Crocetin improves endothelium-dependent relaxation of thoracic aorta in hypercholesterolemic rabbit by increasing eNOS activity

Biochemical Pharmacology

Volumn 72, Issue 5, 2006, Pages 558-565

  Tang, F T ^a,b   Qian, Z Y ^a   Liu, P Q ^b   Zheng, S G ^a   He, S Y ^a   Bao, L P ^b   Huang, H Q ^b  

^a CHINA PHARMACEUTICAL UNIVERSITY   (China)

^b SUN YAT SEN UNIVERSITY   (China)

Author keywords

Bovine aortic endothelial cells; Crocetin; Endothelial nitric oxide synthase; Nitric oxide; Oxidized low density lipoprotein; Vascular relaxation function

Indexed keywords

ACETYLCHOLINE; CYCLIC GMP; ENDOTHELIAL NITRIC OXIDE SYNTHASE; INDUCIBLE NITRIC OXIDE SYNTHASE; NITRIC OXIDE; NITROPRUSSIDE SODIUM; OXIDIZED LOW DENSITY LIPOPROTEIN;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; CHOLESTEROL DIET; CONTROLLED STUDY; DOSE RESPONSE; DOWN REGULATION; ENDOTHELIAL DYSFUNCTION; ENDOTHELIUM CELL; ENZYME ACTIVITY; GENE EXPRESSION; HYPERCHOLESTEROLEMIA; IN VITRO STUDY; IN VIVO STUDY; MALE; NONHUMAN; PRIORITY JOURNAL; RABBIT; THORACIC AORTA; UPREGULATION; VASODILATATION;

ANIMALS; AORTA, ABDOMINAL; AORTA, THORACIC; BASE SEQUENCE; CAROTENOIDS; CYCLIC GMP; DNA PRIMERS; ENDOTHELIUM, VASCULAR; HYPERCHOLESTEROLEMIA; MALE; MUSCLE RELAXATION; NITRIC OXIDE; NITRIC OXIDE SYNTHASE TYPE III; RABBITS; RNA, MESSENGER;

EID: 33746732180     PISSN: 00062952     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.bcp.2006.05.018     Document Type: Article

References (23)

