Regeneration of megakaryocytopoiesis and thrombopoiesis in vitro from X-irradiated human hematopoietic stem cells

Radiation Research

Volumn 166, Issue 2, 2006, Pages 345-351

  Kashiwakura, Ikuo ^a   Inanami, Osamu ^b   Abe, Yoshinao ^c   Satoh, Kei ^c   Takahashi, Tsuneo A ^d   Kuwabara, Mikinori ^b  

^a HIROSAKI UNIVERSITY   (Japan)

^b HOKKAIDO UNIVERSITY   (Japan)

^c HIROSAKI UNIVERSITY   (Japan)

^d UNIVERSITY OF TOKYO   (Japan)

Author keywords

[No Author keywords available]

Indexed keywords

CD34 ANTIGEN; CYTOKINE; FIBRINOGEN RECEPTOR; FLT3 LIGAND; INTERLEUKIN 3; RECOMBINANT FLT3 LIGAND; RECOMBINANT INTERLEUKIN 3; RECOMBINANT STEM CELL FACTOR; RECOMBINANT THROMBOPOIETIN; STEM CELL FACTOR; THROMBOPOIETIN; UNCLASSIFIED DRUG;

ARTICLE; CELL CULTURE; CELL GROWTH; CELL MATURATION; CELL REGENERATION; CELL SURVIVAL; COLONY FORMING UNIT; CONTROLLED STUDY; CULTURE MEDIUM; HEMATOPOIETIC STEM CELL; HUMAN; HUMAN CELL; IN VITRO STUDY; MEGAKARYOCYTE; MEGAKARYOPOIESIS; PRIORITY JOURNAL; RADIATION EXPOSURE; RADIOSENSITIVITY; THROMBOCYTE; THROMBOCYTOPOIESIS; X IRRADIATION;

ANTIGENS, CD34; BIOLOGICAL MARKERS; BLOOD PLATELETS; CELL DIFFERENTIATION; CELLS, CULTURED; HEMATOPOIETIC STEM CELLS; HUMANS; MEGAKARYOCYTES; PLATELET ACTIVATION; THROMBOPOIESIS; X-RAYS;

EID: 33746626485     PISSN: 00337587     EISSN: None     Source Type: Journal    
DOI: 10.1667/RR3595.1     Document Type: Article

References (30)

