Outcome predictors for severe obsessive-compulsive patients in intensive residential treatment

Journal of Psychiatric Research

Volumn 40, Issue 6, 2006, Pages 511-519

  Stewart, S Evelyn ^a,b   Yen, Chen Hsing ^a   Stack, Denise Egan ^b   Jenike, Michael A ^a,b  

^a MASSACHUSETTS GENERAL HOSPITAL   (United States)

^b MCLEAN HOSPITAL   (United States)

Author keywords

Gender; Obsessive compulsive disorder; Outcome; Predictor; Severity; Treatment

Indexed keywords

ADOLESCENT; ADULT; AGE; AGED; ARTICLE; BECK DEPRESSION INVENTORY; COMPARATIVE STUDY; CONTROLLED STUDY; DEPRESSION; DISEASE SEVERITY; EMPLOYMENT STATUS; FAMILY HISTORY; FEMALE; GENDER; HOSPITAL ADMISSION; HOSPITALIZATION; HUMAN; INTENSIVE RESIDENTIAL TREATMENT; MAJOR CLINICAL STUDY; MALE; MARRIAGE; MEDICAL RESEARCH; MULTIPLE REGRESSION; OBSESSIVE COMPULSIVE DISORDER; OUTCOME ASSESSMENT; PREDICTION; PRIORITY JOURNAL; REGRESSION ANALYSIS; RESIDENTIAL CARE; SOCIAL PSYCHOLOGY; STUDENT T TEST; TIC; TIME SERIES ANALYSIS; TREATMENT OUTCOME;

ADOLESCENT; ADULT; AGED; CHI-SQUARE DISTRIBUTION; CHILD; CHILD, PRESCHOOL; FEMALE; HUMANS; MALE; MIDDLE AGED; OBSESSIVE-COMPULSIVE DISORDER; PERSONALITY INVENTORY; PREDICTIVE VALUE OF TESTS; PSYCHIATRIC STATUS RATING SCALES; PSYCHOMETRICS; RESIDENTIAL TREATMENT; RETROSPECTIVE STUDIES; SEVERITY OF ILLNESS INDEX; SEX FACTORS; TREATMENT OUTCOME;

EID: 33746785568     PISSN: 00223956     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.jpsychires.2005.08.007     Document Type: Article

References (74)

