메뉴 건너뛰기




Volumn 20, Issue 9, 2006, Pages 1387-1395

Reactive oxygen species mediates disialoganglioside GD3-induced inhibition of ERK1/2 and matrix metalloproteinase-9 expression in vascular smooth muscle cells

Author keywords

Atherosclerosis; Cell cycle; GD3 synthase gene; NAC; PDTC

Indexed keywords

ACETYLCYSTEINE; ACTIVATING PROTEIN 1; GANGLIOSIDE GD3; GD3 GANGLIOSIDE SYNTHASE; GELATINASE B; HYDROGEN PEROXIDE; IMMUNOGLOBULIN ENHANCER BINDING PROTEIN; MITOGEN ACTIVATED PROTEIN KINASE 1; MITOGEN ACTIVATED PROTEIN KINASE 3; PEPTIDES AND PROTEINS; PLATELET DERIVED GROWTH FACTOR; PYRROLIDINE DITHIOCARBAMATE; REACTIVE OXYGEN METABOLITE; SUPEROXIDE; SUPEROXIDE DISMUTASE; SYNTHETASE; TUMOR NECROSIS FACTOR ALPHA; GANGLIOSIDE; GANGLIOSIDE, GD3; GLUTATHIONE; MITOCHONDRIAL DNA; PRIMER DNA;

EID: 33746555652     PISSN: 08926638     EISSN: None     Source Type: Journal    
DOI: 10.1096/fj.05-4618com     Document Type: Article
Times cited : (30)

References (50)
  • 1
    • 0027241856 scopus 로고
    • The pathogenesis of atherosclerosis: A perspective for the 1990s
    • Ross, R. (1993) The pathogenesis of atherosclerosis: a perspective for the 1990s. Nature 362, 801-809
    • (1993) Nature , vol.362 , pp. 801-809
    • Ross, R.1
  • 2
    • 0032964803 scopus 로고    scopus 로고
    • Epigallocathechin-3 gallate selectively inhibits the PDGF-BB-induced intracellular signaling transduction pathway in vascular smooth muscle cells and inhibits transformation of sis-transfected NIH 3T3 fibroblasts and human glioblastoma cells (A172)
    • Ahn, H. Y., Hadizadeh, K. R., Seul, C., Yun, Y. P., Vetter, H., and Sachinidis, A. (1999) Epigallocathechin-3 gallate selectively inhibits the PDGF-BB-induced intracellular signaling transduction pathway in vascular smooth muscle cells and inhibits transformation of sis-transfected NIH 3T3 fibroblasts and human glioblastoma cells (A172). Mol. Biol. Cell. 10, 1093-1104
    • (1999) Mol. Biol. Cell. , vol.10 , pp. 1093-1104
    • Ahn, H.Y.1    Hadizadeh, K.R.2    Seul, C.3    Yun, Y.P.4    Vetter, H.5    Sachinidis, A.6
  • 3
    • 0032918581 scopus 로고    scopus 로고
    • Expression of the AT2 receptor developmentally programs extracellular signal-regulated kinase activity and influences fetal vascular growth
    • Akishita, M., Ito, M., Lehtonen, J. Y., Daviet, L., Dzau, V. J., and Horiuchi, M. (1999) Expression of the AT2 receptor developmentally programs extracellular signal-regulated kinase activity and influences fetal vascular growth. J. Clin. Invest. 103, 63-71
    • (1999) J. Clin. Invest. , vol.103 , pp. 63-71
    • Akishita, M.1    Ito, M.2    Lehtonen, J.Y.3    Daviet, L.4    Dzau, V.J.5    Horiuchi, M.6
  • 4
    • 0033552883 scopus 로고    scopus 로고
    • Atherosclerosis-an inflammatory disease
    • Ross, R. (1999) Atherosclerosis-an inflammatory disease. N. Engl. J. Med. 340, 115-126
    • (1999) N. Engl. J. Med. , vol.340 , pp. 115-126
    • Ross, R.1
  • 5
    • 0025080602 scopus 로고
    • Structure and function of small arteries
    • Mulvany, M .J., and Aalkjaer, C. (1990) Structure and function of small arteries. Physiol. Rev. 70, 921-961
