An HPLC chromatographic reactor approach for investigating the hydrolytic stability of a pharmaceutical compound

Journal of Pharmaceutical and Biomedical Analysis

Volumn 41, Issue 3, 2006, Pages 883-890

  Skrdla, Peter J ^a   Abrahim, Ahmed ^a   Wu, Yan ^a  

^a MERCK RESEARCH LABORATORIES   (United States)

Author keywords

Aprepitant; Chromatographic reactor; Degradation kinetics; Emend; Fosaprepitant Dimeglumine; HPLC; On column reaction; Stability testing

Indexed keywords

ACETONITRILE; APREPITANT; FOSAPREPITANT DIMEGLUMINE; MEGLUMINE; PHOSPHORIC ACID; PRODRUG; UNCLASSIFIED DRUG; DRUG;

ACCURACY; ARTICLE; COLUMN CHROMATOGRAPHY; DRUG DEGRADATION; DRUG DETERMINATION; DRUG HYDROLYSIS; DRUG IMPURITY; DRUG SOLUBILITY; DRUG SOLUTION; DRUG STABILITY; ELUTION; ENERGY; FEASIBILITY STUDY; HIGH PERFORMANCE LIQUID CHROMATOGRAPHY; MATHEMATICAL COMPUTING; PRIORITY JOURNAL; REACTOR; VALIDATION PROCESS; CHEMISTRY; HYDROLYSIS; KINETICS; METHODOLOGY; THERMODYNAMICS;

CHROMATOGRAPHY, HIGH PRESSURE LIQUID; HYDROLYSIS; KINETICS; PHARMACEUTICAL PREPARATIONS; THERMODYNAMICS;

EID: 33746578595     PISSN: 07317085     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.jpba.2006.02.005     Document Type: Article

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