1. Ackerman D.L., and Greenland S. Multivariate meta-analysis of controlled drug studies for obsessive-compulsive disorder. Journal of Clinical Psychopharmacology 22 3 (2002) 309-317
2. Ackerman D.L., Greenland S., and Bystritsky A. Side effects as predictors of drug response in obsessive-compulsive disorder. Journal of Clinical Psychopharmacology 19 (1999) 459-465
3. Ackerman D.L., Greenland D., and Bystritsky A. Clinical characteristics of response to fluoxetine treatment of obsessive-compulsive disorder. Journal of Clinical Psychopharmacology 18 3 (1998) 185-192
4. Ackerman D.L., Greenland S., Bystritski A., Morgenstern H., and Katz R.J. Predictors of treatment response in obsessive-compulsive disorder: multivariate analyses from a multicentre trial of clomipramine. Journal of Clinical Psychopharmacology 14 4 (1994) 247-254
5. Alarcon R., Libb J., and Spitler D. A predictive study of OCD response to clomipramine. Journal of Clinical Psychopharmacology 13 (1993) 210-213
6. Alonso P., Menchon J.M., Pifarre J., Mataix-Cols D., Torres L., Salgado P., and Vallejo J. Long-term follow-up and predictors of clinical outcome in obsessive-compulsive patients treated with serotonergic reuptake inhibitors and behavioral therapy. Journal of Clinical Psychiatry 62 7 (2001) 535-540
7. AuBuchon P.G., and Malatesta V.J. Obsessive-compulsive patients with comorbid personality disorder: associated problems and response to a comprehensive behavior therapy. Journal of Clinical Psychiatry 55 (1994) 448-453
8. Baer L., Jenike M.A., Black D.W., Treece C., Rosenfeld R., and Gresit J. Effect of axis II diagnoses on treatment outcome with clomipramine in 55 patients with obsessive-compulsive disorder. Archives of General Psychiatry 49 (1992) 862-866
9. Ball S.G., Baer L., and Otto M.W. Symptom subtypes of obsessive-compulsive disorder in behavioral treatment studies: A quantitative review. Behavior Research and Therapy 34 1 (1996) 47-51
10. Beck A.T., Ward C.H., Mendelson M., Mock J., and Erbaugh J. An inventory for measuring depression. Archives of General Psychiatry 4 (1961) 561-671
11. Blais M.A., Lenderking W.R., Baer L., deLorell A., Peets K., Leahy L., and Burns C. Development and initial validation of a brief mental health outcome measure. Journal of Personality Assessment 73 (1999) 359-373
12. Burt T., and Ishak W.W. Outcome measurement in mood disorders. In: Ishak W.W., Burt T., and Sederer L.I. (Eds). Outcome measurement in psychiatry (2002), American Psychiatric Publishing, Washington (DC) 164-165
13. Brody A.L., Saxena S., Schwartz J.M., Stoessel P.W., Maidment K., Phelps M.E., and Baxter Jr. L.R. FDG-PET predictors of response to behavioral therapy and pharmacotherapy in obsessive compulsive disorder. Psychiatry Research 84 (1998) 1-6
14. Buchanan A.W., Meng K.S., and Marks I.M. What predicts improvement and compliance during behavioral treatment of obsessive compulsive disorder?. Anxiety 2 (1996) 22-27
15. Carrasco J.L., Hollander E., Schneier F.R., and Liebowitz M.R. Treatment outcome of obsessive compulsive disorder with comorbid social phobia. Journal of Clinical Psychiatry 53 (1992) 387-391
16. Cavedini P., Erzegovesi S., Ronchi P., and Bellodi L. Predictive value of obsessive-compulsive personality disorder in antiobsessional pharmacologic treatment. European Neuropsychpharmacology 7 1 (1997) 45-49
17. Charney D.S., Goodman W.K., Price C.H., Woods S.W., Rasmussen S.A., and Heninger G.R. Serotonin function in obsessive-compulsive disorder: a comparison of the effects of tryptophan and m-chlorophenylpiperazine in patients and healthy subjects. Archives of General Psychiatry 65 (1988) 177-185
