Cerebellar fastigial nuclei activity during blood pressure challenges

Journal of Applied Physiology

Volumn 101, Issue 2, 2006, Pages 549-555

  Rector, D M ^b   Richard, C A ^a   Harper, R M ^a  

^a UNIVERSITY OF CALIFORNIA   (United States)

^b WASHINGTON STATE UNIVERSITY   (United States)

Author keywords

Hypertension; Hypotension; Intermittent hypoxia; Obstructive sleep apnea

Indexed keywords

NITROPRUSSIDE SODIUM; PHENYLEPHRINE;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANTIHYPERTENSIVE ACTIVITY; ARTICLE; BLOOD PRESSURE; BLOOD PRESSURE REGULATION; BREATHING RATE; CEREBELLUM; CONTROLLED STUDY; DOSE RESPONSE; EXPERIMENTAL MODEL; FASTIGIAL NUCLEUS; HEART RATE; HYPERTENSION; HYPOTENSION; HYPOXIA; NERVE CELL; NONHUMAN; PRIORITY JOURNAL; RAT; SLEEP APNEA SYNDROME;

ANIMALS; ANOXIA; BLOOD PRESSURE; CEREBELLAR NUCLEI; DOSE-RESPONSE RELATIONSHIP, DRUG; HEART RATE; HYPERTENSION; HYPOTENSION; MALE; NITROPRUSSIDE; PHENYLEPHRINE; RATS; RESPIRATION; SLEEP APNEA, OBSTRUCTIVE; TIME FACTORS; VASOCONSTRICTOR AGENTS; VASODILATOR AGENTS;

EID: 33746777190     PISSN: 87507587     EISSN: 15221601     Source Type: Journal    
DOI: 10.1152/japplphysiol.00044.2006     Document Type: Article

References (41)