    • (1990) Physiol. Rev. , vol.70 , pp. 921-961
    • Mulvany, M.J.1    Aalkjaer, C.2
  • 6
    • 0028171292 scopus 로고
    • G1 phase progression: Cycling on cue
    • Sherr, C. J. (1994) G1 phase progression: cycling on cue. Cell. 79, 551-555
    • (1994) Cell , vol.79 , pp. 551-555
    • Sherr, C.J.1
  • 7
    • 0029849620 scopus 로고    scopus 로고
    • Cancer cell cycles
    • Sherr, C. J. (1996) Cancer cell cycles. Science 274, 1672-1677
    • (1996) Science , vol.274 , pp. 1672-1677
    • Sherr, C.J.1
  • 8
    • 0028237165 scopus 로고
    • Cytokine-stimulated human vascular smooth muscle cells synthesize a complement of enzymes required for extracellular matrix digestion
    • Galis, Z. S., Muszynski, M., Sukhova, G. K., Simon-Morrissey, E., Unemori, E. N., Lark, W. W., Amento, E., and Libby, P. (1994) Cytokine-stimulated human vascular smooth muscle cells synthesize a complement of enzymes required for extracellular matrix digestion. Circ. Res. 75, 181-189
    • (1994) Circ. Res. , vol.75 , pp. 181-189
    • Galis, Z.S.1    Muszynski, M.2    Sukhova, G.K.3    Simon-Morrissey, E.4    Unemori, E.N.5    Lark, W.W.6    Amento, E.7    Libby, P.8
  • 9
    • 0037459043 scopus 로고    scopus 로고
    • Quercetin exerts multiple inhibitory effects on vascular smooth muscle cells: Role of ERK1/2, cell-cycle regulation, and matrix metalloproteinase-9
    • Moon, S. K., Cho, G. O., Jung, S. Y., Gal, S. W., Kwon, T. K., Lee, Y. C., Madamanchi, N. R., and Kim, C. H. (2003) Quercetin exerts multiple inhibitory effects on vascular smooth muscle cells: role of ERK1/2, cell-cycle regulation, and matrix metalloproteinase-9. Biochem. Biophys. Res. Commun. 301, 1069-1078
    • (2003) Biochem. Biophys. Res. Commun. , vol.301 , pp. 1069-1078
    • Moon, S.K.1    Cho, G.O.2    Jung, S.Y.3    Gal, S.W.4    Kwon, T.K.5    Lee, Y.C.6    Madamanchi, N.R.7    Kim, C.H.8
  • 10
    • 0033663865 scopus 로고    scopus 로고
    • Mitogen-activated protein kinases mediate matrix metalloproteinase-9 expression in vascular smooth muscle cells
    • Cho, A., Graves, J., and Reidy, M. A. (2000) Mitogen-activated protein kinases mediate matrix metalloproteinase-9 expression in vascular smooth muscle cells. Arterioscler. Thromb. Vasc. Biol. 20, 2527-2532
    • (2000) Arterioscler. Thromb. Vasc. Biol. , vol.20 , pp. 2527-2532
    • Cho, A.1    Graves, J.2    Reidy, M.A.3
  • 11
    • 1242317083 scopus 로고    scopus 로고
    • ERK1/2 mediates TNF-alpha-induced matrix metalloproteinase-9 expression in human vascular smooth muscle cells via the regulation of NF-kappaB and AP-1: Involvement of the ras dependent pathway
    • Moon, S. K., Cha, B. Y., and Kim, C. H. (2004) ERK1/2 mediates TNF-alpha-induced matrix metalloproteinase-9 expression in human vascular smooth muscle cells via the regulation of NF-kappaB and AP-1: involvement of the ras dependent pathway. J. Cell. Physiol. 198, 417-427
    • (2004) J. Cell. Physiol. , vol.198 , pp. 417-427
    • Moon, S.K.1    Cha, B.Y.2    Kim, C.H.3
  • 12
    • 0025820624 scopus 로고
    • A role for oxygen radicals as second messengers
    • Schreck, R., and Baeuerle, P. A. (1991) A role for oxygen radicals as second messengers. Trends Cell Biol. 1, 39-42