18. de Haan E., van Oppen P., van Balkom A.J., Spinhoven P., Hoogduin K.A., and Van Dyck R. Prediction of outcome and early vs. late improvement in OCD patients treated with cognitive behaviour therapy and pharmacotherapy. Acta Psychiatrica Scandinavica 96 (1997) 354-361
19. DeVeaugh-Geiss J., Katz R., Landau P., Goodman W., and Rasmussen S. Clinical predictors of treatment response in obsessive-compulsive disorder: Exploratory analyses from multicenter trials of clomipramine. Psychopharmacology Bulletin 26 1 (1990) 54-59
20. Doge K. Sex difference of rat brain monoamine metabolism under restraint stress. Japanese Journal of Legal Medicine 47 (1993) 46-56
21. Douglass H.M., Moffitt T.E., Dar R., McGee R., and Silva P. Obsessive-compulsive disorder in a birth cohort of 18-year-olds: Prevalence and predictors. Journal of American Academey of Child and Adolescent Psychiatry 34 (1995) 1424-1431
22. Drummond L.M. The treatment of severe, chronic, resistant obsessive-compulsive disorder. British Journal of Psychiatry 163 (1993) 223-229
23. Emmelkamp P.M.G., and Rabbie D.M. Psychological treatment of obsessive-compulsive disorder: A follow-up four years after treatment. In: Perris E., Struwe G., and Jansson B. (Eds). Biological Psychiatry (1981), Elsevier, Amsterdam 1095-1098
24. Erzegovesi S., Cavallini M.C., Cavedini P., Diaferia G., Locatelli M., and Bellodi L. Clinical predictors of drug response in obsessive-compulsive disorder. Journal of Clinical Psychopharmacology 21 5 (2001) 488-492
25. Expert Consensus Treatment Guidelines for OCD. Journal of Clinical Psychiatry 58 Suppl. 4 (1997) 65-72
26. Foa E.B., Grayson J.B., Steketee G.S., Doppelt H.G., Turner R.M., and Latimer P.R. Success and failure in the behavioral treatment of obsessive-compulsives. Journal of Consulting and Clinical Psychology 51 (1983) 287-297
27. Goodman W.K., McDougle C.J., Barr L.C., Aronson S.C., and Price L.H. Biological approaches to treatment-resistant obsessive-compulsive disorder. Journal of Clinical Psychiatry 54 Suppl. 6 (1993) 16-26
28. Goodman W.K., Price L.H., Rasmussen S.A., Mazure C., Delgado P.L., Heninger G.R., and Charney D.S. The Yale-Brown Obsessive Compulsive Scale. II. Validity. Archives of General Psychiatry 46 (1989) 1012-1016
29. Goodman W.K., Price L.H., Rasmussen S.A., Mazure C., Fleischman R.L., Hill C.L., Heninger G.R., and Charney D.S. The Yale-Brown Obsessive Compulsive Scale. I. Development, use and reliability. Archives of General Psychiatry 46 (1989) 1006-1011
30. Harrell F.E., Lee K.L., Matchar D.B., and Reichert T.A. Regression models for prognostic prediction: advantages, problems, and suggested solutions. Cancer Treatment Reports 69 (1985) 1071-1077
31. Hollander E., Stein D.J., Broatch J., Himelein C., and Rowland C. A pharmacoeconomic and quality of life study of obsessive-compulsive disorder. CNS Spectrums 2 (1997) 16-25
32. Hurley R.A., Saxena S., Rauch S.L., Hoehn-Saric R., and Taber K.H. Predicting treatment response in obsessive-compulsive disorder. Journal of Neuropsychiatry and Clinical Neurosciences 14 3 (2002) 249-253
33. Karayiorgou M., Sobin C., Blundell M.L., Galke B.L., Malinova L., Goldberg P., Ott J., and Gogos J.A. Family-based association studies support a sexually-dimorphic effect of COMT and MAOA on genetic susceptibility to obsessive-compulsive disorder. Biological Psychiatry 45 (1999) 1178-1189
34. Karayiorgou M, Altemus M, Galke BL, Goldman D, Murphy DL, Ott J, Gogos JA. Genotype determining low catechol-O-methyltransferase activity as a risk factor for obsessive-compulsive disorder. Paper presented at National Academy of Sciences of the United States of America, 1997.
35. Kaplan H.I., and Sadock B.J. Synopsis of psychiatry. 8th ed. (1998), Williams & Wilkins, Baltimore p. 610