1. Batton RR III, Jayaraman A, Ruggiero D, and Carpenter MB. Fastigial efferent projections in the monkey: an autoradiographic study. J Comp Neurol 174: 281-306, 1977.
2. Bradley DJ, Pascoe JP, Paton JFR, and Spyer KM. Cardiovascular and respiratory responses evoked from the posterior cerebellar cortex and fastigial nucleus in the cat. J Physiol 393: 107-121, 1987.
3. Caverson MM, Ciriello J, and Calaresu FR. Direct pathway from cardiovascular neurons in the ventrolateral medulla to the region of the intermediolateral nucleus of the upper thoracic cord: an anatomical and electrophysiological investigation in the cat. J Auton Nerv Syst 9: 451-475, 1983.
4. Chen CH, Williams JL, and Lutherer LO. Cerebellar lesions alter autonomic responses to transient isovolaemic changes in arterial pressure in anaesthetized cats. Clin Auton Res 4: 263-272, 1994.
5. Chen ML, Witmans MB, Tablizo MA, Jubran RF, Turkel SB, Tavare CJ, and Keens TG. Disordered respiratory control in children with partial cerebellar resections. Pediatr Pulmonol 40: 88-91, 2005.
6. Chida K, Iadecola C, Underwood MD, and Reis DJ. A novel vasodepressor response elicited from the rat cerebellar fastigial nucleus: the fastigial depressor response. Brain Res 370: 378-382, 1986.
7. Chida K, Iadecola C, and Reis DJ. Lesions of rostral ventrolateral medulla abolish some cardio- and cerebrovascular components of the cerebellar fastigial pressor and depressor responses. Brain Res 508: 93-104, 1990.
8. Dampney RA, Goodchild AK, Robertson LG, and Montgomery W. Role of the ventrolateral medulla in vasomotor regulation: a correlative anatomical and physiological study. Brain Res 249: 223-235, 1982.
9. Doba N and Reis DJ. Role of the cerebellum and the vestibular apparatus in regulation of orthostatic reflexes in the cat. Circ Res 40: 9-18, 1974.
10. Gozal D, Daniel JM, and Dohanich GP. Behavioral and anatomical correlates of chronic episodic hypoxia during sleep in the rat. J Neurosci 21: 2442-2450, 2001.
11. Gozal E, Sachleben LR Jr, Rane MJ, Vega C, and Gozal D. Mild sustained and intermittent hypoxia induce apoptosis in PC-12 cells via different mechanisms. Am J Physiol Cell Physiol 288: C535-C542, 2005.
12. Harper RM, Macey PM, Henderson LA, Woo MA, Macey KE, Frysinger RC, Alger JR, Nguyen KP, and Yan-Go FL. fMRI responses to cold pressor challenges in control and obstructive sleep apnea subjects. J Appl Physiol 94: 1583-1595, 2003.
13. Harper RM, Richard CA, and Rector DM. Physiological and ventral medullary surface activity during hypovolemia. Neuroscience 94: 579-586, 1999.
14. Henderson LA, Macey PM, Richard CA, Runquist ML, and Harper RM. Functional magnetic resonance imaging during hypotension in the developing animal. J Appl Physiol 97: 2248-2257, 2004.
15. Henderson LA, Richard CA, Macey PM, Runquist ML, Yu PL, Galons JP, and Harper RM. Functional magnetic resonance signal changes in neural structures to baroreceptor reflex activation. J Appl Physiol 96: 693-703, 2004.
16. Hernandez JP, Xu F, and Frazier DT. Medial vestibular nucleus mediates the cardiorespiratory responses to fastigial nuclear activation and hypercapnia. J Appl Physiol 97: 835-842, 2004.
17. Hla KM, Young TB, Bidwell T, Palta M, Skatrud JB, and Dempsey J. Sleep apnea and hypertension: a population-based study. Ann Intern Med 120: 382-388, 1994.
18. Kim AH, Macey PM, Woo MA, Yu PL, Keens TG, Gozal D, and Harper RM. Cardiac responses to pressor challenges in Congenital Central Hypoventilation Syndrome. Somnology 6: 109-115, 2002.
19. Kumar R, Macey PM, Woo MA, Alger JR, Keens TG, and Harper RM. Neuroanatomic deficits in Congenital Central Hypoventilation Syndrome. J Comp Neurol 487: 361-371, 2005.
20. Lutherer LO, Lutherer BC, Dormer HF, Janssen HF, and Barnes CD. Bilateral lesions of the fastigial nucleus prevent the recovery of blood pressure following hypotension induced by hemorrhage or administration of endotoxin. Brain Res 269: 251-257, 1983.
21. Lutherer LO, Williams JL, and Everse SJ. Neurons of the rostral fastigial nucleus are responsive to cardiovascular and respiratory challenges. J Auton Nerv Syst 27: 101-112, 1989.
22. Macey PM, Henderson LA, Macey KE, Alger JR, Frysinger RC, Woo MA, Harper RK, Yan-Go FL, and Harper RM. Brain morphology associated with obstructive sleep apnea. Am J Respir Crit Care Med 166: 1382-1387, 2002.
23. Miura M and Reis DJ. Cerebellum: a pressor response from fastigial nucleus and its efferent pathway in brainstem. Brain Res 13: 595-599, 1969.
24. Pae EK, Chien P, and Harper RM. Intermittent hypoxia damages cerebellar cortex and deep nuclei. Neurosci Lett 375: 123-128, 2005.
25. Parry TJ and McElligott JG. Kainic acid administration in the fastigial nucleus produces differential cardiovascular effects in awake and anesthetized rats. Brain Res 635: 27-36, 1994.
26. Rector DM, Poe GR, Kristensen MP, and Harper RM. Imaging the dorsal hippocampus: light reflectance relationships to electroencephalographic patterns during sleep. Brain Res 696: 151-160, 1995.
27. Rector DM, Poe GR, Redgrave P, and Harper RM. A miniature CCD video camera for high-sensitivity light measurements in freely behaving animals. J Neurosci Methods 78: 85-91, 1997.
28. Rector DM, Roger RF, Schwaber JS, Harper RM, and George JS. Scattered-light imaging in vivo tracks fast and slow processes of neurophysiological activation. Neuroimage 14: 977-994, 2001.
29. Suzuki M, Guilleminault C, Otsuka K, and Shiomi T. Blood pressure "dipping" and "non-dipping" in obstructive sleep apnea syndrome patients. Sleep 19: 382-387, 1996.
30. Sved AF, Scott PJ, and Kole M. Cerebellar lesions attenuate vasopressin release in response to hemorrhage. Neurosci Lett 55: 65-70, 1985.
31. Trelease RB, Sieck GC, Marks JD, and Harper RM. Respiratory inhibition induced by transient hypertension during sleep in unrestrained cats. Exp Neurol 90: 173-186, 1985.
32. Welsh JP, Yuen G, Placantonakis DG, Vu TQ, Haiss F, O'Hearn E, Molliver ME, and Aicher SA. Why do Purkinje cells die so easily after global brain ischemia? Aldolase C, EAAT4, and the cerebellar contribution to posthypoxic myoclonus. Adv Neurol 89: 331-59, 2002.
33. Woo MA, Macey PM, Fonarow GC, Hamilton MA, and Harper RM. Regional brain gray matter loss in heart failure. J Appl Physiol 95: 677-684, 2003.
34. Woo MA, Macey PM, Keens PT, Keens TG, Kumar R, Fonarow GC, Hamilton MA, and Harper RM. Functional abnormalities in brain areas that mediate autonomic nervous system control in advanced heart failure. J Card Fail 11: 437-446, 2005.
35. Xu F and Frazier DT. Respiratory-related neurons of the fastigial nucleus in response to chemical and mechanical challenges. J Appl Physiol 82: 1177-1184, 1997.
36. Xu F and Frazier DT. Modulation of respiratory motor output by cerebellar deep nuclei in the rat. J Appl Physiol 89: 996-1004, 2000.
37. Xu F and Frazier DT. Fastigial nucleus-mediated respiratory responses depend on the medullary gigantocellular nucleus. J Appl Physiol 91: 1713-1722, 2001.
38. Xu F and Frazier DT. Role of the cerebellar deep nuclei in respiratory modulation. Cerebellum 1: 35-40, 2002.
39. Xu F, Zhang Z, and Frazier DT. Microinjection of acetazolamide into the fastigial nucleus augments respiratory output in the rat. J Appl Physiol 91: 2342-2350, 2001.
40. Xu F, Zhou T, and Frazier DT. Purkinje cell degeneration elevates eupneic and hypercapnic ventilation in rats. Cerebellum 3: 133-140, 2004.
41. Yates BJ. Vestibular influences on the autonomic nervous system. Ann NY Acad Sci 781: 458-473, 1996.