    • (1991) Trends Cell Biol. , vol.1 , pp. 39-42
    • Schreck, R.1    Baeuerle, P.A.2
  • 14
    • 0030952830 scopus 로고    scopus 로고
    • Redox-regulated signaling by lactosylceramide in the proliferation of human aortic smooth muscle cells
    • Bhunia, A. K., Han, H., Snowden, A., and Chatterjee, S. (1997) Redox-regulated signaling by lactosylceramide in the proliferation of human aortic smooth muscle cells. J. Biol. Chem. 272, 15642-15649
    • (1997) J. Biol. Chem. , vol.272 , pp. 15642-15649
    • Bhunia, A.K.1    Han, H.2    Snowden, A.3    Chatterjee, S.4
  • 15
    • 0027363967 scopus 로고
    • Human disease, free radicals, and the oxidant/antioxidant balance
    • McCord, J. M. (1993) Human disease, free radicals, and the oxidant/antioxidant balance. Clin. Biochem. 26, 351-357
    • (1993) Clin. Biochem. , vol.26 , pp. 351-357
    • McCord, J.M.1
  • 18
    • 0031032817 scopus 로고    scopus 로고
    • Mitochondrial DNA damage is more extensive and persists longer than nuclear DNA damage in human cells following oxidative stress
    • Yakes, F. M., Van Houten, B. (1997) Mitochondrial DNA damage is more extensive and persists longer than nuclear DNA damage in human cells following oxidative stress. Proc. Natl. Acad. Sci. U. S. A. 94, 514-519
    • (1997) Proc. Natl. Acad. Sci. U. S. A. , vol.94 , pp. 514-519
    • Yakes, F.M.1    Van Houten, B.2
  • 19
    • 0028927261 scopus 로고
    • Reactions of oxyl radicals with DNA
    • Breen, A. P., and Murphy, J. A. (1995) Reactions of oxyl radicals with DNA. Free Radical Biol. Med. 18, 1033-1077
    • (1995) Free Radical Biol. Med. , vol.18 , pp. 1033-1077
    • Breen, A.P.1    Murphy, J.A.2
  • 20
    • 0027429271 scopus 로고
    • Reactions of oxyl radicals with DNA
    • Hakomori, S., and Igarashi, Y. (1993) Reactions of oxyl radicals with DNA. Adv. Lipid Res. 25, 147-162
    • (1993) Adv. Lipid Res. , vol.25 , pp. 147-162
    • Hakomori, S.1    Igarashi, Y.2
  • 21
    • 0031694479 scopus 로고    scopus 로고
    • Sphingolipids in atherosclerosis and vascular biology
    • Chatterjee, S. (1998) Sphingolipids in atherosclerosis and vascular biology. Arterioscler. Thromb. Vasc. Biol. 18, 1523-1533
    • (1998) Arterioscler. Thromb. Vasc. Biol. , vol.18 , pp. 1523-1533
    • Chatterjee, S.1
  • 22
    • 0020003718 scopus 로고
    • GD3, a prominent ganglioside of human melanoma. Detection and characterisation by mouse monoclonal antibody
    • Pukel, C. S., Lloyd, K. O., Travassos, L. R., Dippold, W. G., Oettgen, H. F., and Old, L. J. (1982) GD3, a prominent ganglioside of human melanoma. Detection and characterisation by mouse monoclonal antibody. J. Exp. Med. 155, 1133-1147
    • (1982) J. Exp. Med. , vol.155 , pp. 1133-1147
    • Pukel, C.S.1    Lloyd, K.O.2    Travassos, L.R.3    Dippold, W.G.4    Oettgen, H.F.5    Old, L.J.6
  • 23
    • 0037427413 scopus 로고    scopus 로고
    • Redox regulation and signaling lipids in mitochondrial apoptosis
    • Fernández-Checa, J. C. (2003) Redox regulation and signaling lipids in mitochondrial apoptosis. Biochem. Biophys. Res. Commun. 304, 471-479
