Synthesis, structure analysis, and antitumor activity of 3,6-disubstituted-1,4-dihydro-1,2,4,5-tetrazine derivatives

Bioorganic and Medicinal Chemistry Letters

Volumn 16, Issue 14, 2006, Pages 3702-3705

  Rao, Guo Wu ^a   Hu, Wei Xiao ^a  

^a ZHEJIANG UNIVERSITY OF TECHNOLOGY   (China)

Author keywords

1,4 Dihydro 1,2,4,5 tetrazine; Antitumor activity; Chair conformation; Structure analysis

Indexed keywords

TETRAZINE DERIVATIVE;

ANTINEOPLASTIC ACTIVITY; ARTICLE; CALCULATION; CELL STRAIN HL 60; CHEMICAL REACTION; CONTROLLED STUDY; DRUG CONFORMATION; DRUG EFFICACY; DRUG RESEARCH; DRUG STRUCTURE; DRUG SYNTHESIS; HUMAN; HUMAN CELL; IN VITRO STUDY; REACTION ANALYSIS; STRUCTURE ACTIVITY RELATION; STRUCTURE ANALYSIS; SUBSTITUTION REACTION; X RAY DIFFRACTION;

ANIMALS; ANTINEOPLASTIC AGENTS; CELL PROLIFERATION; HL-60 CELLS; HUMANS; INHIBITORY CONCENTRATION 50; LEUKEMIA P388; LIVER NEOPLASMS; LUNG NEOPLASMS; MATHEMATICS; MICE; STRUCTURE-ACTIVITY RELATIONSHIP; TETRAZOLES; TUMOR CELLS, CULTURED; X-RAY DIFFRACTION;

EID: 33746555475     PISSN: 0960894X     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.bmcl.2006.04.066     Document Type: Article

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