1. A. Haimovitz-Friedman, Radiation-induced signal transduction and stress response. Radiat. Res. 150 (Suppl.), S102-S108 (1998).
2. E. G. Wright, Radiation-induced genomic instability in haemopoietic cells. Int. J. Radiat. Biol. 74, 681-687 (1998).
3. R. K. Schmidt-Ullrich, P. Dent, S. Grant, R. B. Mikkelsen and K. Valerie, Signal transduction and cellular radiation responses. Radiat. Res. 153, 245-257 (2000).
4. H. Nagayama, K. Misawa, H. Tanaka, J. Ooi, T. Iseki, A. Tojo, K. Tani, Y. Yamada, H. Kodo and S. Asano, Transient hematopoietic stem cell rescue using umbilical cord blood for a lethally irradiated nuclear accident victim. Bone Marrow Transplant. 29, 197-204 (2002).
5. W. S. Armstrong and P. Kazanjian, Use of cytokines in human immunodeficiency virus-infected patients: Colony-stimulating factors, erythropoietin, and interleukin-2. Clin. Infect. Dis. 32, 766-773 (2001).
6. S. K. Parsons, Oncology practice patterns in the use of hematopoietic growth factors. Curr. Opin. Pediatr. 12, 10-17 (2000).
7. P. Rebulla, Refractoriness to platelet transfusion. Curr. Opin. Hematol. 9, 516-520 (2002).
8. C. R. Bachier, E. Gokmen, J. Teale, S. Lanzkron, C. Childs, W. Franklin, E. Shpall, J. Douville, S. Weber and C. F. LeMaistre, Ex vivo expansion of bone marrow progenitor cells for hematopoietic reconstitution following high dose chemotherapy for breast cancer. Exp. Hematol. 27, 615-623 (1999).
9. I. McNiece, R. Jones, S. I. Bearman, P. Cagnoni, Y. Nieto, W. Franklin, J. Ryder, A. Steele, J. Stoltz and E. J. Shpall, Ex vivo expanded peripheral blood progenitor cells provide rapid neutrophil recovery after high-dose chemotherapy in patients with breast cancer. Blood 96, 3001-3007 (2002).
10. R. L. Paquette, S. T. Dergham, E. Karpf, H. J. Wang, D. J. Slamon, L. Souza and J. A. Glaspy, Culture conditions affect the ability of ex vivo expanded peripheral blood progenitor cells to accelerate hematopoietic recovery. Exp. Hematol. 30, 374-380 (2002).
11. I. Kashiwakura, M. Kuwabara, O. Inanami, M. Murakami, Y. Hayase, T. A. Takahashi and Y. Takagi, Radiation sensitivity of megakaryocyte colony forming cells in human placental and umbilical cord blood. Radiat. Res. 153, 144-152 (2000).
12. + megakaryocytic progenitor cells from normal human peripheral blood. Radiat. Res. 158, 202-209 (2002).
13. + megakaryocytic progenitor cells from human placental and umbilical cord blood. Radiat. Res. 160, 210-216 (2003).
14. S. Siena, M. Bregni, L. Bonsi, I. Sklenar, G. P. Bagnara, G. Bonadonna and A. M. Gianni, Increase in peripheral blood megakaryocyte progenitors following cancer therapy with high dose cyclophosphamide and hematopoietic growth factors. Exp. Hematol. 21, 1583-1590 (1993).
15. T. Hagiwara, I. Kodama, K. Hone, T. Kato and H. Miyazaki, Proliferative properties of human umbilical cord blood megakaryocyte progenitor cells to human thrombopoietin. Exp. Hematol. 26, 228-235 (1998).
16. I. A. Hagberg and T. Lyberg, Evaluation of circulating platelet-leukocyte conjugates: A sensitive flow cytometric assay well suited for clinical studies. Platelets 11, 151-160 (2000).
17. I. Kashiwakura and T. A. Takahashi, Basic fibroblast growth factor-stimulated ex vivo expansion of hematopoietic progenitor cells from human placental and umbilical cord blood. Br. J. Haematol. 122, 479-488 (2003).
18. + hematopoietic progenitor cells. Radiat. Res. 147, 61-69 (1997).
19. R. L. Basser, J. E. Rasko, K. Clarke, J. Cebon, M. D. Green, A. P. Grigg, J. Zalcberg, B. Cohen, J. O'Byrne and C. G. Begley, Randomized, blinded, placebo-controlled phase I trial of pegylated recombinant human megakaryocyte growth and development factor with filgrastim after dose-intensive chemotherapy in patients with advanced cancer. Blood 89, 3118-3128 (1997).
20. + hematopoietic progenitor cells. Int. J. Radiat. Oncol. Biol. Phys. 40, 1193-1203 (1998).
21. H. Miyazaki and T. Kato, Thrombopoietin: biology and clinical potentials. Int. J. Hematol. 70, 216-225 (1999).
22. S. Vadhan-Raj, Clinical experience with recombinant human thrombopoietin in chemotherapy-induced thrombocytopenia. Semin. Hematol. 37 (Suppl.), 28-34 (2000).
23. R. Basser, Clinical biology and potential use of thrombopoietin. Can. J. Gastroenterol. 14 (Suppl. D), 73D-78D (2000).
24. J. P. Chute, J. Fung, G. Muramoto and R. Erwin, Ex vivo culture rescues hematopoietic stem cells with long-term repopulating capacity following harvest from lethally irradiated mice. Exp. Hematol. 32, 308-317 (2004).
25. Y. Belkacemi, S. Bouchet, J. Frick, A. Huchet, F. Pene, J. Aigueperse, P. Gourmelon, M. Lopez and N. C. Gorin, Monitoring of residual hematopoiesis after total body irradiation in humans as a model for accidental X-ray exposure: dose-effect and failure of ex vivo expansion of residual stem cells in view of autografting. Int. J. Radiat. Oncol. Biol. Phys. 57, 500-507 (2003).
26. F. Herodin, P. Bourin, J. F. Mayol, J. J. Lataillade and M. Drouet, Short-term injection of antiapoptotic cytokine combinations soon after lethal gamma-irradiation promotes survival. Blood 101, 2609-2616 (2003).
27. M. Drouet, F. Mourcin, N. Grenier, V. Leroux, J. Denis, J. F. Mayol, P. Thullier, J. J. Lataillade and F. Herodin, Single administration of stem cell factor, FLT-3 ligand, megakaryocyte growth and development factor, and interleukin-3 in combination soon after irradiation prevents nonhuman primates from myelosuppression: long-term follow-up of hematopoiesis. Blood 103, 878-885 (2004).
28. J. M. Bertho, J. Frick, C. Demarquay, A. Lauby, E. Mathieu, N. Dudoignon, N. Jacquet, F. Trompier, A. Chapel and D. Thierry, Re-injection of ex vivo-expanded primate bone marrow mononuclear cells strongly reduces radiation-induced aplasia. J. Hematother. Stem Cell Res. 11, 549-564 (2002).
29. E. S. Choi, J. L. Nichol, M. M. Hokom, A. C. Hornkohl and P. Hunt, Platelets generated in vitro from proplatelet-displaying human megakaryocytes are functional. Blood 85, 402-413 (1995).
30. + progenitor cells to study transgenes in the platelet environment. Circ. Res. 95, e36-44 (2004).