    • (2003) Biochem. Biophys. Res. Commun. , vol.304 , pp. 471-479
    • Fernández-Checa, J.C.1
  • 24
    • 0343883506 scopus 로고    scopus 로고
    • Direct interaction of GD3 ganglioside with mitochondria generates reactive oxygen species followed by mitochondrial permeability transition, cytochrome c release, and caspase activation
    • García-Ruiz, C., Colell, A., Paris, R., and Fernández- Checa, J. C. (2000) Direct interaction of GD3 ganglioside with mitochondria generates reactive oxygen species followed by mitochondrial permeability transition, cytochrome c release, and caspase activation. FASEB J. 14, 847-858
    • (2000) FASEB J. , vol.14 , pp. 847-858
    • García-Ruiz, C.1    Colell, A.2    Paris, R.3    Fernández-Checa, J.C.4
  • 27
    • 0141483378 scopus 로고    scopus 로고
    • Cholesterol impairs the adenine nucleotide translocator-mediated mitochondrial permeability transition through altered membrane fluidity
    • Colell, A., García-Ruiz, C., Lluis, J. M., Coll, O., Marí, M., and Fernández-Checa, J. C. (2003) Cholesterol impairs the adenine nucleotide translocator-mediated mitochondrial permeability transition through altered membrane fluidity. J. Biol. Chem. 278, 33928-33935
    • (2003) J. Biol. Chem. , vol.278 , pp. 33928-33935
    • Colell, A.1    García-Ruiz, C.2    Lluis, J.M.3    Coll, O.4    Marí, M.5    Fernández-Checa, J.C.6
  • 28
    • 0028229899 scopus 로고
    • Effect of chronic ethanol feeding on glutathione and functional integrity of mitochondria in periportal and perivenous rat hepatocytes
    • García-Ruiz, C., Morales, A., Ballesta, A., Rodés, J., Kaplowitz, N., and Fernández-Checa, J. C. (1994) Effect of chronic ethanol feeding on glutathione and functional integrity of mitochondria in periportal and perivenous rat hepatocytes. J. Clin. Invest. 94, 193-201
    • (1994) J. Clin. Invest. , vol.94 , pp. 193-201
    • García-Ruiz, C.1    Morales, A.2    Ballesta, A.3    Rodés, J.4    Kaplowitz, N.5    Fernández-Checa, J.C.6
  • 29
    • 0027475992 scopus 로고
    • Selective depletion of mitochondrial glutathione concentrations by (R,S)-3-hydroxy-4-pentenoate potentiates oxidative cell death
    • Shan, X., Jones, D. P., Hashmi, M., and Anders, M. W. (1993) Selective depletion of mitochondrial glutathione concentrations by (R,S)-3-hydroxy-4- pentenoate potentiates oxidative cell death. Chem. Res. Toxicol. 6, 75-81
    • (1993) Chem. Res. Toxicol. , vol.6 , pp. 75-81
    • Shan, X.1    Jones, D.P.2    Hashmi, M.3    Anders, M.W.4
  • 30
    • 0037237733 scopus 로고    scopus 로고
    • Defective TNF-alpha-mediated hepatocellular apoptosis and liver damage in acidic sphingomyelinase knockout mice
    • García-Ruiz, C., Colell, A., Mari, M., Morales, A., Calvo, M., Enrich, C., and Fernández-Checa, J. C. (2003) Defective TNF-alpha-mediated hepatocellular apoptosis and liver damage in acidic sphingomyelinase knockout mice. J. Clin. Invest. 111, 197-208
    • (2003) J. Clin. Invest. , vol.111 , pp. 197-208
    • García-Ruiz, C.1    Colell, A.2    Mari, M.3    Morales, A.4    Calvo, M.5    Enrich, C.6    Fernández-Checa, J.C.7
  • 31
    • 0029133738 scopus 로고
