invest Ophthalmol Vis Sci. 1999;40:3091-3099.
36. Khanna S, Porter JD. Evidence for rectus extraocular muscle pulleys in rodents. Invest Ophthalmol Vis Sci. 2001;42:1986-1992.
37. Tuori A, Virtanen I, Aine E, Uusitalo H. The expression of tenascin and fibronectin in keratoconus, scarred and normal human cornea. Graefes Arch Clin Exp Ophthalmol. 1997;235:222-229.
38. Zeng F, Wess J. Molecular aspects of muscarinic receptor dimerization. Neuropsychopharmacology. 2000;23:S19-S31.
39. Buchli R, Ndoye A, Rodriguez JG, et al. Human skin fibroblasts express m2, m4, and m5 subtypes of muscarinic acetylcholine receptors. J Cell Biochem. 1999;74:264-277.
40. Grando SA, Zelickson BD, Kist DA, et al. Keratinocyte muscarinic acetylcholine receptors: Immunolocalization and partial characterization. J Invest Dermatol. 1995;104:95-100.
41. Ndoye A, Buchli R, Greenberg B, et al. Identification and mapping of keratinocyte muscarinic acetylcholine receptor subtypes in human epidermis. J Invest Dermatol. 1998;111:101-108.
42. Liles WC, Nathanson NM. Regulation of neuronal muscarinic acetylcholine receptor number by protein glycosylation. J Neurochem. 1986;46:89-95.
43. Alge CS, Suppmann S, Priglinger SG, et al. Comparative Proteome analysis of native differentiated and cultured dedifferentiated human RPE cells. Invest Ophthalmol Vis Sci. 2003;44:3629-3641.
44. Matsumoto S, Yorio T, DeSantis L, Pang IH. Muscarinic effects on cellular functions in cultured human ciliary muscle cells. Invest Ophthalmol Vis Sci. 1994;35:3732-3738.
45. Ishizaka N, Noda M, Yokoyama S, et al. Muscarinic acetylcholine receptor subtypes in the human iris. Brain Res. 1998;787: 344-347.
46. Zhang X, Erickson K. Regulation of m3-muscarinic-receptor and messenger: RNA expression in cultured ciliary muscle-cells. Invest Ophthalmol Vis Sci. 1995;36:S593.
47. Wiederholt M, Schafer R, Wagner U, Lepple-Wienhues A. Contractile response of the isolated trabecular meshwork and ciliary muscle to cholinergic and adrenergic agents. Ger J Ophthalmol. 1996;5:146-153.
48. Wallman J. Nature and nurture of myopia. Nature. 1994;371:201-202.
49. McBrien NA, Moghaddam HO, Reeder AP. Atropine reduces experimental myopia and eye enlargement via a nonaccommodative mechanism. Invest Ophthalmol Vis Sci. 1993;34:205-215.