36. Keijsers G.R., Hoogduin C.A., and Schaap C.P. Predictors of treatment outcome in the behavioural treatment of obsessive-compulsive disorder. British Journal of Psychiatry 165 6 (1994) 781-786
37. Koran L.M., Gamel N.N., Choung H.W., Smith E.H., and Aboujaoude E.N. Mirtazapine for obsessive-compulsive disorder: an open trial followed by double-blind discontinuation. Journal of Clinical Psychiatry 66 (2005) 515-520
38. Koran L.M., Ringold A.L., and Elliott M.A. Olanzapine augmentation for treatment-resistant obsessive-compulsive disorder. Journal of Clinical Psychiatry 61 (2000) 514-517
39. Koran L.M., Thienemann M.L., and Davenport R. Quality of life for patients with obsessive-compulsive disorder. American Journal of Psychiatry 153 (1996) 783-788
40. Leonard H.L., Swedo S.E., Lenane M.C., Rettew D.C., Hamburger S.D., Bartko J.J., and Rapoport J.L. A 2- to 7-year follow-up study of 54 obsessive-compulsive children and adolescents. Archives of General Psychiatry 50 6 (1993) 429-439
41. Mallows C.L. Some Comments on C(p). Technometrics 15 (1973) 661-675
42. Mataix-Cols D., Rauch S.L., Manzo P.A., Jenike M.A., and Baer L. Use of factor-analyzed symptom dimensions to predict outcome with serotonin reuptake inhibitors and placebo in the treatment of obsessive-compulsive disorder. American Journal of Psychiatry 156 (1999) 1409-1416
43. Mataix-Cols D., Marks I.M., Greist J.H., Kobak K.A., and Baer L. Obsessive-compulsive symptom dimensions as predictors of compliance with and response to behavior therapy: Results from a controlled trial. Psychotherapy and Psychosomatics 71 (2002) 255-262
44. Mataix-Cols D., Rauch S.L., Baer L., Eisen J.L., Shera D.M., Goodman D.M., Rasmussen S.A., and Jenike M.A. Symptom stability in adult obsessive-compulsive disorder: data from a naturalistic two-year follow-up study. American Journal of Psychiatry 159 (2002) 263-268
45. Mathew S.J., Coplan J.D., Perko K.A., Goetz R.R., de la Neuz M., Hollander E., et al. Neuroendocrine predictors of response to intravenous clomipramine therapy for refractory obsessive-compulsive disorder. Depress Anxiety 14 (2001) 199-208
46. Morault P., Guillem F., Bourgeois M., and Paty J. Improvement predictors in obsessive-compulsive disorder. An event-related potential study. Psychiatry Research 81 (1998) 87-96
47. Mundo E., Bareggi S.R., Pirola R., and Bellodi L. Effect of acute intravenous clomipramine and antiobsessional response to proserotonergic drugs: Is gender a predictive variable?. Biological Psychiatry 45 (1999) 290-294
48. Mundt J., Marks I., Shear M., and Greist J. The Work and Social Adjustment Scale: a simple measure of impairment in functioning. British Journal of Psychiatry 180 (2002) 461-464
49. National Institute of Mental Health. CGI (Clinical Global Impression) Scale-NIMH. Psychopharmacology Bulletin 21 (1985) 839-844
50. Neziroglu F., Pinto A., Yaryura-Tobias J.A., and McKay D. Overvalued ideation as a predictor of fluvoxamine response in patients with obsessive-compulsive disorder. Psychiatry Research 125 (2004) 53-60
51. Piacentini J., Bergman R.L., Jacobs C., McCracken J.T., and Kretchman J. Open trial of cognitive behavior therapy for childhood obsessive-compulsive disorder. Journal of Anxiety Disorders 16 2 (2002) 207-219
52. Pigott T., and Seay S. Pharmacotherapy of OCD. International Review of Psychiatry 9 1 (1997) 133-147
53. Rasmussen S.A., and Eisen J.L. The epidemiology and differential diagnosis of obsessive compulsive disorder. Journal of Clinical Psychiatry 55 Suppl. (1994) 5-10
54. Rauch S.L., Dougherty D.D., Cosgrove G.R., Cassem E.H., Alpert N.M., Price B.H., Nierenberg A.A., Mayberg H.S., Baer L., Jenike M.A., and Fischman A.J. Cerebral metabolic correlates as potential predictors of response to anterior cingulotomy for obsessive compulsive disorder. Biological Psychiatry 50 (2001) 659-667