    • Glycosphingolipid accumulation in the aortic wall is another feature of human atherosclerosis
    • Mukhin, D., Chao, F. F., and Kruth, H. S. (1995) Glycosphingolipid accumulation in the aortic wall is another feature of human atherosclerosis. Arterioscler. Thromb. Vasc. Biol. 15, 1607-1615
    • (1995) Arterioscler. Thromb. Vasc. Biol. , vol.15 , pp. 1607-1615
    • Mukhin, D.1    Chao, F.F.2    Kruth, H.S.3
  • 32
    • 1842293966 scopus 로고    scopus 로고
    • Accumulation of glycosphingolipids in human atherosclerotic plaque and unaffected aorta tissues
    • Chatterjee, S., Dey, S., Shi, W. Y., Thomas, K., and Hutchins, G. M. (1997) Accumulation of glycosphingolipids in human atherosclerotic plaque and unaffected aorta tissues. Glycobiology 7, 57-65
    • (1997) Glycobiology , vol.7 , pp. 57-65
    • Chatterjee, S.1    Dey, S.2    Shi, W.Y.3    Thomas, K.4    Hutchins, G.M.5
  • 33
    • 0037053401 scopus 로고    scopus 로고
    • GD3 recruits reactive oxygen species to induce cell proliferation and apoptosis in human aortic smooth muscle cells
    • Bhunia, A. K., Schwarzmann, G., and Chatterjee, S. (2002) GD3 recruits reactive oxygen species to induce cell proliferation and apoptosis in human aortic smooth muscle cells. J. Biol. Chem. 277, 16396-16402
    • (2002) J. Biol. Chem. , vol.277 , pp. 16396-16402
    • Bhunia, A.K.1    Schwarzmann, G.2    Chatterjee, S.3
  • 34
    • 4043152144 scopus 로고    scopus 로고
    • Disialoganglioside (GD3) synthase gene expression suppresses vascular smooth muscle cell responses via inhibition of ERK1/2 phosphorylation, cell cycle progression, and matrix metalloproteinase-9 expression
    • Moon, S. K., Kim, H. M., Lee, Y. C., and Kim, C. H. (2004) Disialoganglioside (GD3) synthase gene expression suppresses vascular smooth muscle cell responses via inhibition of ERK1/2 phosphorylation, cell cycle progression, and matrix metalloproteinase-9 expression. J. Biol. Chem. 279, 33063-33070
    • (2004) J. Biol. Chem. , vol.279 , pp. 33063-33070
    • Moon, S.K.1    Kim, H.M.2    Lee, Y.C.3    Kim, C.H.4
  • 35
    • 0034123171 scopus 로고    scopus 로고
    • Interactions of oxidants with vascular signaling systems
    • Wolin, M. S. (2000) Interactions of oxidants with vascular signaling systems. Arterioscler. Thromb. Vasc. Biol. 20, 1430-1442
    • (2000) Arterioscler. Thromb. Vasc. Biol. , vol.20 , pp. 1430-1442
    • Wolin, M.S.1
  • 36
    • 0029017015 scopus 로고
    • Malondialdehyde-modified low density lipoproteins in patients with atherosclerotic disease
    • Holvoet, P., Perez, G., Zhao, Z., Brouwers, E., Bernar, H., and Collen, D. (1995) Malondialdehyde-modified low density lipoproteins in patients with atherosclerotic disease. J. Clin. Invest. 95, 2611-2619
    • (1995) J. Clin. Invest. , vol.95 , pp. 2611-2619
    • Holvoet, P.1    Perez, G.2    Zhao, Z.3    Brouwers, E.4    Bernar, H.5    Collen, D.6
  • 38
    • 0029609895 scopus 로고
    • Functional role of glycosphingolipids in cell recognition and signaling
    • Hakomori, S., and Igarashi, Y. (1995) Functional role of glycosphingolipids in cell recognition and signaling. J. Biochem. (Tokyo) 118, 1091-1103
