Structure-based Stability Engineering of the Mouse IgG1 Fab Fragment by Modifying Constant Domains

Journal of Molecular Biology

Volumn 361, Issue 4, 2006, Pages 687-697

  Teerinen, Tuija ^a   Valjakka, Jarkko ^b   Rouvinen, Juha ^b   Takkinen, Kristiina ^a  

^a VTT TECHNICAL RESEARCH CENTRE OF FINLAND   (Finland)

^b UNIVERSITY OF EASTERN FINLAND   (Finland)

Author keywords

CH1 CL domain; Fab fragment; sequence alignment; stability engineering; structure comparison

Indexed keywords

GUANIDINE; IMMUNOGLOBULIN F(AB) FRAGMENT; IMMUNOGLOBULIN G1; ISOLEUCINE; VALINE;

ARTICLE; CIRCULAR DICHROISM; CONCENTRATION RESPONSE; DENATURATION; ENZYME LINKED IMMUNOSORBENT ASSAY; GENETIC ENGINEERING; HYDROPHILICITY; HYDROPHOBICITY; POINT MUTATION; PRIORITY JOURNAL; PROTEIN DOMAIN; PROTEIN EXPRESSION; PROTEIN FOLDING; PURIFICATION; SEQUENCE ALIGNMENT; SITE DIRECTED MUTAGENESIS; THERMODYNAMICS; THERMOSTABILITY; WILD TYPE;

EID: 33746829952     PISSN: 00222836     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.jmb.2006.06.073     Document Type: Article

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