An integrated analysis of alprostadil topical cream for the treatment of erectile dysfunction in 1732 patients

Urology

Volumn 68, Issue 2, 2006, Pages 386-391

  Padma Nathan, Harin ^a   Yeager, James L ^b  

^a UNIVERSITY OF SOUTHERN CALIFORNIA   (United States)

^b JL Yeager and Associates Inc   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ORGANIC NITRATE; PHOSPHODIESTERASE V INHIBITOR; PLACEBO; PROSTAGLANDIN E1; SILDENAFIL; TADALAFIL; VARDENAFIL;

ADULT; AGED; APPLICATION SITE BURNING; APPLICATION SITE HYPERESTHESIA; APPLICATION SITE PARESTHESIA; APPLICATION SITE PRURITUS; APPLICATION SITE RASH; APPLICATION SITE REACTION; ARTICLE; BALANITIS; BURNING SENSATION; CLINICAL TRIAL; CONTROLLED CLINICAL TRIAL; CONTROLLED STUDY; DATA ANALYSIS; DIABETES MELLITUS; DIZZINESS; DOUBLE BLIND PROCEDURE; DRUG EFFICACY; DRUG INDUCED HEADACHE; DRUG SAFETY; DRUG TOLERABILITY; EDEMA; EJACULATION; ERECTILE DYSFUNCTION; ERYTHEMA; GENITAL ERYTHEMA; GENITAL PAIN; HUMAN; HYPERESTHESIA; LABORATORY TEST; MAJOR CLINICAL STUDY; MALE; MULTICENTER STUDY; NEUROLOGIC DISEASE; PENIS DISEASE; PENIS ERECTION; PRIORITY JOURNAL; RANDOMIZED CONTROLLED TRIAL; RIGIDITY; SENSORY DYSFUNCTION; SKIN DISEASE; UROGENITAL SYSTEM; VAGINAL BURNING SENSATION; VAGINITIS;

ADMINISTRATION, TOPICAL; ALPROSTADIL; DOSAGE FORMS; DOUBLE-BLIND METHOD; HUMANS; IMPOTENCE; MALE; MIDDLE AGED;

EID: 33746838868     PISSN: 00904295     EISSN: 15279995     Source Type: Journal    
DOI: 10.1016/j.urology.2006.02.027     Document Type: Article

References (18)

1. Utiger R.D. A pill for impotence. N Engl J Med 338 (1998) 1458-1459
2. Goldstein I., Lue T.F., Padma-Nathan H., et al., Sildenafil Study Group. Oral sildenafil in the treatment of erectile dysfunction. N Engl J Med 338 (1998) 1397-1404
3. Brock G.B., McMahon C.G., Chen K.K., et al. Efficacy and safety of tadalafil for the treatment of erectile dysfunction. results of integrated analyses. J Urol 168 (2002) 1332-1336
4. Hellstrom W.J., Gittelman M., Karlin G., et al. Vardenafil for treatment of men with erectile dysfunction. efficacy and safety in a randomized, double-blind, placebo-controlled trial. J Androl 23 (2002) 763-771
5. Pryor J.L., and Redmon B. New therapies and delivery mechanisms for treatment of erectile dysfunction. Int J Impot Res 12 suppl 4 (2000) S158-S162
6. MMMHS: Major Multinational Male Health Survey findings support the need for new treatment options for the improvement of erectile function. Available at: http://www.bayer.co.jp/byl/english/news/pub/news2002-9-26_2.html. Accessed October 31, 2003.
7. Linet O.I., Ogrinc F.G., and Alprostadil Study Group. Efficacy and safety of intracavernosal alprostadil in men with erectile dysfunction. N Engl J Med 334 (1996) 873-877
8. Padma-Nathan H., Hellstrom W.J., Kaiser F.E., et al., Medicated Urethral System for Erection (MUSE) Study Group. Treatment of men with erectile dysfunction with transurethral alprostadil. N Engl J Med 336 (1997) 1-7
9. Williams G., Abbou C.C., Amar E.T., et al., MUSE Study Group. Efficacy and safety of transurethral alprostadil therapy in men with erectile dysfunction. Br J Urol 81 (1998) 889-894
10. Buyuktimkin N., Buyuktimkin S., and Rytting J.H. Alky-N,N-disubstituted amino acetates. In: Smith E., and Maibach H.I. (Eds). Percutaneous Penetration Enhancers (1995), CRC Press, Boca Raton 91-102
11. Buyuktimkin N., Buyuktimkin S., and Rytting J.H. Chemical means of transdermal drug permeation enhancement. In: Ghosh T.K., Pfister W.R., and Yum S.I. (Eds). Transdermal and Topical Drug Delivery Systems (1997), Interpharm Press, Englewood, Colo 357-475
12. Yeager J., and Beihn R. Retention and migration of alprostadil cream applied topically to the glans meatus for erectile dysfunction. Int J Impot Res 17 (2005) 91-95
13. Rosen R.C., Riley A., Wagner G., et al. The international index of erectile function (IIEF). a multidimensional scale for assessment of erectile dysfunction. Urology 49 (1997) 822-830
14. Padma-Nathan H., McMurray J.G., Pullman W.E., et al. for the IC351 On-Demand Dosing Study Group. On-demand IC351 (Cialis) enhances erectile function in patients with erectile dysfunction. Int J Impot Res 13 (2001) 2-9
15. Anderson P., Gommersall L., Dickon H., et al. New phosphodiesterase inhibitors in the treatment of erectile dysfunction. Expert Opin Pharmacother 5 (2004) 2241-2249
16. Young J. Vardenafil. Expert Opin Investig Drugs 11 (2002) 1487-1496
17. Steidle C., Padma-Nathan H., Salem S., et al. Topical alprostadil cream for the treatment of erectile dysfunction. a combined analysis of the phase II program. Urology 60 (2002) 1077-1082
18. Padma-Nathan H., Steidle C., Salem S., et al. The efficacy and safety of a topical alprostadil cream, Alprox-TD, for the treatment of erectile dysfunction. two phase 2 studies in mild-to-moderate and severe ED. Int J Impot Res 15 (2003) 10-17