    • (1995) J. Biochem. (Tokyo) , vol.118 , pp. 1091-1103
    • Hakomori, S.1    Igarashi, Y.2
  • 39
    • 0029819129 scopus 로고    scopus 로고
    • Gangliosides GM1, GM2 and GM3 inhibit the platelet-derived growth factor-induced signalling transduction pathway in vascular smooth muscle cells by different mechanisms
    • Sachinidis, A., Kraus, R., Seul, C., Meyer zu Brickwedde M. K., Schulte, K., Ko, Y., Hoppe, J., and Vetter, H. (1996) Gangliosides GM1, GM2 and GM3 inhibit the platelet-derived growth factor-induced signalling transduction pathway in vascular smooth muscle cells by different mechanisms. Eur. J. Cell Biol. 71, 79-88
    • (1996) Eur. J. Cell Biol. , vol.71 , pp. 79-88
    • Sachinidis, A.1    Kraus, R.2    Seul, C.3    Meyer Zu Brickwedde, M.K.4    Schulte, K.5    Ko, Y.6    Hoppe, J.7    Vetter, H.8
  • 40
    • 0035725995 scopus 로고    scopus 로고
    • Gangliosides GM1 and GM2 induce vascular smooth muscle cell proliferation via extracellular signal-regulated kinase 1/2 pathway
    • Gouni-Berthold, I., Seul, C., Ko, Y., Hescheler, J., and Sachinidis, A. (2001) Gangliosides GM1 and GM2 induce vascular smooth muscle cell proliferation via extracellular signal-regulated kinase 1/2 pathway. Hypertension. 38, 1030-1037
    • (2001) Hypertension , vol.38 , pp. 1030-1037
    • Gouni-Berthold, I.1    Seul, C.2    Ko, Y.3    Hescheler, J.4    Sachinidis, A.5
  • 41
    • 1842330849 scopus 로고    scopus 로고
    • Direct effect of ceramide on the mitochondrial electron transport chain leads to generation of reactive oxygen species. Role of mitochondrial glutathione
    • Garcia-Ruiz, C., Colell, A., Mari, M., Morales, A., and Fernandez-Checa, J. C. (1997) Direct effect of ceramide on the mitochondrial electron transport chain leads to generation of reactive oxygen species. Role of mitochondrial glutathione. J. Biol. Chem. 272, 11369-11377
    • (1997) J. Biol. Chem. , vol.272 , pp. 11369-11377
    • Garcia-Ruiz, C.1    Colell, A.2    Mari, M.3    Morales, A.4    Fernandez-Checa, J.C.5
  • 43
    • 0028365310 scopus 로고
    • Angiotensin II stimulates NADH and NADPH oxidase activity in cultured vascular smooth muscle cells
    • Griendling, K. K., Minieri, C. A., Ollerenshaw, J. D., and Alexander, R. W. (1994) Angiotensin II stimulates NADH and NADPH oxidase activity in cultured vascular smooth muscle cells. Circ. Res. 74, 1141-1148
    • (1994) Circ. Res. , vol.74 , pp. 1141-1148
    • Griendling, K.K.1    Minieri, C.A.2    Ollerenshaw, J.D.3    Alexander, R.W.4
  • 44
    • 0033538516 scopus 로고    scopus 로고
    • Stimulation of a vascular smooth muscle cell NAD(P)H oxidase by thrombin. Evidence that p47(phox) may participate in forming this oxidase in vitro and in vivo
    • Patterson, C., Ruef, J., Madamanchi, N. R., Barry-Lane, P., Hu, Z., Horaist, C., Ballinger, C. A., Bode, C., and Runge, M. S. (1999) Stimulation of a vascular smooth muscle cell NAD(P)H oxidase by thrombin. Evidence that p47(phox) may participate in forming this oxidase in vitro and in vivo. J. Biol. Chem. 275, 19814-19822
    • (1999) J. Biol. Chem. , vol.275 , pp. 19814-19822