1. Moncada S., Palmer R.M., and Higgs E.A. Nitric oxide: physiology, pathophysiology, and pharmacology. Pharmacol Rev 43 (1991) 109-142
2. Jimenez A., Arriero M.M., Lopez-Blaya A., Gonzalez-Fernandez F., Garcia R., Fortes J., et al. Regulation of endothelial nitric oxide synthase expression in the vascular wall and in mononuclear cells from hypercholesterolemic rabbits. Circulation 104 (2001) 1822-1830
3. Runnie I., Salleh M.N., Mohamed S., Head R.J., and Abeywardena M.Y. Vasorelaxation induced by common edible tropical plant extracts in isolated rat aorta and mesenteric vascular bed. J Ethnopharmacol 92 (2004) 311-316
4. Verburen T.J., Jordens F.H., Zonnekeyn L.L., VanHove C.E., Coene M.C., and Herman A.G. Effect of hypercholesterolemia on vascular reactivity in the rabbit. Circ Res 58 (1986) 552-564
5. Zeiher A.M., Drexler H., Wollschlager H., and Just H. Endothelial dysfunction of the coronary microvasculature is associated with coronary blood flow regulation in patients with early atherosclerosis. Circulation 84 (1991) 1984-1992
6. Zeiher A.M., Drexler H., Saurbier B., and Just H. Endothelium-mediated coronary blood flow modulation in humans. Effects of age, atherosclerosis, hypercholesterolemia, and hypertension. J Clin Invest 92 (1993) 652-662
7. Keaney Jr. J.F., Xu A., Cunningham D., Jackson T., Frei B., and Vita J.A. Dietary probucol preserves endothelial function in cholesterol-fed rabbits by limiting vascular oxidative stress and superoxide generation. J Clin Invest 95 (1995) 2520-2529
8. Kang S.Y., Kim S.H., Schini V.B., and Kim N.D. Dietary ginsenosides improve endothelium-dependent relaxation in the thoracic aorta of hypercholesterolemic rabbit. Gen Pharmacol 26 (1995) 483-487
9. Moncada S., and Higgs A. The l-arginine-nitric oxide pathway. N Engl J Med 329 (1993) 2002-2012
10. Sessa W.C. The nitric oxide synthase family of proteins. J Vasc Res 31 (1994) 131-143
11. Ooboshi H., Toyoda K., Faraci F.M., Lang M.G., and Heistad D.D. Improvement of relaxation in an atherosclerotic artery by gene transfer of endothelial nitric oxide synthase. Arterioscler Thromb Vasc Biol 18 (1998) 1752-1758
12. Cayatte A.J., Palacino J.J., Horten K., and Cohen R.A. Chronic inhibition of nitric oxide production accelerates neointimal formation and impairs endothelial function in hypercholesterolemic rabbits. Arterioscler Thromb 14 (1994) 753-759
13. Liao J.K., Shin W.S., Lee W.Y., and Clark S.L. Oxidized low-density lipoprotein decreases the expression of endothelial nitric oxide synthase. J Biol Chem 270 (1995) 319-324
14. Cominacini L., Pasini A.F., Garbin U., Davoli A., Tosetti M.L., Campagnola M., et al. Oxidized low density lipoprotein (ox-LDL) binding to ox-LDL receptor-1 in endothelial cells induces the activation of NF-kappaB through an increased production of intracellular reactive oxygen species. J Biol Chem 275 (2000) 12633-12638
15. Tseng T.H., Chu C.Y., Huang J.M., Shiow S.J., and Wang C.J. Crocetin protects against oxidative damage in rat primary hepatocytes. Cancer Lett 97 (1995) 61-67
16. Deng Y.X., Qian Z.Y., and Tang F.T. Effects of crocetin on experimental atherosclerosis in rats. Chin Tradition Herbal Drugs 35 (2004) 777-781
17. Zheng S., Qian Z., Tang F., and Sheng L. Suppression of vascular cell adhesion molecule-1 expression by crocetin contributes to attenuation of atherosclerosis in hypercholesterolemic rabbits. Biochem Pharmacol 70 (2005) 1192-1199
18. Zheng S., Qian Z., Sheng L., and Wen N. Crocetin attenuates atherosclerosis in hyperlipidemic rabbits through inhibition of LDL oxidation. J Cardiovasc Pharmacol 47 (2006) 70-76
19. Hattori Y., Kawasaki H., Abe K., and Kanno M. Superoxide dismutase recovers altered endothelium-dependent relaxation in diabetic rat aorta. Am J Physiol 261 (1991) H1086-H1094
20. Guerra Jr. R., Brotherton A.F., Goodwin P.J., Clark C.R., Armstrong M.L., and Harrison D.G. Mechanisms of abnormal endothelium-dependent vascular relaxation in atherosclerosis: implications for altered autocrine and paracrine functions of EDRF. Blood Vessel 26 (1989) 300-314
21. Osborne J.A., Siegman M.J., Sedar A.W., Mooers S.U., and Lefer A.M. Lack of endothelium-dependent relaxation in coronary resistance arteries of cholesterol-fed rabbits. Am J Physiol 256 (1989) C591-C597
22. Simon B.C., Cunningham L.D., and Cohen R.A. Oxidized low density lipoproteins cause contraction and inhibit endothelium-dependent relaxation in the pig coronary artery. J Clin Invest 86 (1990) 75-79
23. Mehta J.L., Li D.Y., Chen H.J., Joseph J., and Romeo F. Inhibition of LOX-1 by statins may relate to upregulation of eNOS. Biochem Biophys Res Commun 289 (2001) 857-861