A new approach to correct the QT interval for changes in heart rate using a nonparametric regression model in beagle dogs

Journal of Pharmacological and Toxicological Methods

Volumn 53, Issue 3, 2006, Pages 234-241

  Watanabe, Hiroyuki ^a   Miyazaki, Hiroyasu ^a  

^a BANYU PHARMACEUTICAL CO LTD   (Japan)

Author keywords

Nonparametric regression model; QT prolongation; QTc

Indexed keywords

ANIMAL EXPERIMENT; ARTICLE; CORRELATION ANALYSIS; DOG; FEMALE; HEART RATE; HEART RATE VARIABILITY; LINEAR REGRESSION ANALYSIS; MALE; MATHEMATICAL MODEL; NONHUMAN; NONPARAMETRIC TEST; QT INTERVAL; REGRESSION ANALYSIS; RR INTERVAL; ANIMAL; BIOLOGICAL MODEL; COMPARATIVE STUDY; DRUG EFFECT; ELECTROCARDIOGRAPHY; LONG QT SYNDROME; ORAL DRUG ADMINISTRATION; PATHOPHYSIOLOGY; PHYSIOLOGY; STATISTICAL MODEL; TELEMETRY;

CANIS FAMILIARIS;

METHYLCELLULOSE;

ADMINISTRATION, ORAL; ANIMALS; DOGS; ELECTROCARDIOGRAPHY; HEART RATE; LINEAR MODELS; LONG QT SYNDROME; MALE; METHYLCELLULOSE; MODELS, BIOLOGICAL; STATISTICS, NONPARAMETRIC; TELEMETRY;

EID: 33746700253     PISSN: 10568719     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.vascn.2005.09.003     Document Type: Article

References (17)

1. Akaike H. A new look at the statistical model identification. IEEE Transactions on Automatic Control, AC 19 (1974) 716-723
2. Batey A.J., and Doe C.P.A. A method for QT correction based on beat-to-beat analysis of the QT/RR interval relationship in conscious telemetred beagle dogs. Journal of Pharmacological and Toxicology Methods 48 (2002) 11-19
3. Bazett H.C. An analysis of the time-relations of electrocardiograms. Heart 7 (1920) 353-370
4. Cleveland W.S., Devlin S.J., and Grosse E. Regression by local fitting: Methods, properties, and computational algorithms. Journal of Econometrics 37 (1998) 87-114
5. Davey P. How to correct the QT interval for the effects of heart rate in clinical studies. Journal of Pharmacological and Toxicology Methods 48 (2002) 3-9
6. Fridericia L.S. Die systolendauer im electrokardiogramm bei normalen menschen und bei herzkranken. Acta Medica Scandinavica 53 (1920) 469-486
7. Hammond T.G., Carlsson L., Davis A.S., Lynch W.G., MacKenzie I., Redfern W.S., et al. Methods of collecting and evaluating non-clinical cardiac electrophysiology data in the pharmaceutical industry: Results of an international survey. Cardiovascular Research 49 (2001) 741-750
8. Hanton G., Nahas K., Priou C., Rabemampianina Y., and Baneux P. The QT interval in the dog ECG: Importance in preclinical toxicology and relationship to heart rate. Toxicology Methods 11 (2001) 21-40
9. Hurvich C.M., and Simonoff J.S. Smoothing parameter selection in nonparametric regression using an improved Akaike Information Criterion. Journal of the Royal Statistical Society, B 60 (1998) 271-293
10. Malik M., Farbom P., Batchvarov V., Hnatkova K., and Camm A.J. Relation between QT and RR intervals is highly individual among healthy subjects: Implications for heart rate correction of the QT interval. Heart 87 (2002) 220-228
11. Matsunaga T., Mitsui T., Harada T., Inokuma M., Murano H., and Shibutani Y. QT corrected for heart rate and relation between QT and RR intervals in beagle dogs. Journal of Pharmacological and Toxicological Methods 38 (1998) 201-209
12. Miyazaki H., Kajiwara H., Nishida M., Sasaki K., Matumoto H., and Watanabe H. Canine telemetry assay: QT-adjustment for changes in heart rate using QT-RR model with unequal slopes and sensitivity to detect drug-induced changes in QT interval. Cardiovascular Risk Assessment Workshop (International Life Science Institute and Health and Environmental Science Institute) 31 (2003)
13. Miyazaki H., and Tagawa M. Rate-correction technique for QT interval in long-term telemetry ECG recording in beagle dogs. Experimental Animals 51 (2002) 465-475
14. SAS Institute Inc. SAS/INSIGHT® User's Guide, Version 8 (1999), SAS Institute Inc., Cary, NC, USA
15. SAS Institute Inc. SAS/STAT® User's Guide, Version 8 (1999), SAS Institute Inc., Cary, NC, USA
16. Shah A., and Hajian G. A maximum likelihood approach for estimating the QT correction factor using mixed effects model. Statistic in Medicine 22 (2003) 1901-1909
17. Spence S., Soper K., Hoe C.-M., and Coleman J. The heart rate-corrected QT interval of conscious beagle dogs: A formula based on analysis of covariance. Toxicological Sciences 45 (1998) 247-258