55. Ravizza L., Barzega G., Bellino S., Bogetto F., and Maina G. Predictors of drug treatment response in obsessive-compulsive disorder. Journal of Clinical Psychiatry 56 8 (1995) 368-373
56. SAS Institute Inc. SAS/STAT User's Guide, Version 8 (1999), STATS Publishing Inc., Cary (NC)
57. Saxena S., Brody A.L., Maidment K.M., Dunkin J.J., Colgan M., Alborzian S., et al. Localized orbitofrontal and subcortical metabolic changes and predictors of response to paroxetine treatment in obsessive-compulsive disorder. Neuropsychopharmacology 21 (1999) 683-693
58. S-PLUS 6.2 for Windows User's Guide. Seattle: Insightful Corporation, 2001.
59. SPSS 12.0 for Windows. Chicago: SPSS Inc., 2003.
60. Stein D.J. Obsessive-Compulsive disorder. Lancet 360 (2002) 397-405
61. Stein D.J., Montgomery S.A., Kasper S., and Tanghoj P. Predictors of response to pharmacotherapy with citalopram in obsessive-compulsive disorder. International Journal of Psychopharmacology 16 6 (2001) 357-361
62. Steiner M, Gergel IP, Wheadon DE. Predictors of response to paroxetine therapy in OCD. Presented at the annual meeting of the American Psychiatric Association: New York, 1996.
63. Steketee G., Chambless D.L., and Tran G.Q. Effects of axis I and II comorbidity on behavior therapy outcome for obsessive-compulsive disorder and agoraphobia. Comprehensive Psychiatry 42 (2001) 76-86
64. Steketee G., and Pigott T. Obsessive-Compulsive Disorder: The latest assessment and treatment strategies (1999), Compact Clinicals, Salt Lake City
65. Steketee G. Disability and family burden in obsessive-compulsive disorder. Canadian Journal of Psychiatry 42 (1997) 919-928
66. Steketee G., Eisen J., Dyck I., Warshaw M., and Rasmussen S. Predictors of course in obsessive-compulsive disorder. Psychiatry Research 89 (1999) 229-238
67. Steketee G. Social support and treatment outcome of obsessive-compulsive disorder at 9-month follow-up. Behavioral Psychotherapy 21 2 (1993) 81-95
68. Stewart S.E., Egan Stack D., Farrell C., Pauls D.L., and Jenike M.A. Effectiveness of intensive residential treatment (IRT) for severe refractory obsessive-compulsive disorder. Journal of Psychiatric Research (2005) 603-609
69. Stewart S.E., Geller D.A., Jenike M.A., Pauls D., Shaw D., Mullin B., and Faraone S.V. Long term outcome of pediatric obsessive compulsive disorder: A meta-analysis and qualitative review of the literature. Acta Psychiatrica Scandinavica 110 1 (2004) 4-13
70. Thase M.E., Reynolds III C.F., Frank E., Simons A.D., McGeary J., Fasiczka A.L., Garamoni G.G., Jennings J.R., and Kupfer D.J. Do depressed men and women respond similarly to cognitive behavior therapy. American Journal of Psychiatry 151 4 (1994) 500-505
71. Thomsen P.H. Obsessive-compulsive disorder in children and adolescents: predictors in childhood for long-term phenomenological course. Acta Psychiatrica Scandinavica 92 4 (1995) 255-259
72. Thornicroft G., Colson L., and Marks I.M. An in-patient behavioural psychotherapy unit. Description and audit. British Journal of Psychiatry 158 (1991) 362-367
73. Willis B.S., Rosqvist J., Egan D., Baney D., and Manzo P. Inpatient and home-based treatment of obsessive-compulsive disorder. In: Jenike M.A., Baer L., and Minichiello W.E. (Eds). Obsessive-compulsive disorders practical management. 3rd ed. (1998), Mosby Inc., St. Louis 583-588
74. Yovel I, Wilhelm S, Gershuny B, et al. The Obsessive-Compulsive Symptoms Rating Inventory: Development and Psychometric Analysis. In: 37th annual convention of the association for the advancement of behavior therapy, Boston, MA, 2003.