    • Patterson, C.1    Ruef, J.2    Madamanchi, N.R.3    Barry-Lane, P.4    Hu, Z.5    Horaist, C.6    Ballinger, C.A.7    Bode, C.8    Runge, M.S.9
  • 45
    • 0032545259 scopus 로고    scopus 로고
    • Lactosylceramide mediates tumor necrosis factor-alpha-induced intercellular adhesion molecule-1 (ICAM-1) expression and the adhesion of neutrophil in human umbilical vein endothelial cells
    • Bhunia, A. K., Arai, T., Bulkley, G., and Chatterjee, S. (1998) Lactosylceramide mediates tumor necrosis factor-alpha-induced intercellular adhesion molecule-1 (ICAM-1) expression and the adhesion of neutrophil in human umbilical vein endothelial cells. J. Biol. Chem. 273, 34349-34357
    • (1998) J. Biol. Chem. , vol.273 , pp. 34349-34357
    • Bhunia, A.K.1    Arai, T.2    Bulkley, G.3    Chatterjee, S.4
  • 46
    • 0034007969 scopus 로고    scopus 로고
    • Molecular mechanisms in intimal hyperplasia
    • Newby, A. C., and Zaltsman, A. B. (2000) Molecular mechanisms in intimal hyperplasia. J. Pathol. 190, 300-309
    • (2000) J. Pathol. , vol.190 , pp. 300-309
    • Newby, A.C.1    Zaltsman, A.B.2
  • 47
    • 0034995893 scopus 로고    scopus 로고
    • Oxidative stress regulates collagen synthesis and matrix metalloproteinase activity in cardiac fibroblasts
    • Siwik, D. A., Pagano, P. J., and Colucci, W. S. (2001) Oxidative stress regulates collagen synthesis and matrix metalloproteinase activity in cardiac fibroblasts. Am. J. Physiol. 280, C53-C60
    • (2001) Am. J. Physiol. , vol.280
    • Siwik, D.A.1    Pagano, P.J.2    Colucci, W.S.3
  • 48
    • 0032560638 scopus 로고    scopus 로고
    • N-acetyl-cysteine decreases the matrix-degrading capacity of macrophage-derived foam cells: New target for antioxidant therapy?
    • Galis, Z. S., Asanuma, K., Godin, D., and Meng, X. (1998) N-acetyl-cysteine decreases the matrix-degrading capacity of macrophage-derived foam cells: new target for antioxidant therapy? Circulation 97, 2445-2453
    • (1998) Circulation , vol.97 , pp. 2445-2453
    • Galis, Z.S.1    Asanuma, K.2    Godin, D.3    Meng, X.4
  • 49
    • 0035221859 scopus 로고    scopus 로고
    • Inhibitory effect of N-acetylcysteine on invasion and MMP-9 production of T24 human bladder cancer cells
    • Kawakami, S., Kageyama, Y., Fujii, Y., Kihara, K., and Oshima, H. (2001) Inhibitory effect of N-acetylcysteine on invasion and MMP-9 production of T24 human bladder cancer cells. Anticancer Res. 21, 213-219
    • (2001) Anticancer Res. , vol.21 , pp. 213-219
    • Kawakami, S.1    Kageyama, Y.2    Fujii, Y.3    Kihara, K.4    Oshima, H.5
  • 50
    • 0035319268 scopus 로고    scopus 로고
    • Ganglioside GD3 enhances apoptosis by suppressing the nuclear factor-kappa B-dependent survival pathway
    • Colell, A., Garcia-Ruiz, C., Roman, J., Ballesta, A., and Fernandez-Checa, J. C. (2001) Ganglioside GD3 enhances apoptosis by suppressing the nuclear factor-kappa B-dependent survival pathway. FASEB J. 15, 1068-1070
    • (2001) FASEB J. , vol.15 , pp. 1068-1070
    • Colell, A.1    Garcia-Ruiz, C.2    Roman, J.3    Ballesta, A.4    Fernandez-Checa, J.C.5


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.